University of Dundee

Cell Signalling and Immunology 2015

Erikson, E., Wratil, P. R., Frank, M., Ambiel, I., Pahnke, K., Pino, M., Azadi, P., Izquierdo-Useros, N., Martinez-Picado, J., Meier, C., Schnaar, R. L., Crocker, P. R., Reutter, W. and Keppler, O. T. (2015) Mouse Siglec-1 Mediates trans-Infection of Surface-bound Murine Leukemia Virus in a Sialic Acid N-Acyl Side Chain-dependent Manner. J Biol Chem. 290, 27345-27359
10.1074/jbc.M115.681338
Pubmed; 4646371
PMC: 26370074

Griseri, T., Arnold, I. C., Pearson, C., Krausgruber, T., Schiering, C., Franchini, F., Schulthess, J., McKenzie, B. S., Crocker, P. R. and Powrie, F. (2015) Granulocyte Macrophage Colony-Stimulating Factor-Activated Eosinophils Promote Interleukin-23 Driven Chronic Colitis. Immunity. 43, 187-199
10.1016/j.immuni.2015.07.008
Pubmed; 4518500
PMC: 26200014

Hardie, D. G. (2015) Molecular Pathways: Is AMPK a Friend or a Foe in Cancer? Clin Cancer Res. 21, 3836-3840
10.1158/1078-0432.CCR-14-3300
Pubmed; 4558946
PMC: 26152739

Hardie, D. G. (2015) AMPK: positive and negative regulation, and its role in whole-body energy homeostasis. Curr Opin Cell Biol. 33, 1-7
10.1016/j.ceb.2014.09.004
PMC: 25259783

Hardie, D. G., Schaffer, B. E. and Brunet, A. (2015) AMPK: An Energy-Sensing Pathway with Multiple Inputs and Outputs. Trends Cell Biol10.1016/j.tcb.2015.10.013
PMC: 26616193

Hukelmann, J. L., Anderson, K. E., Sinclair, L. V., Grzes, K. M., Murillo, A. B., Hawkins, P. T., Stephens, L. R., Lamond, A. I. and Cantrell, D. A. (2015) The cytotoxic T cell proteome and its shaping by the kinase mTOR. Nat Immunol10.1038/ni.3314
PMC: 26551880

Jensen, T. E., Ross, F. A., Kleinert, M., Sylow, L., Knudsen, J. R., Gowans, G. J., Hardie, D. G. and Richter, E. A. (2015) PT-1 selectively activates AMPK-gamma1 complexes in mouse skeletal muscle, but activates all three gamma subunit complexes in cultured human cells by inhibiting the respiratory chain. Biochem J. 467, 461-472
10.1042/BJ20141142
PMC: 25695398

Karelina, K., Liu, Y., Alzate-Correa, D., Wheaton, K. L., Hoyt, K. R., Arthur, J. S. and Obrietan, K. (2015) Mitogen and stress-activated kinases 1/2 regulate ischemia-induced hippocampal progenitor cell proliferation and neurogenesis. Neuroscience. 285, 292-302
10.1016/j.neuroscience.2014.10.053
PMC: 25451279

Lang, E., Bissinger, R., Fajol, A., Salker, M. S., Singh, Y., Zelenak, C., Ghashghaeinia, M., Gu, S., Jilani, K., Lupescu, A., Reyskens, K. M., Ackermann, T. F., Foller, M., Schleicher, E., Sheffield, W. P., Arthur, J. S., Lang, F. and Qadri, S. M. (2015) Accelerated apoptotic death and in vivo turnover of erythrocytes in mice lacking functional mitogen- and stress-activated kinase MSK1/2. Sci Rep. 5, 17316
10.1038/srep17316
Pubmed; 4661433
PMC: 26611568

Lipina, C. and Hundal, H. S. (2015) Ganglioside GM3 as a gatekeeper of obesity-associated insulin resistance: Evidence and mechanisms. FEBS Lett. 589, 3221-3227
10.1016/j.febslet.2015.09.018
PMC: 26434718

Lipina, C., Nardi, F., Grace, H. and Hundal, H. S. (2015) NEU3 sialidase as a marker of insulin sensitivity: Regulation by fatty acids. Cell Signal. 27, 1742-1750
10.1016/j.cellsig.2015.05.010
PMC: 26022181

McGuire, V. A. and Arthur, J. S. (2015) Subverting Toll-Like Receptor Signaling by Bacterial Pathogens. Front Immunol. 6, 607
10.3389/fimmu.2015.00607
Pubmed; 4664646
PMC: 26648936

Nardi, F., Hoffmann, T. M., Stretton, C., Cwiklinski, E., Taylor, P. M. and Hundal, H. S. (2015) Proteasomal modulation of cellular SNAT2 (SLC38A2) abundance and function by unsaturated fatty acid availability. J Biol Chem. 290, 8173-8184
10.1074/jbc.M114.625137
Pubmed; 4375474
PMC: 25653282

O'Neill, A. S., Terry, S. Y., Brown, K., Meader, L., Wong, A. M., Cooper, J. D., Crocker, P. R., Wong, W. and Mullen, G. E. (2015) Non-invasive molecular imaging of inflammatory macrophages in allograft rejection. EJNMMI Res. 5, 69
10.1186/s13550-015-0146-7
Pubmed; 4661159
PMC: 26611870

Pallett, L. J., Gill, U. S., Quaglia, A., Sinclair, L. V., Jover-Cobos, M., Schurich, A., Singh, K. P., Thomas, N., Das, A., Chen, A., Fusai, G., Bertoletti, A., Cantrell, D. A., Kennedy, P. T., Davies, N. A., Haniffa, M. and Maini, M. K. (2015) Metabolic regulation of hepatitis B immunopathology by myeloid-derived suppressor cells. Nat Med. 21, 591-600
10.1038/nm.3856
Pubmed; 4458139
PMC: 25962123

Pirkmajer, S., Kulkarni, S. S., Tom, R. Z., Ross, F. A., Hawley, S. A., Hardie, D. G., Zierath, J. R. and Chibalin, A. V. (2015) Methotrexate promotes glucose uptake and lipid oxidation in skeletal muscle via AMPK activation. Diabetes. 64, 360-369
10.2337/db14-0508
Pubmed; PMC: 25338814

Preston, G. C., Sinclair, L. V., Kaskar, A., Hukelmann, J. L., Navarro, M. N., Ferrero, I., MacDonald, H. R., Cowling, V. H. and Cantrell, D. A. (2015) Single cell tuning of Myc expression by antigen receptor signal strength and interleukin-2 in T lymphocytes. EMBO J. 34, 2008-2024
10.15252/embj.201490252
Pubmed; 4551349
PMC: 26136212

Ramsay, G. and Cantrell, D. (2015) Environmental and metabolic sensors that control T cell biology. Front Immunol. 6, 99
10.3389/fimmu.2015.00099
Pubmed; 4362047
PMC: 25852681

Rog-Zielinska, E. A., Craig, M. A., Manning, J. R., Richardson, R. V., Gowans, G. J., Dunbar, D. R., Gharbi, K., Kenyon, C. J., Holmes, M. C., Hardie, D. G., Smith, G. L. and Chapman, K. E. (2015) Glucocorticoids promote structural and functional maturation of foetal cardiomyocytes: a role for PGC-1alpha. Cell Death Differ. 22, 1106-1116
10.1038/cdd.2014.181
Pubmed; 4572859
PMC: 25361084

Ross, F., Jensen, T. E. and Hardie, D. G. (2015) Differential regulation by AMP and ADP of AMPK complexes containing different gamma subunit isoforms. Biochem J10.1042/BJ20150910
Pubmed; PMC: 26542978

Schneider, H., Schubert, K. M., Blodow, S., Kreutz, C. P., Erdogmus, S., Wiedenmann, M., Qiu, J., Fey, T., Ruth, P., Lubomirov, L. T., Pfitzer, G., Mederos, Y. S. M., Hardie, D. G., Gudermann, T. and Pohl, U. (2015) AMPK Dilates Resistance Arteries via Activation of SERCA and BKCa Channels in Smooth Muscle. Hypertension. 66, 108-116
10.1161/HYPERTENSIONAHA.115.05514
PMC: 26034200

Shao, B., Yago, T., Setiadi, H., Wang, Y., Mehta-D'souza, P., Fu, J., Crocker, P. R., Rodgers, W., Xia, L. and McEver, R. P. (2015) O-glycans direct selectin ligands to lipid rafts on leukocytes. Proc Natl Acad Sci U S A. 112, 8661-8666
10.1073/pnas.1507712112
Pubmed; 4507194
PMC: 26124096

Stone, E. L., Pepper, M., Katayama, C. D., Kerdiles, Y. M., Lai, C. Y., Emslie, E., Lin, Y. C., Yang, E., Goldrath, A. W., Li, M. O., Cantrell, D. A. and Hedrick, S. M. (2015) ICOS coreceptor signaling inactivates the transcription factor FOXO1 to promote Tfh cell differentiation. Immunity. 42, 239-251
10.1016/j.immuni.2015.01.017
Pubmed; 4334393
PMC: 25692700

Stretton, C., Hoffmann, T. M., Munson, M. J., Prescott, A., Taylor, P. M., Ganley, I. G. and Hundal, H. S. (2015) GSK3-mediated raptor phosphorylation supports amino-acid-dependent mTORC1-directed signalling. Biochem J. 470, 207-221
10.1042/BJ20150404
PMC: 26348909

Tan, L., Akahane, K., McNally, R., Reyskens, K. M., Ficarro, S. B., Liu, S., Herter-Sprie, G. S., Koyama, S., Pattison, M. J., Labella, K., Johannessen, L., Akbay, E. A., Wong, K. K., Frank, D. A., Marto, J. A., Look, T. A., Arthur, J. S., Eck, M. J. and Gray, N. S. (2015) Development of Selective Covalent Janus Kinase 3 Inhibitors. J Med Chem. 58, 6589-6606
10.1021/acs.jmedchem.5b00710
PMC: 26258521

Yung, M. M., Ross, F. A., Hardie, D. G., Leung, T. H., Zhan, J., Ngan, H. Y. and Chan, D. W. (2015) Bitter Melon (Momordica charantia) Extract Inhibits Tumorigenicity and Overcomes Cisplatin-Resistance in Ovarian Cancer Cells Through Targeting AMPK Signaling Cascade. Integr Cancer Ther10.1177/1534735415611747
PMC: 26487740

Zaru, R., Edgar, A. J., Hanauer, A. and Watts, C. (2015) Structural and functional basis for p38-MK2-activated Rsk signaling in toll-like receptor-stimulated dendritic cells. Mol Cell Biol. 35, 132-140
10.1128/MCB.00773-14
Pubmed; 4295372
PMC: 25332232

Zaru, R., Matthews, S. P., Edgar, A. J., Prescott, A. R., Gomez-Nicola, D., Hanauer, A. and Watts, C. (2015) The PDK1-Rsk Signaling Pathway Controls Langerhans Cell Proliferation and Patterning. J Immunol. 195, 4264-4272
10.4049/jimmunol.1501520
Pubmed; 4640173
PMC: 26401001

Zhou, Z., Rawnsley, D. R., Goddard, L. M., Pan, W., Cao, X. J., Jakus, Z., Zheng, H., Yang, J., Arthur, J. S., Whitehead, K. J., Li, D., Zhou, B., Garcia, B. A., Zheng, X. and Kahn, M. L. (2015) The cerebral cavernous malformation pathway controls cardiac development via regulation of endocardial MEKK3 signaling and KLF expression. Dev Cell. 32, 168-180
10.1016/j.devcel.2014.12.009
Pubmed; 4589864
PMC: 25625206