The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.
The Drug Discovery Unit (DDU) is a fully integrated drug discovery operation based within a world class Life Sciences research environment. The DDU houses about 100 scientists structured in discipline focused teams (Medicinal Chemistry, Structural Biology, Computational Chemistry, Biophysical Screening, Biology, Compound Management, ADME/PK). Its remit is to complement BioPharma activities by tackling both neglected diseases (apicomplexan, tuberculosis and kinetoplastid disease) and validation of novel targets and mechanisms across a range of potential therapeutic areas. The DDU works to Biotech style philosophy and standards incorporating, dynamic, goal driven project management based on Target Product Profiles and Compound Selection Criteria. The project goals are therapeutic area dependent but range from quality leads demonstrating disease model proof of concept, through to pre-clinical candidates.
Artificial Intelligence (AI) and Machine/Deep Learning (ML,DL) are revolutionising the drug discovery process and the way compounds are optimised to achieve the desired biological activity and pharmacological profile. The DDU Computational Chemistry Team is looking for a highly motivated Scientist with experience in Chemoinformatics.
The successful candidate will join a team focused on the development of a platform integrating ML/DL/AI and physics based computational chemistry methods to drive and accelerate compounds biological activity and pharmacological profile optimisation.
The post is available immediately for two years. Starting salary from £32,817 to £49,553 depending on experience. A relocation allowance is available.
Necessary skills and experience:
• Highly motivated, self-directed individuals professionally qualified with a PhD in computational chemistry, bio/cheminformatics, or a related topic or a BSc and significant experience in working in the field.
• Experience in Chemoinformatics, Chemical Space enumeration and expansion
• Advance programming in Python
• Strong scientific background with an understanding of the Drug Discovery process
• Ability to work independently, and in close collaboration with discovery scientists as part of a team
• Good time management, organizational and communication skills.
• Strong interpersonal, communication and presentation skills
For Grade 8
• The candidate will have had experience running projects and line management experience
• Experience in developing processes and tools into a flexible and user-friendly platform – web based tools development front/back-end
• Expertise in Multiparameter optimisation
• Exposure to drug discovery projects
• Experience in hardware setup, networking support, software deployment and configuration
• Working knowledge of statistical modelling
• Experience in the application of AI/ML/DL methods to drug discovery
A few facts about The School of Life Sciences at Dundee:
• The School of Life Sciences has over 900 research and support staff from 59 countries and external funding in excess of £40 million per year
• Dundee has twice been named ‘the best place to work in Europe’ in a poll of scientists conducted by The Scientist magazine
• The School of Life Sciences has been consistently rated ‘5-star’ (the highest rating) by the UK national Research Assessment Exercise.
• Dundee, set on the east coast of Scotland, lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills.
We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city-centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage in design and technology. Just a short walk from the V&A Museum of Design Dundee, we’re close to both the train and bus stations. We also have campuses at Ninewells Hospital and in Kirkcaldy which are easily accessible via local transport links.
For further information about this position please contact Professor Ian Gilbert at I.H.Gilbert@dundee.ac.uk.
The diversity of our staff and students helps to make the University of Dundee a UK university of choice for undergraduate, postgraduate and distance learning. Family friendly policies, staff networks for BME, Disabled and LGBT staff, membership of Athena SWAN, the ECU Race Equality Charter and Stonewall as well a full range of disability services, create an enjoyable and inclusive place to work.