We seek two highly motivated and versatile cell biologists with significant experience in developing cellular assays to support drug discovery programs, identifying targets and compounds mode of action and investigate disease relevant mechanisms. The successful candidate will join a multi-disciplinary team of scientists engaged in an exciting drug discovery collaboration between Professor Alessio Ciulli (http://www.lifesci.dundee.ac.uk/people/alessio-ciulli-0) and Amphista Therapeutics, a start-up company founded in 2017. The company seeks to discover novel therapeutics which accelerate protein degradation to develop drugs to treat cancer and other serious medical disorders. The successful candidates will work closely with the chemistry, structural biology and biophysics teams, to drive forward and innovate the biology of the collaboration.
• Developing relevant, novel and innovative cell-based and biochemical assays to address project challenges and support drug discovery projects. Applying these assays to screen and profile cellular activity of novel compounds and to interrogate target biology/disease relevant mechanisms
• Engage in exciting target identification and validation to verify the mechanism(s) of action of novel compounds
• Culturing human cell lines and using modern technologies to generate new cell lines
• Critically analyse project data and contribute ideas that will drive projects forward.
• Work in an interdisciplinary team to support our research strategies and project goals.
• Participate in building out the research capabilities of the Biology group.
• Develop team science across the collaboration, working with colleagues across disciplines to aid breakthroughs
• Report directly to the Senior Research Biologist and to the Principal Investigator (Alessio Ciulli).
• A PhD or equivalent industry experience in molecular cell biology, biochemistry, chemical biology or a related discipline is required.
• Prior experience in oncology drug discovery preferred but not essential
• Outstanding academic or industrial track records are strongly desired
• Strong background in cell biology, molecular biology and biochemistry techniques is required
• Proven competence in culturing cells in Category 2 facilities is essential
• Experience with shRNA and CRISPR and other relevant genome editing technologies will be a plus
• Experience with assays and technology for target identification and compounds mode of action will be a plus
• Demonstrated excellence in independently planning, executing experiments, data analysis and recordkeeping.
• Excellent verbal and written communication and interpersonal skills to work within an interdisciplinary team.
• Exceptional time management, organisational and self-motivational skills.
• Ability to work in a fast-paced, team-driven environment
This position is available until 30 September 2019.
A few facts about Dundee:
Dundee, set on the east coast of Scotland, has a relatively low cost of living and offers an exceptionally high quality of life. It lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills. Dundee’s central position offers an excellent gateway to Scotland’s major cities and best countryside.
Informal enquiries may be made to Professor Alessio Ciulli, e-mail: firstname.lastname@example.org
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