University of Dundee

Postdoctoral Research Assistant

Unit: 
Medical Research Council Protein Phosphorylation and Ubiquitylation Unit
Job Reference: 
SLSC1082
Closing Date: 
Monday, May 30, 2022
Salary: 
£33,309 - £40,927
 

The Kulathu Lab at the MRC PPU, University of Dundee is looking to hire a postdoc with strong expertise in biochemistry to dissect how distinct branched heterotypic signals are formed in cells in response to stress and serve to trigger stress response pathways.

Our lab studies how posttranslational modification of proteins with monoubiquitin or different polyubiquitin chains alters protein function to signal distinct responses in cells. A new type of ubiquitin signal has been discovered recently that contains branched ubiquitin structures. These branched heterotypic ubiquitin signals are dynamically made in cells and play important roles in maintaining cellular homeostasis. Mechanistically, the functions of these branched chains have not been elucidated because of the complex nature of these modifications and the lack of ways to study them.

The successful candidate will employ a highly multidisciplinary approach, with techniques including protein engineering, structural biology, quantitative proteomics and single cell analyses to address exciting questions about the mechanisms and function of this emerging posttranslational modification.

The project is funded by an ERC Consolidator grant awarded recently to the lab, and the position is available for 3 years.

 
Who we're looking for:
We are looking for talented, motivated individuals with a PhD (or nearing completion of your PhD) in Biochemistry, Structural Biology or a related field, with a track record of publication in peer-reviewed journals.
 
Candidates will be expected to have expertise in one or more of the following areas:
  • Recombinant protein expression and purification
  • In vitro reconstitution and characterisation of multiprotein complexes
  • Biochemistry, enzyme kinetics
  • Cell biology
  • Protein quality control
  • Mass spectrometry
In addition, interests/experience in one or more of the following areas: ubiquitin system, protein quality control, neurodegeneration and signal transduction mechanisms regulated by posttranslational modifications, are desirable.
 
You will have a track record of research productivity and have demonstrated an ability to work independently, enthusiasm for research and excellent communication skills. It is expected that the candidate will develop and apply a broad range of techniques to pursue the research objectives.

Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. In this case the initial appointment would be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 25 – 28).

We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we’re close to both the train and bus stations. We also have campuses at Ninewells Hospital and in Kirkcaldy which are easily accessible via local transport links.

The University of Dundee is a signatory of the Researcher Development Concordat and is committed to enhancing the research environment and culture. Engagement and support of activities which assist the researcher development agenda at the University is therefore essential.

For further information about this position please contact Yogesh Kulathu at ykulathu@dundee.ac.uk. To find out more about Group/Unit/Team/School please visit https://www.ppu.mrc.ac.uk/.



To apply, please submit a single PDF file that contains:

  • A curriculum vitae. Please include list of publications and submissions to Biorxiv with a brief description of your contribution to the work.
  • A cover letter that outlines your research interests and career goals, a brief summary highlighting your expertise in biochemistry, structure-function analyses and cell biology.
Commitment to DORA

The School of Life Sciences has been fully committed to the principals of the San Francisco Declaration on Research Assessment (DORA) since 2013. In assessing applicants, we consider the scientific quality of their published research papers, but do not take into account where the papers were published and do not consider journal-based metrics, such as Journal Impact Factors.
 
As an internationally diverse institution, we welcome job applicants from all countries and nationalities.  The School of Life Sciences is proud to employ staff from over 40 different nations.

The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.