Applications are invited for a postdoctoral position in the Ganley Lab to study the fundamentals of autophagy signalling. Recently we have uncovered multiple and unique pathways of in vivo mitophagy (autophagy of mitochondria – see (1,2)). However, we know very little about the signals that regulate these forms of mitophagy, which have been linked to diseases such as cancer and Parkinson’s. We are seeking a talented and highly motivated individual to characterise these pathways to determine how autophagosomes target seemingly random cellular components or highly specific ones, such as mitochondria. The project will involve a range of state-of-the-art techniques involving gene editing, biochemistry, microscopy and characterization of novel animal models.
1. McWilliams et al., Journal of Cell Biology 2016; 214(3):333-45
2. McWilliams et al., Cell Metabolism 2018; In Press (doi: 10.1016/j.cmet.2017.12.008)
• PhD with outstanding academic track record and at least one first authored publication in an internationally recognized peer-reviewed journal.
• Strong background in biochemistry and cell biology would be beneficial.
• Capable of working in a team, but able to plan and work independently.
• Excellent communication skills and knowledge of the English language.
This position is available immediately for up to three years.
Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £30,688).
MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):
The successful applicant will have the opportunity to work in an exciting and collaborative research environment, equipped to the highest international standards. Major aims of the MRC-PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease; to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation; and to generate reagents and improve technologies. Another key remit of the MRC-PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research. The MRC-PPU is in a beautiful location overlooking the estuary of the River Tay and embedded within the College of Life Sciences at the University of Dundee, which is one of the premier Life Sciences research Centres in the world. For further details please consult: http://www.ppu.mrc.ac.uk
How to apply:
To apply on-line click here.
The University of Dundee is a diverse community and is committed to equality of opportunity for all by providing a supportive, flexible and inclusive working environment. We have family friendly policies (including flexible working and childcare vouchers), staff groups for LGBT and BME; and prayer room facilities.
The University of Dundee has received the Athena SWAN Bronze Award (http://www.dundee.ac.uk/about/athenaswan/) which recognises the promotion of gender equality and has made further commitment to advancing inclusive culture which supports and encourages all under-represented groups.
The University of Dundee is a Scottish Registered Charity, No. SC015096.