University of Dundee

Scientist (Medicinal Chemistry) 2 Posts

Biological Chemistry and Drug Discovery
Job Reference: 
Closing Date: 
Sunday, March 31, 2019
Grade 7 (£32,236 - £39,609)

We are advertising two medicinal chemistry positions, primarily laboratory-based, to join a multi-disciplinary team for a small molecule drug discovery program. This team is engaged in an exciting drug discovery collaboration between Professor Alessio Ciulli ( and Amphista Therapeutics, a start-up company founded in December 2017. The company seeks to discover novel therapeutics which accelerate protein degradation to develop drugs to treat cancer and other serious medical disorders.

We are looking for highly motivated scientists with a PhD in synthetic organic or medicinal chemistry with a keen interest in innovating and driving new approaches to drug discovery.

The successful candidates will work closely with the biology and structural biology and biophysics team, designing and synthesising hit and lead compounds and demonstrating appropriate pharmaceutical properties and efficacy.

Fixed term until 30 September 2019

Responsibilities include:

• Contributing to hit validation and hits-to-lead chemistry.

• Critically analyse project data and contribute ideas that will drive projects forward.

• Develop team science across the collaboration, working with colleagues across disciplines to aid breakthroughs.

• Analyse assay and pharmacokinetic data to design and synthesise new target compounds.

• Prepare verbal or written reports as required.

• Report directly to the Senior Research Chemist and to the Principal Investigator (Alessio Ciulli).

Required attributes:

• Candidates must be professionally qualified with a PhD in a chemical science related discipline; alternatively a BSc in chemistry with required subsequent experience of medicinal organic chemistry, ideally in the BioPharma industry.

• Proven expertise in synthetic chemistry route design and in carrying out synthetic organic chemistry.

• Strong interpersonal, communication and presentation skills.

• Strong interest in understanding the biological processes involved in the specific drug discovery program.

• Exceptional time management, organisational and self-motivational skills.

• A willingness to work with some flexibility to meet project milestones within a fast-paced, team-driven environment.

Preferred attributes:

• Understanding and appreciation of the drug discovery process.

• Strong academic track record, preferably with at least one first author publication in high-quality peer-reviewed journals.

• Experience with characterisation of protein-ligand complexes by biophysical techniques or with targeting protein degradation pathways.

A few facts about Dundee:

Dundee, set on the east coast of Scotland, has a relatively low cost of living and offers an exceptionally high quality of life. It lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills. Dundee’s central position offers an excellent gateway to Scotland’s major cities and best countryside.

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