Position: Professor of Medicinal Chemistry and Deputy-Head of the Division of Biological Chemistry and Drug Discovery
Division: Biological Chemistry and Drug Discovery
Address: College of Life Sciences,
University of Dundee,
Dundee
Telephone: +44 1382 386240, int ext. 86240
Fax: +44 1382 386373
Email: i.h.gilbert@dundee.ac.uk
Website: Gilbert Lab Group
I am a medicinal chemist and my research interests are in the design and synthesis of potential drugs. The mainstay of the work in my group is synthetic medicinal chemistry. Where possible we make extensive use of molecular modeling to guide our synthetic efforts. I have a particular interests in the following aspects of drug discovery:
1. Neglected diseases such as human African trypanosomiasis, leishmaniasis and malaria.
2. Novel approaches to and paradigms for drug discovery.
3. Chemical validation of drug targets, including novel targets for which there is little or no precedence for drug discovery.
4. Chemical methods for drug delivery.
1 .Aryl Phosphoramidates of 5-Phospho Erythronohydroxamic Acid, A New Class of Potent Trypanocidal Compounds. Ruda, G.-F.; Wong, P. E.; Alibu, V. P.; Norval, S.; Read, K. D.; Barrett, M. P.; Gilbert, I. H. J. Med. Chem.; 2010, 53, 6071-6078.
2. Virtual Fragment Screening for Novel Inhibitors of 6-Phosphogluconate Dehydrogenase. Ruda, G. F.; Campbell, G.; Alibu, V. P.; Barrett, M. P.; Brenk, R.; Gilbert, I. H. Bioorg. Med. Chem., 2010, 18, 5056-5062.
3. N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Frearson, J. A.; Brand, S.; McElroy, S. P.; Cleghorn, L. A. T.; Smid, O.; Stojanovski, L.; Price, H. P.; Guther, M. L. S.; Torrie, L. S.; Robinson, D. A.; Hallyburton, I.; Mpamhanga, C. P.; Brannigan, J. A.; Wilkinson, A. J.; Hodgkinson, M.; Hui, R.; Qiu, W.; Raimi, O. G.; Van Aalten, D. M. F.; Brenk, R.; Gilbert, I. H.; Read, K. D.; Fairlamb, A. H.; Ferguson, M. A. J.; Smith, D. F.; Wyatt, P. G. Nature, 2010, 464, 728-732.
4. Investigation of Trypanothione Reductase as a Drug Target in Trypanosoma brucei. Spinks, D.; Shanks, E. J.; Cleghorn, L. A. T.; McElroy, S.; Jones, D.; James, D.; Fairlamb, A. H.; Frearson, J. A.; Wyatt, P. G.; Gilbert, I. H. ChemMedChem, 2009, 4, 2060-2069.
5. Synthesis and Evaluation of 1-(1-(Benzo[b]thiophen-2-yl)cyclohexyl)piperidine (BTCP) Analogues as Inhibitors of Trypanothione Reductase. Patterson, S.; Jones, D. C.; Shanks, E. J.; Frearson, J. A.; Gilbert, I. H.; Wyatt, P. G.; Fairlamb, A. H.. ChemMedChem, 2009, 4, 1341-1353.
6. One Scaffold, Three Binding Modes. Mpamhanga, C. P.; Spinks, D.; Tulloch, L. B.; Shanks, E.; Robinson, D.; Collie, I.; Fairlamb, A. H.; Wyatt, P. G.; Frearson, J. A.; Hunter, W. N.; Gilbert, I. H.; Brenk, R. J. Med. Chem., 2009, 52, 4454-4465.
