Research Publications:

Newton IP, Kenneth NS, Appleton PL, Näthke I, Rocha S. Adenomatous Polyposis Coli and Hypoxia-inducible Factor-1{alpha} Have an Antagonistic Connection. (2010) Mol Biol Cell. 21(21):3630-3638. Epub Sep 15.
Jones, S.E.M., Joice, P., Cochrane, L., Thoresen, I., Quyn, A., Näthke, I. Is familial adenomatous polyposis associated with sensorineural hearing loss? (2010) Intl. J. Audiology, 49(10):762-764(3)
Radulescu S., Ridgway R.A., Appleton P., Kroboth K., Patel S., Woodgett J., Taylor S., Näthke I.S., Sansom O.J. “Defining the role of APC in the mitotic spindle checkpoint in vivo: APC-deficient cells are resistant to Taxol” (2010) Oncogene Aug 23. [Epub ahead of print]
Dikovskaya D., Li Z., Newton I.P., Davidson I., Hutchins J.R., Kalab P., Clarke P.R., Näthke I.S, “Microtubule assembly by the Apc protein is regulated by importin-beta--RanGTP.” (2010) J Cell Sci,. 123:736-746
Quyn A.J., Appleton P.L., Carey F.A., Steele R.J., Barker N., Clevers H., Ridgway R.A., Sansom O.J., Näthke I.S. “Spindle orientation bias in gut epithelial stem cell compartments is lost in precancerous tissues”, (2010) Cell Stem Cell. 6:175-181.
Buchert M., Athineos D., Abud H.E., Burke Z.D., Faux M.C., Samuel M.S., Jarnicki A.G., Winbanks C.E., Newton I.P., Meniel V.S., Suzuki H., Stacker S.A., Näthke I.S., Tosh D., Huelsken J., Clarke A.R., Heath J.K., Sansom O.J., Ernst M., “Genetic dissection of differential signaling threshold requirements for the Wnt/beta-catenin pathway in vivo.” (2010) PLoS Genet. 6(1):e1000816.
Appleton P.L., Quyn A.J., Swift S., Näthke I. “Preparation of wholemount mouse intestine for high-resolution three-dimensional imaging using 2-photon microscopy”, (2009) J. Microscopy, 234:196-204.
Li, Z., Kroboth, K., Newton, I.P., Näthke, I., “Novel self-association of the APC molecule affects APC clusters and cell migration”, (2008) J. Cell Science, 121:1916-25
Dikovskaya, D., Schiffman, D., Newton, I.P., Oakley, A., Kroboth, K., Jamieson, T.J., Meniel V., Clarke, A., Sansom, O., Näthke, I., “Loss of APC induces polyploidy due to a combination of defects in mitotic spindles, mitotic spindle checkpoint, and apoptosis”, (2007) J. Cell Biol., 15:183-195.
Kroboth, K., Newton, I.P., Zumbrunn, J., Li, Z., Kita, K., Waterman-Storer, C.M., Näthke, I.S., “Lack of adenomatous polyposis coli protein correlates with a decrease in cell migration and overall changes in microtubule stability”, (2007) Mol. Biol. Cell.,18:910-918.
Schiffmann, D.A., Dikovskaya, D., Appleton, P.L., Newton, I., Allan, C., Goldberg, I.G., Näthke, I.S., “Open Microscopy Environment & FindSpots: integrating image informatics with quantitative multidimensional image analysis”, (2006) Biotechniques, 41(2):199-208.
Kita, K., Wittmann, T., Näthke, I.S., Waterman-Storer, C.M., “APC protein modulates local microtubule assembly/disassembly dynamics independently of EB1”, (2006) Mol. Biol. Cell, 17:2331-2345.
Penman, G., Leung, L, and Näthke, I.S., “APC is present in different protein complexes with distinct functions”, (2005) J. Cell Science, 118:4741-4750.
Li, Z. and Näthke, I.S., “Tumour-associated NH2-terminal fragments are the most stable part of the adenomatous polyposis coli protein and can be regulated by interactions with COOH-terminal domains”, (2005), Cancer Research, 65:5195-5204.
Brocado, M, Näthke, I.S., Henderson, B.R., “Redefining the subcellular location and transport of APC: new insights using a panel of antibodies”, (2005) EMBO Rep., 6:184-190.
Sansom, O.J., Reed, K., Hayes, A.J., Ireland, H., Brinkmann, H., Newton, I.P., Batlle, E., Simon-Assmann, P., Hans Clevers, H., Näthke, I.S., Clarke, A.R, Winton, D.J., “Loss of APC in vivo immediately perturbs Wnt signaling, differentiation, and migration”, (2004) Genes&Development, 18:1385-1390.
Dikovskaya, D., Newton I.P., Näthke, I.S., “The Adenomatous Polyposis Coli protein is required for the formation of robust spindles formed in CSF Xenopus extracts”, (2004) Mol. Biol. Cell, 15:2978-2991.
Mogensen, M.M, Tucker, J.B., Mackie, J.B., Prescott, A.R., Näthke, I.S., “The Adenomatous Polyposis Coli protein unambiguously localises to microtubule plus ends and is involved in establishing parallel arrays of microtubule bundles in highly polarised epithelial cells”, (2002) J. Cell Biology, 157:1041-1048.
Zumbrunn, J., Inoshita, K., Hyman, A.A., Näthke, I.S. “Binding of the Adenomatous Polyposis Coli protein to microtubules increases microtubule stability and is regulated by GSK3b phosphorylation”, (2001) Current Biology, 11: 44-49.
Kaplan, K.B., Burds,, A.A., Swedlow, J.R., Bekir, S.S., Sorger, P.K., Näthke , I.S., “A novel role for the Adenomatous Polyposis Coli protein in chromosome segregation”, (2001) Nature Cell Biology, 3:429-432.
Ritchie, T., Zhou, W., McKinstry, E., Hosch, M., Zhang, Y., Näthke, I.S., Engelhardt, J.F., “Developmental Expression of catenins and associated proteins during submucosal gland morphogenesis in the airway”, (2001) Experimental Lung Research, 27:121-141.
Thomas, G.M., Frame, S., Goedert, M., Näthke, I.S. Polakis, P., Cohen, P., “A GSK3-binding peptide from FRAT1 selectively inhibits the GSK3b–catalysed phosphorylation of Axin and b-catenin”, (1999) FEBS Lett., 458:247-251.
Näthke, I.S., Adams , C.L., Polakis, P., Sellin, J.H., Nelson, W.J., “The Adenomatous Polyposis Coli (APC) tumor suppressor protein localizes to plasma membrane sites involved in active cell migration”, (1996) J. Cell Biol., 134:165-179.
Näthke, I.S., Hinck, L., Swedlow, J.R., Papkoff, J., Nelson, W.J., “Defining interactions and distributions of cadherin and catenin complexes in polarized epithelial cells”, (1994) J. Cell Biol., 125:1341-1352.
Hinck, L., Näthke, I. S., Papkoff, J., Nelson, W.J., “Dynamics of cadherin/catenin complex formation: novel protein interactions and pathways of complex assembly”, (1994) J. Cell Biol., 126:1327-1340
Näthke, I., Heuser, J., Lupas,, A., Stock, J., Turck, C., Brodsky, F.M. “Structural and functional organization of the clathrin heavy chain”, (1992) Cell, 68:899-910.
Näthke, I., Hill, B.L., Parham, P., Brodsky, F.M. “The calcium binding site of clathrin light chains”, (1990) J. Biol. Chem., 265:18621-18627.
Chin, D.J., Straubinger, R.M., Acton, S.L., Näthke, I., Brodsky, F.M. “100-kDa Polypeptides in peripheral clathrin-coated vesicles are required for receptor-mediated endocytosis”, (1989) Proc. Natl. Acad. Sci. USA, 86:9289-9293.

Invited Reviews and Bookchapters

Näthke, I. and McCartney, B., editors, “APC proteins” Landes Bioscience, (2009) Adv. Exp. Med. Biol. 656: vii-x.
McCartney, B.M. and Näthke, I.S., “Cell regulation by the Apc protein Apc as master regulator of epithelia.”, (2008) Current Opinion in Cell Biology, 20:1-8.
Quyn, A.J., Steele, R.J., Carey, F.A., Näthke, I.S., “Prognostic and therapeutic implications of Apc mutations in colorectal cancer.”, (2008) Surgeon 6: 350-356.
Wodarz, A. and Näthke, I., "Cell polarity in development and cancer.", (2007) Nature Cell Biology, 9:1016-1024.
Näthke, I., “Cytoskeleton out of the cupboard: colon cancer and cytoskeletal changes induced by loss of APC.” (2006) Nat. Cancer Reviews, 6: 967-974. (Cover image)
Näthke, I. and Nelson, W.J., editors of “Cell-to-cell contact and extracellular matrix: Laying down the rules for proper cell behavior”, (2005) Curr Opin Cell Biol. 17:443-445.
Näthke I. “Relationship between the role of the adenomatous polyposis coli protein in colon cancer and its contribution to cytoskeletal regulation.”, (2005) Biochem Soc Trans. 33 (Pt 4):694-697.
Näthke, I., “The adenomatous polyposis coli protein: the Achilles heel of the gut epithelium.” Ann. Rev. Cell & Develop. Biol., (2004) 20: 337-366.
Näthke, I., “APC at a glance.”, (2004) J. Cell Sci., 117:4873-4875.
Näthke, I., “Tracking APC’s attachment to the cytoskeleton”, (2002) ELSO Gazette: e-magazine of the European Life Scientist Organization, Issue 8.
Allan, V. and Näthke, I.S., “Catch and pull a microtubule: getting a grasp on the cortex.”, (2001) Nature Cell Biology, 3:E226-228.
Dikovskaya, D. Zumbrunn, J., Penman, G.A., Näthke, I.S., “The adenomatous polyposis coli protein: in the limelight out at the edge.”, (2001) Trends in Cell Biology, 11:378-384.
Näthke, I.S., “The adenomatous polyposis coli protein.”, (1999) Molecular Pathology 52:169-173.
Barth, A.I.M., Näthke,, I.S., Nelson, W.J., “Cadherins, catenins and APC protein: interplay between cytoskeletal complexes and signaling pathways.”, (1997) Curr. Opin. Cell Biol., 9:683-690.
Näthke, I.S., Barth, A.I.M., Nelson, W.J., “Role for the tumor suppressor Adenomatous Polyposis Coli protein in epithelial cell migration and adhesion: a hypothesis”, (1997) in Cytoskeletal-Membrane Interactions and Signal Transduction, pp103-110.
Näthke, I.S., Hinck, L., Nelson, W.J., “The cadherin/catenin complex: connections to multiple cellular processes involved in cell adhesion, proliferation and morphogenesis”, (1995) Sem. Dev. Biol. 6:89-95.
Hinck, L., Näthke, I.S., J. Papkoff, J., Nelson, W.J., “Beta-catenin: a common target for the regulation of cell adhesion by Wnt-1 and Src signaling pathways.”, (1994) Trends in Biochem. Sci. 19:538-542.
Näthke, I.S., Hinck, L., Nelson, W.J., “Epithelial cell adhesion and development of cell surface polarity: possible mechanisms for modulation of cadherin function, organization and distribution.”, (1993) J. Cell Science Suppl. 17:139-145.
Brodsky, F.M., Hill, B.L., Acton, S.L., Näthke, I., Wong, D.H., Ponnambalam, S., Parham, P., “Clathrin light chains: arrays of protein motifs that regulate coated-vesicle dynamics.”, (1991) Trends in Biochem. Sci. 16:208-213.
Brodsky, F.M., Guagliardi, L., Koppelmann, B., Acton, S.L., Wong, D.H., Näthke, I. “Endocytosis: molecular mechanism and role in the immune response”, in: Endocytosis: from cell biology to health, disease and therapy, P.J. Courtoy (ed.), (1990) NATO ASI Series 62:343-353.