University of Dundee

Cell Signalling and Immunology 2018

Andersen JL, Gesser B, Funder ED, Nielsen CJF, Gotfred-Rasmussen H, Rasmussen MK, Toth R, Gothelf KV, Arthur JSC, Iversen L, Nissen P. 2018. Dimethyl fumarate is an allosteric covalent inhibitor of the p90 ribosomal S6 kinases. Nature Communications. 9(1). https://doi.org/10.1038/s41467-018-06787-w

Ercoli G, Fernandes VE, Chung WY, Wanford JJ, Thomson S, Bayliss CD, Straatman K, Crocker PR, Dennison A, Martinez-Pomares L, Andrew PW, Moxon ER, Oggioni MR. 2018. Intracellular replication of Streptococcus pneumoniae inside splenic macrophages serves as a reservoir for septicaemia. Nature Microbiology. 3:600-610. https://doi.org/10.1038/s41564-018-0147-1

Freeley S, Cardone J, Günther SC, West EE, Reinheckel T, Watts C, Kemper C, Kolev MV. 2018. Asparaginyl endopeptidase (Legumain) supports human Th1 induction via cathepsin L-mediated intracellular C3 activation. Frontiers in Immunology. 9:1-7. https://doi.org/10.3389/fimmu.2018.02449

Fyffe FA, Hawley SA, Gray A, Hardie DG. 2018. Cell-Free Assays to Measure Effects of Regulatory Ligands on AMPK. Neumann D, Viollet B, editors. In AMPK : Methods and Protocols. Humana Press. pp. 69-86. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-7598-3_5

Gorby C, Martinez-Fabregas J, Wilmes S, Moraga Gonzalez I. 2018. Mapping determinants of cytokine signaling via protein engineering. Frontiers in Immunology. 9. https://doi.org/10.3389/fimmu.2018.02143

Hardie DG. 2018. Keeping the home fires burning: AMP-activated protein kinase. Journal of the Royal Society Interface. 15(138). https://doi.org/10.1098/rsif.2017.0774

Hawley SA, Fyffe FA, Russell FM, Gowans GJ, Hardie DG. 2018. Intact Cell Assays to Monitor AMPK and Determine the Contribution of the AMP-Binding or ADaM Sites to Activation. Neumann D, Viollet B, editors. In AMPK : Methods and Protocols. Humana Press. pp. 239-253. (Methods in Molecular Biology). https://doi.org/10.1007/978-1-4939-7598-3_16

Hoffmann T, Cwiklinski E, Shah D, Stretton C, Hyde R, Taylor P, Hundal H. 2018. Effects of sodium and amino acid substrate availability upon the expression and stability of the SNAT2 (SLC38A2) amino acid transporter. Frontiers in Pharmacology. 9:1-9. https://doi.org/10.3389/fphar.2018.00063

Lin S-C, Hardie D. 2018. AMPK: Sensing Glucose as well as Cellular Energy Status. Cell Metabolism. 27(2):299-313. https://doi.org/10.1016/j.cmet.2017.10.009

Lipina C, Walsh SK, Mitchell SE, Speakman JR, Wainwright CL, Hundal H. 2018. GPR55 deficiency is associated with increased adiposity and impaired insulin signaling in peripheral metabolic tissues. FASEB Journal. 33. https://doi.org/10.1096/fj.201800171R

Loftus RM, Assmann N, Kedia-Mehta N, O'Brien KL, Garcia A, Gillespie C, Hukelmann JL, Oefner PJ, Lamond AI, Gardiner CM, Dettmer K, Cantrell DA, Sinclair LV, Finlay DK. 2018. Amino acid-dependent cMyc expression is essential for NK cell metabolic and functional responses in mice. Nature Communications. 9(1):1-15. https://doi.org/10.1038/s41467-018-04719-2

Lu H, Bogdanovic E, Yu Z, Cho C, Liu L, Ho K, Guo J, Yeung LSN, Lehmann R, Hundal HS, Giacca A, Fantus IG. 2018. Combined Hyperglycemia and Hyperinsulinemia-induced Insulin Resistance in Adipocytes is associated with Dual Signaling Defects mediated by PKC-ζ. Endocrinology. 159(4):1658-1677. https://doi.org/10.1210/en.2017-00312

Martinez-Fabregas J, Prescott A, van Kasteren S, Leslie Pedrioli D, McLean W, Moles A, Reinheckel T, Poli V, Watts C. 2018. Lysosomal protease deficiency or substrate overload induces an oxidative-stress mediated STAT3-dependent pathway of lysosomal homeostasis. Nature Communications. 9(1). https://doi.org/10.1038/s41467-018-07741-6

McCarthy PC, Phair IR, Greger C, Pardali K, McGuire VA, Clark AR, Gaestel M, Arthur JSC. 2018. IL-33 regulates cytokine production and neutrophil recruitment via the p38 MAPK-activated kinases MK2/3. Immunology and Cell Biology. https://doi.org/10.1111/imcb.12200

Moral-Sanz J, Lewis SA, MacMillan S, Ross FA, Thomson A, Viollet B, Foretz M, Moran C, Hardie DG, Evans AM. 2018. The LKB1-AMPK-α1 signaling pathway triggers hypoxic pulmonary vasoconstriction downstream of mitochondria. Science Signaling. 11(550). https://doi.org/10.1126/scisignal.aau0296

Morgan EL, Wasson CW, Hanson L, Kealy D, Pentland I, McGuire V, Scarpini C, Coleman N, Arthur JSC, Parish JL, Roberts S, Macdonald A. 2018. STAT3 activation by E6 is essential for the differentiation-dependent HPV18 life cycle. PLoS Pathogens. 14(4):1-33. https://doi.org/10.1371/journal.ppat.1006975

Nagala M, McKenzie E, Richards H, Sharma R, Thomson S, Mastroeni P, Crocker P. 2018. Expression of Siglec-E alters the phenotype of macrophages but does not affect LPS-driven cytokine production or TLR4 endocytosis. Frontiers in Immunology. 8:1-17. https://doi.org/10.3389/fimmu.2017.01926

Nanda SK, Nagamori T, Windheim M, Amu S, Aviello G, Patterson-Kane J, Arthur JSC, Ley SC, Fallon P, Cohen P. 2018. ABIN2 Function Is Required To Suppress DSS-Induced Colitis by a Tpl2-Independent Mechanism. Journal of Immunology. 201(11):3373-3382. https://doi.org/10.4049/jimmunol.1700614

Rollings C, Sinclair L, Brady HJM, Cantrell D, Ross S. 2018. Interleukin-2 shapes the cytotoxic T cell proteome and immune environment sensing programs. Science Signaling. 11(526):1-16. https://doi.org/10.1126/scisignal.aap8112

Ross SH, Cantrell DA. 2018. Signaling and Function of Interleukin-2 in T Lymphocytes. Annual Review of Immunology. 36:411-433. https://doi.org/10.1146/annurev-immunol-042617-053352

Shinde PV, Xu HC, Maney SK, Kloetgen A, Namineni S, Zhuang Y, Honke N, Shaabani N, Bellora N, Doerrenberg M, Trilling M, Pozdeev VI, van Rooijen N, Scheu S, Pfeffer K, Crocker PR, Tanaka M, Duggimpudi S, Knolle P, Heikenwalder M, Ruland J, Mak TW, Brenner D, Pandyra AA, Hoell JI, Borkhardt A, Häussinger D, Lang KS, Lang PA. 2018. Tumor Necrosis Factor-mediated survival of CD169+ cells promotes immune activation during vesicular stomatitis virus infection. Journal of Virology. 92(3):1-18. https://doi.org/10.1128/JVI.01637-17

Sinclair L, Neyens D, Ramsay G, Taylor P, Cantrell D. 2018. Single cell analysis of kynurenine and System L amino acid transport in T cells. Nature Communications. 9(1). https://doi.org/10.1038/s41467- 018-04366-7.

Stathopoulou C, Gangaplara A, Mallett G, Flomerfelt FA, Liniany LP, Knight D, Samsel LA, Berlinguer-Palmini R, Yim JJ, Felizardo TC, Eckhaus MA, Edgington-Mitchell L, Martinez-Fabregas J, Zhu J, Fowler DH, van Kasteren SI, Laurence A, Bogyo M, Watts C, Shevach EM, Amarnath S. 2018. PD-1 Inhibitory Receptor Downregulates Asparaginyl Endopeptidase and Maintains Foxp3 Transcription Factor Stability in Induced Regulatory T Cells. Immunity. 49(2):247-263.e7. https://doi.org/10.1016/j.immuni.2018.05.006

Sutavani RV, Phair IR, Barker R, McFarlane A, Shpiro N, Lang S, Woodland A, Arthur JSC. 2018. Differential regulation of TLR4 induced IL-10 production in B cells and macrophages reveals a novel role for RSK1 and 2 in B cells. Journal of Biological Chemistry. 293(7):2302-2317. https://doi.org/10.1074/jbc.M117.805424

Thomas EC, Hook SC, Gray A, Chadt A, Carling D, Al-Hasani H, Heesom KJ, Hardie DG, Tavaré JM. 2018. Isoform-specific AMPK association with TBC1D1 is reduced by a mutation associated with severe obesity. The Biochemical journal. 475(18):2969-2983. https://doi.org/10.1042/BCJ20180475

van Dinther D, Veninga H, Iborra S, Borg EGF, Hoogterp L, Olesek K, Beijer MR, Schetters STT, Kalay H, Garcia-Vallejo JJ, Franken KL, Cham LB, Lang KS, van Kooyk Y, Sancho D, Crocker PR, den Haan JMM. 2018. Functional CD169 on Macrophages Mediates Interaction with Dendritic Cells for CD8+ T Cell Cross-Priming. Cell Reports. 22(6):1484-1495. https://doi.org/10.1016/j.celrep.2018.01.021

Vara Ciruelos D, Dandapani M, Gray A, Agbani EO, Evans AM, Hardie DG. 2018. Genotoxic Damage Activates the AMPK-α1 Isoform in the Nucleus via Ca2+/CaMKK2 Signaling to Enhance Tumor Cell Survival. Molecular Cancer Research. 16(2):345-357. https://doi.org/10.1158/1541-7786.MCR-17-0323