Our Research
We study how chromosomes are copied in eukaryotic cells. Much of our work is focussed on ubiquitylation pathways that regulate the disassembly of the replisome - the multi-enzyme machine that makes a single copy of every chromosome in each cell cycle. We use diverse approaches that range from in vitro reconstitution with purified proteins, to cutting edge genetics / cell biology / biochemistry. Budding yeast has inspired much of what we do, but increasingly we study the duplication of metazoan chromosomes, using mouse embryonic stem cells and C. elegans early embryos as model systems.
Our Research
We study how chromosomes are copied in eukaryotic cells. Much of our work is focussed on ubiquitylation pathways that regulate the disassembly of the replisome - the multi-enzyme machine that makes a single copy of every chromosome in each cell cycle. We use diverse approaches that range from in vitro reconstitution with purified proteins, to cutting edge genetics / cell biology / biochemistry. Budding yeast has inspired much of what we do, but increasingly we study the duplication of metazoan chromosomes, using mouse embryonic stem cells and C. elegans early embryos as model systems.