University of Dundee

Biological Chemistry and Drug Discovery

Short Code: 

Postdoctoral Research Assistant

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

Postdoctoral Research Assistant

We are looking for a highly motivated researcher with appropriate skills in molecular and cell biology to work on our project ‘Gene editing in parasites for target validation and screening’. The project is funded by The Wellcome Trust and a major goal is to understand drug targets in parasitic trypanosomatids (Trypanosoma brucei, Trypanosoma cruzi and Leishmania donovani).

The post is available full-time for 2.25 years and salary will depend on experience, but will be up to £40,322.

CSC - Decoding gene expression mechanisms in trypanosomes

The African trypanosome, Trypanosoma brucei, is transmitted among mammalian hosts by tsetse flies. These unicellular parasites cause sleeping sickness, also known as Human African Trypanosomiasis, which is typically fatal if left untreated, and the livestock disease known as nagana. Molecular mechanisms underlying antigenic variation and gene expression control remain to be fully characterized.

CSC - Chemical Structural Biology and Mechanistic Insights into PROTAC Mode of Action

Pioneering discoveries from the Ciulli Laboratory and others have contributed to the establishment of a new modality of chemical intervention into biological system. The new paradigm-shift concept is that of targeting proteins for degradation using small molecules, as an alternative to conventional target blockade or inhibition. Protein degradation can be undertaken by double-headed molecules, also known as PROTACs, that recruit the target for ubiquitin mediated degradation by complexing them with E3 ubiquitin ligases, notably von Hippel-Lindau (VHL) and Cereblon (CRBN), amongst others.