University of Dundee

Wellcome Centre for Anti-Infectives Research (WCAIR)

  • Wellcome Centre for Anti-Infectives Research

The vision for the Wellcome Centre for Anti-Infectives Research (WCAIR) is to help tackle the urgent unmet medical need and lack of drug discovery research for Neglected Tropical Diseases (NTDs). This will be achieved by creating a world-leading hub for NTD drug discovery and being the collaborator of choice for academics, Pharma and Product Development Partnerships (PDPs) in the translation of discovery science into drug candidates.

WCAIR consolidates the existing world-leading NTD drug discovery expertise within the Division of Biological Chemistry and Drug Discovery bringing together the Drug Discovery Unit, the Mode of Action group and the Parasitology research groups providing an integrtaed pathway from discovery science to pre-clinical candidate selection.

WCAIR Themes

Drug Discovery

WCAIR will deliver high-quality pre-clinical drug candidates for NTDs with an initial focus on visceral leishmaniasis (VL) and Chagas’ disease (CD). To deliver solutions to the unmet medical and patient need research will address current key hindrances to timely drug development for NTDs creating new paradigms for NTD drug discovery. These include:

  • Innovate drug discovery approaches for VL and CD, including developing in silico and animal models that have improved prediction of Pharmacokinetic/Pharmacodynamic relationships and clinical efficacy.
  • Increased exploitation of novel drug targets, through structure-based drug discovery.
  • Develop tool compounds with known pharmacology to enable further understanding of parasite biology.
  • Improve the efficiency of drug discovery by establishing groups to facilitate compound scale up, compound purification and formatting.

Training

Develop and deliver a comprehensive training programme in drug discovery with an emphasis on capacity building in disease endemic countries.  A key component will be providing trainees with the opportunity to learn through working alongside researchers at WCAIR. If you would like to know more about the training programme please contact Susan Farrell.

Public Engagement

Activities will be aimed at enhancing public awareness of the impact and need for new medicines for NTDs and developing the public’s understanding of the drug discovery process and why it is important. For further information and opportunities to partner with WCAIR  on PE activities please contact Ali Floyd.

Partnerships

WCAIR has many existing global collaborators, including GSK’s kinetoplastid Discovery Performance Unit (DPU) (Tres Cantos, Spain; drug discovery), John Kelly and Simon Croft (London School of Hygiene and Tropical Medicine; animal disease models), Louis Maes (University of Antwerp; animal disease models), Drugs for Neglected Diseases initiative (DNDi, Geneva; general drug discovery and clinical development) and Medicines for Malaria Venture (clinical development of a potent oral anti-malarial candidate drug).

The Centre is interested in forging new collaborations with partners which can help us contribute to our vision. If you would like to explore opportunities for working with WCAIR then please contact the Centre Manager, Catharine Goddard.

Join Us

Current vacancies within WCAIR can be found on the School of Life Sciences vacancies webpage.  We also welcome  enquiries from dynamic people at any stage in their career who would like to work with us in Dundee. You can find more information about the career support and life benefits of living in Dundee here.

If you would like to make informal enquiries about working in WCAIR then please contact the Centre Manager, Catharine Goddard or the Centre Director, Paul Wyatt

WCAIR Management Board

Principal Investigators

Professor Alan Fairlamb CBE, FLS, FRSE, FMedSci, FSB
Professor of Biochemistry and Wellcome Principal Research Fellow
Biochemical Drug Targets in Parasites
Professor Mike Ferguson CBE FRS FRSE FMedSci
Regius Professor of Life Sciences and Academic Lead for Research Strategy
Molecular parasitology, glycobiology and drug discovery
Professor Mark Field
Professor of Cell Biology and Parasitology
Molecular parasitology, intracellular transport, gene expression, eukaryotic evolution
Professor Ian Gilbert FRSC
Professor of Medicinal Chemistry and Head of the Division of Biological Chemistry and Drug Discovery
Design and synthesis of potential therapeutic agents
Dr David Gray
Head of Biology
Molecular Pharmacology and Compound Screening
Professor David Horn FRSE
Professor of Parasite Molecular Biology
Antigenic variation, drug resistance and RNAi screens in trypanosomes
Dr Mattie Pawlowic
Principal Investigator, Lecturer
Professor Kevin Read
Professor of Quantitative Pharmacology and Head of Drug Metabolism and Pharmacokinetics
Drug discovery, lead optimisation and preclinical development
Professor Paul Wyatt FRSE
Professor of Drug Discovery and Head of the Drug Discovery Unit
The discovery of therapeutics for neglected diseases and the translation of novel biology through small molecule drug discovery

Independent Investigators

Dr Susan Wyllie
Independent Investigator - Mode of Action Group
Kinetoplastid Biology