University of Dundee

Cell Signalling and Immunology

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Moraga lab receive €1.7 million ERC funding to fight autoimmune diseases

Dr Ignacio Moraga has been awarded €1.7 million to investigate the role that communication between cells plays in autoimmune diseases. The prestigious European Research Council (ERC) starting grant will fund his research over the next five years. Dr Moraga and his team are studying immune response action in the hope of designing better medicines for conditions such as lupus, arthritis and other debilitating autoimmune diseases.

Inflammasome activation in auto-inflammation

nflammasomes are scaffolds that are assembled in the host cytosol to cope with pathogens and cellular stress. The pattern-recognition receptors NLRP1, NLRP3, NLRC4, AIM2 and Pyrin all assemble distinct inflammasome platforms that contribute to host defense through proteolytic maturation and secretion of the inflammatory cytokines interleukin-(IL)1β and IL18, and by inducing pyroptosis, a pro-inflammatory regulated cell death mode.