Arturo Calzada (former postdoc in Karim Labib's lab).
Arturo Calzada Postdoc 2001-2002 Arturo studied the regulation of Cdc6 during his PhD with Avelino Bueno in Salamanca. Arturo then joined us for a year in Manchester, during which time he developed a system with which to study the regulation of paused replication forks in vivo. This work continued as a collaboration after Arturo returned to Salamanca (Calzada et al, Genes Dev., 2005; Hodgson et al, Mol. Biol. Cell, 2007). Arturo is now an investigator of the Spanish research council (CSIC), and works in collaboration with Rodrigo Bermejo at the Centro de Investigaciones Biológicas Margarita Salas in Madrid.
Giacomo De Piccoli (former postdoc in Karim Labib's lab)
Giacomo de Piccoli Postdoc 2008-2013 Giacomo studied in Turin and was then a PhD student with Luis Aragon in London, studying the role of the SMC5-6 complex in genome stability. After joining our group, Giacomo found that the S-phase checkpoint regulates the function but not the stability of the replisome (De Piccoli et al, Mol. Cell, 2012). Giacomo was awarded a Career Development Fellowship by Cancer Research U.K. and set up his own lab at the University of Warwick in 2013.
Magdalena Foltman (former PhD student in Karim Labib's lab).
Magda Foltman PhD student 2006-2010 Postdoc 2010-2011 Magda studied at the Jagiellonian University in Krakow, before joining us in 2006. Magda studied how the replisome contributes to processing of histones at DNA replication forks, and showed that the Mcm2 helicase subunit has a conserved histone-binding motif that is important to preserve repressive chromatin near telomeres (Foltman et al, Cell Rep., 2013). Magda is now a an assistant professor at the University of Santander in Spain.
Aga Gambus (former PhD student in Karim Labib's lab)
Aga Gambus PhD student 2002-2006 Aga studied at the Jagiellonian University in Krakow, before joining us in 2002. Aga made the important discovery that GINS associated with Mcm2-7 and Cdc45, together with a set of other factors , to form the Replisome Progression Complex (Gambus et al, Nat. Cell Biol., 2006). Aga then joined Julian Blow's group in Dundee as a post-doc, funded by a Sir Henry Wellcome Postdoctoral Fellowship, before receiving MRC and Birmingham Fellowships to establish her own group at the University of Birmingham. Aga received the Lister Research Prize and the BACR/AstraZeneca Young Investigator Award in 2015, and a Wellcome Trust investigator award in 2019.
Luis Javier Garcia Rodriguez (former postdoc in Karim Labib's lab).
Luis Javier Garcia Rodriguez Postdoc 2008-2012 Luis studied cell division as a PhD student in Salamanca and a postdoc at Columbia University in New York, before joining us a post-doctoral fellow in 2008. Luis showed that Ctf18-RFC uses a motif conserved from humans to yeast to associate with DNA polymerase epsilon (Garcia Rodriguez et al, Nuc. Acids Res., 2015). Luis then moved to Dundee to join the group of Tomo Tanaka, where he studies aspects of chromosome segregation in budding yeast.
Ben Hodgson (former postdoc in Karim Labib's lab).
Ben Hodgson Postdoc 2002-2006 Ben was a PhD student in Dundee with Julian Blow, before joining us as a post-doc in 2002. Ben collaborated with Arturo Calzada to establish a system for studying the regulation and composition of paused replisomes in vivo (Calzada et al, Genes Dev., 2005; Hodgson et al, Mol. Biol. Cell, 2007). Ben is currently a Senior Cell Biologist at the Cancer Research U.K. Manchester institute.
Ye Hong Postdoc 2017-2019 Ye's PhD studies were shared between Shandong University in China and the Max Plank Institute for Terrestrial Microbiology in Germany. Ye then joined Anton Gartner's group in Dundee, so that he could learn to use C. elegans as a model system for studying recombination. Subsequently, Ye joined our lab in 2017 and studied the role of Ctf4 and other replisome factors in the maintenance of repressive chromatin during worm development (Hong et al, in preparation). Ye is currently an assistant professor at Shandong University in Qingdao , China.
Masato Kanemaki (former postdoc in Karim Labib's lab)
Masato Kanemaki Postdoc 2001-2006 Masato was the first member of the lab, joining in July 2001 after his PhD studies in Japan. Together with Alberto Sanchez-Diaz, Masato discovered components of the GINS complex and showed that they were required for elongation (Kanemaki et al, Nature, 2003), then showed that Sld3 is essential for initiation but is dispensable for fork progression (Kanemaki and Labib, EMBO J., 2006). Masato returned to Japan in 2006 and is now a tenured professor at the National Institute for Genetics in Mishima. Masato's group developed the 'auxin-inducible degron' method for conditional inactivation of proteins in animal or fungal cells (Nishimura et al, Nat. Methods, 2009).
Timurs Maculins (former PhD student in Karim Labib's lab).
Timurs Maculins PhD student 2008-2012 Tim initially studied medicine in Latvia, but then switched to biomedical research and did a masters degree in Rotterdam in 2008. Tim joined us in 2009 and wanted to identify substrates of the ubiquitin ligase SCFDia2, which we had shown is associated with the Replisome Progressoin Complex (Morohashi et al, Curr. Biol., 2009). In collaboration with Marija Maric, Tim showed that SCFDia2 is required to ubiquitylated the CMG helicase in yeast cell extracts, and found that Dia2 is essential for CMG helicase disassembly (Maric, Maculins et al, Science, 2014; Maculins et al, Curr. Biol., 2015). Tim then worked as a postdoctoral fellow with Astrazeneca and with Ivan Dikic in Frankfurt, before joining Genentech as a Senior Scientific Researcher.
Vanessa Marchesi (former PhD student in Karim Labib's lab).
Vanessa Marchesi PhD student 2002-2006 Vanessa studied at Glasgow University before joining us as a PhD student in Manchester. She carried out part of our screen for new cell cycle proteins, using the heat-inducible degron method (Sanchez-Diaz et al, Nat. Cell Biol., 2009), and then characterised the Ctf18-RFC complex, showing that it associates with DNA polymerase epsilon (Garcia-Rodriguez et al, Nucl. Acids Res., 2015). Vanessa then worked as a post-doctoral fellow with the biotech company Pharmacia in Milan, and currently works as a scientific editor in Switzerland with The European Society for Medical Oncology.
Marija Maric (former PhD student in Karim Labib's lab).
Marija Maric PhD student 2010-2014 Postdoc 2014-2015 Marija studied in Zagreb, where she first heard of our lab at an EMBO 'Young Scientists Forum' that Karim helped to organise. Marija joined us in 2010 and studied the regulation of Mcm7 by ubiquitylation. This led to the discovery that Cdc48 is required for disassembly of ubiquitylated CMG helicase at the end of chromosome replication in budding yeast (Maric et al, Science, 2014). Marija moved with us to Dundee and stayed for a one-year post-doctoral period, before joining Simon Boulton's group at the Francis Crick institute in London as a postdoctoral fellow.
Pragya Mukherjee (PhD student in Karim Labib's lab)
Pragya Mukherjee PhD student 2014-2018 Postdoc 2018-2019 Pragya studied at the University of Delhi and then worked as a Junior Research Fellow at the Indian Institute of Science Eduction and Research in Pune, India, before joining our lab in 2014. Pragya showed that Cdc48-Ufd1-Npl4 are the minimal factors needed to disassemble ubiquitylated CMG helicase at the end of chromosome replication (Mukherjee and Labib, Cell Rep., 2019). Pragya is currently a postdoctoral fellow with Judith Frydman at Stanford.
Hiroko Nishikawa (former PhD student in Karim Labib's lab).
Hiroko Nishikawa (formerly Morohashi) PhD student 2004-2008 Hiroko studied at Osaka University and joined us as a PhD student in 2004. She showed that the E3 ubiquitin ligase SCFDia2 was associated with the Replisome Progression Complex (Morohashi et al, Curr. Biol., 2009). Hiroko is currently a postdoctoral fellow at the University of Tokyo, where she studies the human pathogen Helicobacter pylori.
Kohei Nishimura (former postdoc in Karim Labib's lab).
Kohei Nishimura Postdoc 2014-2015 Kohei did his PhD in the laboratory of Masato Kanemaki at the National Institute of Genetics in Mishima, Japan, where he developed the 'auxin-inducible degron' method (Nishimura et al, Nat. Methods, 2009). Kohei received a fellowship from the Japan Society for the Promotion of Science to join us for a year in Dundee, where he established protocols for genome editing in mouse ES cells by CRISPR-Cas9. Kohei is now an assistant professor at the University of Nagoya in Japan.
Pedro Junio Nkosi (Senior Research Technician in Karim Labib's lab)
Pedro Junior Nkosi Scientific Officer 2009-2016 Pedro obtained his Diploma of Technician in Biomedical Analysis from the Ecole Supérieure de la Santé and then worked as a medical technician in Lausanne. Pedro joined our lab in Manchester in 2009 and studied the role of SH3 proteins during cytokinesis in budding yeast (Nkosi et al, PLOS One, 2013). Pedro returned to Switzerland in 2016 to work as a research technician in the lab of Sophie Martin at the University of Lausanne.
Maria Angeles Ortiz Bazan Postdoc 2014-2017 Maria Angeles was a PhD student in Madrid with Jose Antonio Tercero at the Centro de Biología Molecular Severo Ochoa (CBMSO). Maria Angeles joined our lab in 2014 and was interested in how defects in termination impact upon the maintenance of genome integrity (Deegan et al, Mol Cell, 2019). After a period of maternity leave, Maria Angeles returned to Spain in the autumn of 2017 and is now a postdoctoral fellow with Andrés Aguilera in Sevilla.
Alberto Sanchez-Diaz (former postdoc in Karim Labib's lab).
Alberto Sanchez Diaz Postdoc 2001-2011 Alberto was a PhD student in Salamanca with Sergio Moreno and studied the regulation of the fission yeast cell cycle. After joining our group, Alberto used the heat-inducible degron to screen for new cell cycle proteins (Kanemaki, Sanchez-Diaz et al, Nature, 2003) and then focussed on a novel cytokinesis factor called Inn1 (Sanchez-Diaz et al, Nat. Cell Biol., 2009). Alberto returned to Spain with a Ramon y Cajal fellowship, and is now a professor at the University of Cantabria in Santander.
Sugopa Sengupta (former Postdoc in Karim Labib's lab).
Sugopa Sengupta Postdoc 2008-2012 Sugopa studied bacterial gyrase enzymes during her PhD at the Indian Institute of Science in Bangalore, before joining our group in 2008. Sugopa showed that DNA polymerase epsilon is incorporated into the replisome by direct binding to the CMG helicase (Sengupta et al, Curr. Biol., 2013). Sugopa is now an assistant professor at the Presidency University in Kolkata.
Asli Devrekanli (former PhD student in Karim Labib's lab)
Asli Sadli (formerly Devrekanli) PhD student 2007-2011 Asli studied at Ankara University and joined us as a PhD student in 2007. She identifed the Inn1 protein as a key regulator of the chitin synthase Chs2 during cytokinesis (Devrekanli et al, J. Cell Sci., 2012). Asli returned to Turkey in 2012 and is now an assistant professor at Trakya University in Turkey.
Ricky van Deursen (former Principal Scientific Officer in Karim Labib's lab).
Frederick van Deursen Principal Scientific Officer 2004-2013 Ricky joined the lab in Manchester as a 'Principal Scientific Officer', and studied the roles of Ctf4 (Gambus et al, EMBO J., 2009) and Mcm10 (van Deursen et al, EMBO J., 2012) during chromosome replication. In 2013, Ricky joined Qiagen as a Senior Scientist, responsible for assay design and development.
Abigail Wynne Jones (former scientific officer in Karim Labib's lab).
Abigail Wynne-Jones Research Technician 2001-2003 Abi was our first research technician (or 'Scientific Officer') and helped with the early stages of our functional genomic screens for new cell cycle proteins in budding yeast. In her spare time Abi represented Wales at fly fishing and crown green bowling, and in 2003 she returned to North Wales to join a Medical Equipment company.
Arturo Calzada (former postdoc in Karim Labib's lab).
Arturo Calzada Postdoc 2001-2002
Giacomo De Piccoli (former postdoc in Karim Labib's lab)
Giacomo de Piccoli Postdoc 2008-2013
Magdalena Foltman (former PhD student in Karim Labib's lab).
Magda Foltman PhD student 2006-2010 Postdoc 2010-2011
Aga Gambus (former PhD student in Karim Labib's lab)
Aga Gambus PhD student 2002-2006
Luis Javier Garcia Rodriguez (former postdoc in Karim Labib's lab).
Luis Javier Garcia Rodriguez Postdoc 2008-2012
Ben Hodgson (former postdoc in Karim Labib's lab).
Ben Hodgson Postdoc 2002-2006
Ye Hong Postdoc 2017-2019
Masato Kanemaki (former postdoc in Karim Labib's lab)
Masato Kanemaki Postdoc 2001-2006
Timurs Maculins (former PhD student in Karim Labib's lab).
Timurs Maculins PhD student 2008-2012
Vanessa Marchesi (former PhD student in Karim Labib's lab).
Vanessa Marchesi PhD student 2002-2006
Marija Maric (former PhD student in Karim Labib's lab).
Marija Maric PhD student 2010-2014 Postdoc 2014-2015
Pragya Mukherjee (PhD student in Karim Labib's lab)
Pragya Mukherjee PhD student 2014-2018 Postdoc 2018-2019
Hiroko Nishikawa (former PhD student in Karim Labib's lab).
Hiroko Nishikawa (formerly Morohashi) PhD student 2004-2008
Kohei Nishimura (former postdoc in Karim Labib's lab).
Kohei Nishimura Postdoc 2014-2015
Pedro Junio Nkosi (Senior Research Technician in Karim Labib's lab)
Pedro Junior Nkosi Scientific Officer 2009-2016
Maria Angeles Ortiz Bazan Postdoc 2014-2017
Alberto Sanchez-Diaz (former postdoc in Karim Labib's lab).
Alberto Sanchez Diaz Postdoc 2001-2011
Sugopa Sengupta (former Postdoc in Karim Labib's lab).
Sugopa Sengupta Postdoc 2008-2012
Asli Devrekanli (former PhD student in Karim Labib's lab)
Asli Sadli (formerly Devrekanli) PhD student 2007-2011
Ricky van Deursen (former Principal Scientific Officer in Karim Labib's lab).
Frederick van Deursen Principal Scientific Officer 2004-2013
Abigail Wynne Jones (former scientific officer in Karim Labib's lab).
Abigail Wynne-Jones Research Technician 2001-2003
Arturo Calzada (former postdoc in Karim Labib's lab).
Arturo Calzada Postdoc 2001-2002
Giacomo De Piccoli (former postdoc in Karim Labib's lab)
Giacomo de Piccoli Postdoc 2008-2013
Magdalena Foltman (former PhD student in Karim Labib's lab).
Magda Foltman PhD student 2006-2010 Postdoc 2010-2011
Aga Gambus (former PhD student in Karim Labib's lab)
Aga Gambus PhD student 2002-2006
Luis Javier Garcia Rodriguez (former postdoc in Karim Labib's lab).
Luis Javier Garcia Rodriguez Postdoc 2008-2012
Ben Hodgson (former postdoc in Karim Labib's lab).
Ben Hodgson Postdoc 2002-2006
Ye Hong Postdoc 2017-2019
Masato Kanemaki (former postdoc in Karim Labib's lab)
Masato Kanemaki Postdoc 2001-2006
Timurs Maculins (former PhD student in Karim Labib's lab).
Timurs Maculins PhD student 2008-2012
Vanessa Marchesi (former PhD student in Karim Labib's lab).
Vanessa Marchesi PhD student 2002-2006
Marija Maric (former PhD student in Karim Labib's lab).
Marija Maric PhD student 2010-2014 Postdoc 2014-2015
Pragya Mukherjee (PhD student in Karim Labib's lab)
Pragya Mukherjee PhD student 2014-2018 Postdoc 2018-2019
Hiroko Nishikawa (former PhD student in Karim Labib's lab).
Hiroko Nishikawa (formerly Morohashi) PhD student 2004-2008
Kohei Nishimura (former postdoc in Karim Labib's lab).
Kohei Nishimura Postdoc 2014-2015
Pedro Junio Nkosi (Senior Research Technician in Karim Labib's lab)
Pedro Junior Nkosi Scientific Officer 2009-2016
Maria Angeles Ortiz Bazan Postdoc 2014-2017
Alberto Sanchez-Diaz (former postdoc in Karim Labib's lab).
Alberto Sanchez Diaz Postdoc 2001-2011
Sugopa Sengupta (former Postdoc in Karim Labib's lab).
Sugopa Sengupta Postdoc 2008-2012
Asli Devrekanli (former PhD student in Karim Labib's lab)
Asli Sadli (formerly Devrekanli) PhD student 2007-2011
Ricky van Deursen (former Principal Scientific Officer in Karim Labib's lab).
Frederick van Deursen Principal Scientific Officer 2004-2013
Abigail Wynne Jones (former scientific officer in Karim Labib's lab).
Abigail Wynne-Jones Research Technician 2001-2003