University of Dundee

Postdoctoral Research Assistant (Probing cellular signalling pathways regulated by ubiquitylation)

Unit: 
Medical Research Council Protein Phosphorylation and Ubiquitylation Unit
Job Reference: 
LS0297
Closing Date: 
Thursday, March 28, 2013
Salary: 
Grade 7 (£29,541 - £36,298)

Postdoctoral position in the laboratory of Dr. Yogesh Kulathu at the MRC Protein Phosphorylation and Ubiquitylation Unit, The Sir James Black Centre, University of Dundee, Scotland.


Applications are invited for a postdoctoral position in the newly established lab of Dr. Yogesh Kulathu to probe signalling in immune cells to discover and characterize novel ubiquitin signalling nodes. The candidate will develop new tools to investigate the ubiquitin system and apply these together with several recently developed methodologies and functional genomic screens to dissect ubiquitin signalling.


Polyubiquitylation regulates diverse cellular functions and eight different ubiquitin linkage types can be formed in cells. At present we only have limited knowledge of the cellular functions of many of these linkage types and the enzymes and mechanisms by which the different ubiquitin chain types are regulated. The laboratory uses an interdisciplinary approach to dissect ubiquitin-signalling to understand the underlying biochemical and structural mechanisms and genetic approaches to discover signalling nodes and pathways regulated by different ubiquitin modifications.


We are looking for an enthusiastic individual with interests in signal transduction mechanisms regulated by posttranslational modifications. The candidate should have a strong background in biochemistry with experience in studying signalling in mammalian cells.


In addition, the successful candidate will benefit from the cutting edge facilities in biochemistry, cell biology, drug discovery, and proteomics available within the College of Life Sciences.


This position is available for 3 years.


MRC Protein Phosphorylation and Ubiquitylation Unit (PPU):


This project will be performed in the MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU), based within the College of Life Sciences at the University of Dundee. The MRC-PPU is one of the world’s most renowned centres for research on protein phosphorylation and ubiquitylation (http://www.ppu.mrc.ac.uk/). Many world leading researchers in the field of signal transduction have trained within the MRC-PPU. The major aims of the MRC-PPU are to advance understanding of the role of protein phosphorylation and ubiquitylation in cell regulation and human disease, to facilitate the development of drugs to treat diseases caused by abnormalities in phosphorylation, to generate reagents and improve technologies. Another key remit of the MRC-PPU is to train the next generation of scientists who will advance our understanding in this crucial area of medical research. The MRC-PPU is in a beautiful location overlooking the estuary of the River Tay and embedded within the College of Life Sciences at the University of Dundee which is one of the premier Life Sciences research centres in the world.


Candidate requirements:


• PhD with outstanding academic track record and at least one first authored publication in an internationally recognised peer-reviewed journal
• A strong background in Biochemistry/Cell biology and an interest in Signal Transduction would be preferable
• Ability to work in a team, but able to plan and work independently
• Excellent communication skills and proficiency in English


How to apply:


To apply on-line click here. If you are unable to apply on-line please contact Human Resources on (01382) 386209 (answering machine) for an application pack. Please quote reference number LS0297. Closing Date: 28 March 2013.


The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community.
The University of Dundee is a Scottish Registered Charity, No. SC015096.