University of Dundee

Postdoctoral Research Assistant

Medical Research Council Protein Phosphorylation and Ubiquitylation Unit
Job Reference: 
Closing Date: 
Thursday, February 6, 2020
Grade 7 (£32,817 - £40,322)

A postdoctoral position is available Yogesh Kulathu's Lab, MRC PPU, University of Dundee, to investigate how Deubiquitinases (DUBs) achieve substrate recognition and specificity.

The Kulathu lab is focussed on understanding the mechanisms by which protein quality control and protein degradation are regulated by the ubiquitin system. We are particularly interested in understanding how aberrant proteins are recognized by the quality control machinery and tagged for degradation and the role of deubiquitinases (DUBs) in fine tuning protein degradation. Failure to degrade aberrant proteins in a timely manner can be toxic to a cell and result in neurodegenerative diseases such as Huntington’s and Alzheimer’s diseases, and highlights the need to understand pathways regulating protein degradation in greater detail.

The Kulathu lab uses a multidisciplinary approach in their research to elucidate pathways and mechanisms by which cells degrade proteins and maintain proteostasis. We seek enthusiastic, motivated researchers with a background in structural biology. By focussing on model multidomain DUBs that we are interested in, you will study how interplay between the different domains of the DUB controls enzyme activity and substrate recognition. You will use insights gained from this work to devise strategies to interfere with ubiquitylation of the target substrate and thereby stability. The available projects will employ in vitro reconstitution systems using purified components and structural biology approaches.

A fun and culturally diverse group of students/postdocs, we provide a learning, collaborative and supportive environment. Research is supported by the Medical Research Council, European Research Council Starting Grant, Lister Research Prize and EMBO Young Investigator Programme.

The position is available for 3 years in the first instance. Informal enquiries may be directed to

Candidate requirements:

You will be a talented, motivated individual with a PhD (or nearing completion of your PhD) with previous training in structural biology and experience studying multiprotein complexes. Interests in one or more of the following areas: ubiquitylation, protein quality control, neurodegeneration and signal transduction mechanisms regulated by posttranslational modifications, are desirable. You will have a track record of research productivity, enthusiasm for research and excellent communication skills. It is expected that the candidate will develop and apply a broad range of techniques to pursue the research objectives.

MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):

This project will be performed in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the School of Life Sciences at the University of Dundee. The MRC-PPU is in a beautiful location, embedded within the School of Life Sciences, University of Dundee, which is one of the premier Life Sciences research centres in the world.

Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £31,302).

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