Cell Biology of Colorectal Cancer.
We are a multi-disciplinary team interested in understanding how specific molecular events change cells and ultimately whole tissues during early stages of tumourigenesis. Our specific focus is on colorectal cancers and the contribution of changes in the adenomatous polyposis coli protein. Over the last years, our work has led us to examine not only how cells move and divide but also how they know where they are and how they work together to build a functional tissue.
Our experimental approaches include molecular biochemistry to study protein interactions, cell biology to measure changes in cultured cells, and tissue biology using isolated, fixed and living tissue. This allows us to apply and relate results from less complex systems to physiologically relevant situations. High-resolution microscopy (widefield, single and multi-photon) is an important part of out work. We actively interact with clinical colleagues in pathology and surgery but also with mathematicians to develop our work into the translational and systems biology arena.