University of Dundee

Biological Chemistry and Drug Discovery 2016

Allen, E. H., Courtney, D. G., Atkinson, S. D., Moore, J. E., Mairs, L., Poulsen, E. T., Schiroli, D., Maurizi, E., Cole, C., Hickerson, R. P., James, J., Murgatroyd, H., Smith, F. J., MacEwen, C., Enghild, J. J., Nesbit, M. A., Leslie Pedrioli, D. M., McLean, W. H. and Moore, C. B. (2016) Keratin 12 missense mutation induces the unfolded protein response and apoptosis in Meesmann epithelial corneal dystrophy. Human molecular genetics. 25, 1176-1191
d.o.i: 10.1093/hmg/ddw001
PMID: 4764196
PMC: ^26758872

Ballell, L., Strange, M., Cammack, N., Fairlamb, A. H. and Borysiewicz, L. (2016) Open Lab as a source of hits and leads against tuberculosis, malaria and kinetoplastid diseases. Nature reviews. Drug discovery. 15, 292
d.o.i: 10.1038/nrd.2016.51
PMC: ^27020099

Baragana, B. and Gilbert, I. H. et al (2016) Corrigendum: A novel multiple-stage antimalarial agent that inhibits protein synthesis. Natured.o.i: 10.1038/nature18280
PMC: ^27281209

Baragana, B., Norcross, N. R., Wilson, C., Porzelle, A., Hallyburton, I., Grimaldi, R., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R., Wyatt, P. G., Delves, M. J., Meister, S., Duffy, S., Avery, V. M., Winzeler, E. A., Sinden, R. E., Wittlin, S., Frearson, J. A., Gray, D. W., Fairlamb, A. H., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. and Gilbert, I. H. (2016) Discovery of a Quinoline-4-carboxamide Derivative with a Novel Mechanism of Action, Multistage Antimalarial Activity, and Potent in Vivo Efficacy. Journal of medicinal chemistryd.o.i: 10.1021/acs.jmedchem.6b00723
PMC: ^27631715

Baud, M. G., Lin-Shiao, E., Zengerle, M., Tallant, C. and Ciulli, A. (2016) New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition. Journal of medicinal chemistry. 59, 1492-1500
d.o.i: 10.1021/acs.jmedchem.5b01135
PMID: 4770307
PMC: ^26367539

Brinkhuizen, T., Frencken, K. J., Nelemans, P. J., Hoff, M. L., Kelleners-Smeets, N. W., Hausen, A. Z., van der Horst, M. P., Rennspiess, D., Winnepenninckx, V. J., van Steensel, M. A. and Mosterd, K. (2016) The effect of topical diclofenac 3% and calcitriol 3 mug/g on superficial basal cell carcinoma (sBCC) and nodular basal cell carcinoma (nBCC): A phase II, randomized controlled trial. Journal of the American Academy of Dermatologyd.o.i: 10.1016/j.jaad.2016.01.050
PMID: PMC: ^27067393

Brinkhuizen, T., van Geel, M., Denil, S. L., De Meyer, T., Kelleners-Smeets, N. W., Lohuis, P. J., Hoebers, F. J., Winnepenninckx, V. J., van Steensel, M. A. and Mosterd, K. (2016) Locally advanced basal cell carcinoma has a distinct methylation and transcriptomic profile. Experimental dermatology. 25, 316-318
d.o.i: 10.1111/exd.12905
PMC: ^26662714

Bruhn, D. F., Wyllie, S., Rodriguez-Cortes, A., Carrillo, A. K., Rakesh, Guy, R. K., Fairlamb, A. H. and Lee, R. E. (2016) Pentacyclic nitrofurans that rapidly kill nifurtimox-resistant trypanosomes. The Journal of antimicrobial chemotherapy. 71, 956-963
d.o.i: 10.1093/jac/dkv417
PMID: 4790617
PMC: ^26682963

Cardote, T. A. and Ciulli, A. (2016) Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions. ChemMedChem. 11, 787-794
d.o.i: 10.1002/cmdc.201500450
PMID: 4848765
PMC: ^26563831

Ciulli, A. (2016) Target validation: Switching domains. Nature chemical biology. 12, 659-660
d.o.i: 10.1038/nchembio.2154
PMC: ^27538023

Courtney, D. G., Moore, J. E., Atkinson, S. D., Maurizi, E., Allen, E. H., Pedrioli, D. M., McLean, W. H., Nesbit, M. A. and Moore, C. B. (2016) CRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targeting. Gene therapy. 23, 108-112
d.o.i: 10.1038/gt.2015.82
PMID: 4705418
PMC: ^26289666

Dacks, J. B., Field, M. C., Buick, R., Eme, L., Gribaldo, S., Roger, A. J., Brochier-Armanet, C. and Devos, D. P. (2016) The changing view of eukaryogenesis - fossils, cells, lineages and how they all come together. Journal of cell science. 129, 3695-3703
d.o.i: 10.1242/jcs.178566
PMC: ^27672020

Damerow, M., Graalfs, F., Guther, M. L., Mehlert, A., Izquierdo, L. and Ferguson, M. A. (2016) A Gene of the beta3-Glycosyltransferase Family Encodes N-Acetylglucosaminyltransferase II Function in Trypanosoma brucei. The Journal of biological chemistry. 291, 13834-13845
d.o.i: 10.1074/jbc.M116.733246
PMID: 4919465
PMC: ^27189951

Damerow, S., Hoppe, C., Bandini, G., Zarnovican, P., Buettner, F. F., Luder, C. G., Ferguson, M. A. and Routier, F. H. (2016) Correction: Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major. PLoS neglected tropical diseases. 10, e0004372
d.o.i: 10.1371/journal.pntd.0004372
PMID: 4703375
PMC: ^26735928

De Rycker, M., Thomas, J., Riley, J., Brough, S. J., Miles, T. J. and Gray, D. W. (2016) Identification of Trypanocidal Activity for Known Clinical Compounds Using a New Trypanosoma cruzi Hit-Discovery Screening Cascade. PLoS neglected tropical diseases. 10, e0004584
d.o.i: 10.1371/journal.pntd.0004584
PMID: 4833300
PMC: ^27082760

Dewar, S., Sienkiewicz, N., Ong, H. B., Wall, R. J., Horn, D. and Fairlamb, A. H. (2016) The role of folate transport in antifolate drug action in Trypanosoma brucei. The Journal of biological chemistryd.o.i: 10.1074/jbc.M116.750422
PMC: ^27703008

Dias, D. M., Furtado, J., Wasielewski, E., Cruz, R., Costello, B., Cole, L., Faria, T. Q., Baaske, P., Brito, R. M., Ciulli, A., Simoes, I., Macedo-Ribeiro, S., Faro, C., Geraldes, C. F. and Castanheira, P. (2016) Biophysical characterization of laforin-carbohydrate interaction. The Biochemical journal. 473, 335-345
d.o.i: 10.1042/BJ20141555
PMC: ^26578817

Duraisingh, M. T. and Horn, D. (2016) Epigenetic Regulation of Virulence Gene Expression in Parasitic Protozoa. Cell host & microbe. 19, 629-640
d.o.i: 10.1016/j.chom.2016.04.020
PMC: ^27173931

Fairlamb, A. H., Gow, N. A., Matthews, K. R. and Waters, A. P. (2016) Drug resistance in eukaryotic microorganisms. Nature microbiology. 1, 16092
d.o.i: 10.1038/nmicrobiol.2016.92
PMC: ^27572976

Favre, P., Seebeck, J., Thistlethwaite, P. A., Obrist, M., Steffens, J. G., Hopkins, A. R. and Hulme, P. A. (2016) In vitro initial stability of a stemless humeral implant. Clinical biomechanics. 32, 113-117
d.o.i: 10.1016/j.clinbiomech.2015.12.004
PMC: ^26747397

Flegontov, P., Butenko, A., Firsov, S., Kraeva, N., Elias, M., Field, M. C., Filatov, D., Flegontova, O., Gerasimov, E. S., Hlavacova, J., Ishemgulova, A., Jackson, A. P., Kelly, S., Kostygov, A. Y., Logacheva, M. D., Maslov, D. A., Opperdoes, F. R., O'Reilly, A., Sadlova, J., Sevcikova, T., Venkatesh, D., Vlcek, C., Volf, P., Votypka, J., Zahonova, K., Yurchenko, V. and Lukes, J. (2016) Genome of Leptomonas pyrrhocoris: a high-quality reference for monoxenous trypanosomatids and new insights into evolution of Leishmania. Scientific reports. 6, 23704
d.o.i: 10.1038/srep23704
PMID: 4810370
PMC: ^27021793

Fleming, J. R., Sastry, L., Wall, S. J., Sullivan, L. and Ferguson, M. A. (2016) Proteomic Identification of Immunodiagnostic Antigens for Trypanosoma vivax Infections in Cattle and Generation of a Proof-of-Concept Lateral Flow Test Diagnostic Device. PLoS neglected tropical diseases. 10, e0004977
d.o.i: 10.1371/journal.pntd.0004977
PMID: 5015970
PMC: ^27606593

Forbes, D., Johnston, L., Gardner, J., MacCallum, S. F., Campbell, L. E., Dinkova-Kostova, A. T., McLean, W. H., Ibbotson, S. H., Dawe, R. S. and Brown, S. J. (2016) Filaggrin genotype does not determine the skin's threshold to UV-induced erythema. The Journal of allergy and clinical immunology. 137, 1280-1282 e1281-1283
d.o.i: 10.1016/j.jaci.2015.11.022
PMID: 4819769
PMC: ^26830116

Gage, Z. O., Vasou, A., Gray, D. W., Randall, R. E. and Adamson, C. S. (2016) Identification of Novel Inhibitors of the Type I Interferon Induction Pathway Using Cell-Based High-Throughput Screening. Journal of biomolecular screening. 21, 978-988
d.o.i: 10.1177/1087057116656314
PMID: 5030734
PMC: ^27358388

Galdeano, C. and Ciulli, A. (2016) Selectivity on-target of bromodomain chemical probes by structure-guided medicinal chemistry and chemical biology. Future medicinal chemistry. 8, 1655-1680
d.o.i: 10.4155/fmc-2016-0059
PMC: ^27193077

Gibson, M. W., Dewar, S., Ong, H. B., Sienkiewicz, N. and Fairlamb, A. H. (2016) Trypanosoma brucei DHFR-TS Revisited: Characterisation of a Bifunctional and Highly Unstable Recombinant Dihydrofolate Reductase-Thymidylate Synthase. PLoS neglected tropical diseases. 10, e0004714
d.o.i: 10.1371/journal.pntd.0004714
PMID: 4866688
PMC: ^27175479

Glover, L., Hutchinson, S., Alsford, S. and Horn, D. (2016) VEX1 controls the allelic exclusion required for antigenic variation in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America. 113, 7225-7230
d.o.i: 10.1073/pnas.1600344113
PMID: 4932947
PMC: ^27226299

Graf, F. E., Ludin, P., Arquint, C., Schmidt, R. S., Schaub, N., Kunz Renggli, C., Munday, J. C., Krezdorn, J., Baker, N., Horn, D., Balmer, O., Caccone, A., de Koning, H. P. and Maser, P. (2016) Comparative genomics of drug resistance in Trypanosoma brucei rhodesiense. Cellular and molecular life sciences : CMLS. 73, 3387-3400
d.o.i: 10.1007/s00018-016-2173-6
PMID: 4967103
PMC: ^26973180

Hee, L., Terluk, A., Thomas, L., Hopkins, A., Juergens, C. P., Lo, S., French, J. K. and Mussap, C. J. (2016) Late clinical outcomes for SeQuent please paclitaxel-coated balloons in PCI of instent restenosis and de novo lesions: A single-center, real world registry. Catheterization and cardiovascular interventions : official journal of the Society for Cardiac Angiography & Interventionsd.o.i: 10.1002/ccd.26546
PMC: ^27113534

Heider, M. R., Gu, M., Duffy, C. M., Mirza, A. M., Marcotte, L. L., Walls, A. C., Farrall, N., Hakhverdyan, Z., Field, M. C., Rout, M. P., Frost, A. and Munson, M. (2016) Subunit connectivity, assembly determinants and architecture of the yeast exocyst complex. Nature structural & molecular biology. 23, 59-66
d.o.i: 10.1038/nsmb.3146
PMID: 4752824
PMC: ^26656853

Herrera, L. J., Brand, S., Santos, A., Nohara, L. L., Harrison, J., Norcross, N. R., Thompson, S., Smith, V., Lema, C., Varela-Ramirez, A., Gilbert, I. H., Almeida, I. C. and Maldonado, R. A. (2016) Validation of N-myristoyltransferase as Potential Chemotherapeutic Target in Mammal-Dwelling Stages of Trypanosoma cruzi. PLoS neglected tropical diseases. 10, e0004540
d.o.i: 10.1371/journal.pntd.0004540
PMC: ^27128971

Hickerson, R. P., Speaker, T. J., Lara, M. F., Gonzalez-Gonzalez, E., Flores, M. A., Contag, C. H. and Kaspar, R. L. (2016) Non-Invasive Intravital Imaging of siRNA-Mediated Mutant Keratin Gene Repression in Skin. Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging. 18, 34-42
d.o.i: 10.1007/s11307-015-0875-z
PMC: ^26169581

Horn, D. (2016) How Antiparasitic Drugs Work-And Sometimes Stop Working! PLoS pathogens. 12, e1005430
d.o.i: 10.1371/journal.ppat.1005430
PMID: 4858281
PMC: ^27149375

Hung, A. W., Silvestre, H. L., Wen, S., George, G. P., Boland, J., Blundell, T. L., Ciulli, A. and Abell, C. (2016) Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis. ChemMedChem. 11, 38-42
d.o.i: 10.1002/cmdc.201500414
PMID: 4949533
PMC: ^26486566

Jackson, A. P., Otto, T. D., Aslett, M., Armstrong, S. D., Bringaud, F., Schlacht, A., Hartley, C., Sanders, M., Wastling, J. M., Dacks, J. B., Acosta-Serrano, A., Field, M. C., Ginger, M. L. and Berriman, M. (2016) Kinetoplastid Phylogenomics Reveals the Evolutionary Innovations Associated with the Origins of Parasitism. Current biology : CB. 26, 161-172
d.o.i: 10.1016/j.cub.2015.11.055
PMID: 4728078
PMC: ^26725202

Jager, F., Zoltner, M., Kneuper, H., Hunter, W. N. and Palmer, T. (2016) Membrane interactions and self-association of components of the Ess/Type VII secretion system of Staphylococcus aureus. FEBS letters. 590, 349-357
d.o.i: 10.1002/1873-3468.12065
PMID: 4949537
PMC: ^26785823

Kalb, L. C., Frederico, Y. C., Boehm, C., Moreira, C. M., Soares, M. J. and Field, M. C. (2016) Conservation and divergence within the clathrin interactome of Trypanosoma cruzi. Scientific reports. 6, 31212
d.o.i: 10.1038/srep31212
PMID: 4977521
PMC: ^27502971

Kaspar, R. L., Hickerson, R. P., Gonzalez-Gonzalez, E., Flores, M. A., Speaker, T. P., Rogers, F. A., Milstone, L. M. and Contag, C. H. (2016) Imaging Functional Nucleic Acid Delivery to Skin. Methods in molecular biology. 1372, 1-24
d.o.i: 10.1007/978-1-4939-3148-4_1
PMC: ^26530911

Kelleher, M. M., Dunn-Galvin, A., Gray, C., Murray, D. M., Kiely, M., Kenny, L., McLean, W. H., Irvine, A. D. and Hourihane, J. O. (2016) Skin barrier impairment at birth predicts food allergy at 2 years of age. The Journal of allergy and clinical immunology. 137, 1111-1116 e1111-1118
d.o.i: 10.1016/j.jaci.2015.12.1312
PMC: ^26924469

Kennedy, E. A., Connolly, J., Hourihane, J. O., Fallon, P. G., McLean, W. H., Murray, D., Jo, J. H., Segre, J. A., Kong, H. H. and Irvine, A. D. (2016) Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year. The Journal of allergy and clinical immunologyd.o.i: 10.1016/j.jaci.2016.07.029
PMC: ^27609659

Klinger, C. M., Ramirez-Macias, I., Herman, E. K., Turkewitz, A. P., Field, M. C. and Dacks, J. B. (2016) Resolving the homology-function relationship through comparative genomics of membrane-trafficking machinery and parasite cell biology. Molecular and biochemical parasitologyd.o.i: 10.1016/j.molbiopara.2016.07.003
PMC: ^27444378

Koreny, L. and Field, M. C. (2016) Ancient Eukaryotic Origin and Evolutionary Plasticity of Nuclear Lamina. Genome biology and evolution. 8, 2663-2671
d.o.i: 10.1093/gbe/evw087
PMC: ^27189989

Larance, M., Kirkwood, K. J., Tinti, M., Brenes Murillo, A., Ferguson, M. A. and Lamond, A. I. (2016) Global Membrane Protein Interactome Analysis using In vivo Crosslinking and Mass Spectrometry-based Protein Correlation Profiling. Molecular & cellular proteomics : MCP. 15, 2476-2490
d.o.i: 10.1074/mcp.O115.055467
PMID: 4937518
PMC: ^27114452

Leitch, C. S., Natafji, E., Yu, C., Abdul-Ghaffar, S., Madarasingha, N., Venables, Z. C., Chu, R., Fitch, P. M., Muinonen-Martin, A. J., Campbell, L. E., McLean, W. H., Schwarze, J., Howie, S. E. and Weller, R. B. (2016) Filaggrin-null mutations are associated with increased maturation markers on Langerhans cells. The Journal of allergy and clinical immunology. 138, 482-490 e487
d.o.i: 10.1016/j.jaci.2015.11.040
PMC: ^26934939

Maishman, L., Obado, S. O., Alsford, S., Bart, J. M., Chen, W. M., Ratushny, A. V., Navarro, M., Horn, D., Aitchison, J. D., Chait, B. T., Rout, M. P. and Field, M. C. (2016) Co-dependence between trypanosome nuclear lamina components in nuclear stability and control of gene expression. Nucleic acids researchd.o.i: 10.1093/nar/gkw751
PMC: ^27625397

McLean, W. H. (2016) Filaggrin failure - from ichthyosis vulgaris to atopic eczema and beyond. The British journal of dermatology. 175 Suppl 2, 4-7
d.o.i: 10.1111/bjd.14997
PMC: ^27667308

Mercaldi, G. F., Dawson, A., Hunter, W. N. and Cordeiro, A. T. (2016) The structure of a Trypanosoma cruzi glucose-6-phosphate dehydrogenase reveals differences from the mammalian enzyme. FEBS letters. 590, 2776-2786
d.o.i: 10.1002/1873-3468.12276
PMC: ^27391210

Moynie, L., Hope, A. G., Finzel, K., Schmidberger, J., Leckie, S. M., Schneider, G., Burkart, M. D., Smith, A. D., Gray, D. W. and Naismith, J. H. (2016) A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA. Journal of molecular biology. 428, 108-120
d.o.i: 10.1016/j.jmb.2015.10.027
PMID: 4840175
PMC: ^26562505

Norcross, N. R., Baragana, B., Wilson, C., Hallyburton, I., Osuna-Cabello, M., Norval, S., Riley, J., Stojanovski, L., Simeons, F. R., Porzelle, A., Grimaldi, R., Wittlin, S., Duffy, S., Avery, V. M., Meister, S., Sanz, L., Jimenez-Diaz, B., Angulo-Barturen, I., Ferrer, S., Martinez, M. S., Gamo, F. J., Frearson, J. A., Gray, D. W., Fairlamb, A. H., Winzeler, E. A., Waterson, D., Campbell, S. F., Willis, P., Read, K. D. and Gilbert, I. H. (2016) Trisubstituted Pyrimidines as Efficacious and Fast-Acting Antimalarials. Journal of medicinal chemistry. 59, 6101-6120
d.o.i: 10.1021/acs.jmedchem.6b00028
PMID: 4947981
PMC: ^27314305

Obado, S. O., Brillantes, M., Uryu, K., Zhang, W., Ketaren, N. E., Chait, B. T., Field, M. C. and Rout, M. P. (2016) Interactome Mapping Reveals the Evolutionary History of the Nuclear Pore Complex. PLoS biology. 14, e1002365
d.o.i: 10.1371/journal.pbio.1002365
PMID: 4758718
PMC: ^26891179

Obado, S. O., Field, M. C., Chait, B. T. and Rout, M. P. (2016) High-Efficiency Isolation of Nuclear Envelope Protein Complexes from Trypanosomes. Methods in molecular biology. 1411, 67-80
d.o.i: 10.1007/978-1-4939-3530-7_3
PMC: ^27147034

Patterson, S., Wyllie, S., Norval, S., Stojanovski, L., Simeons, F. R., Auer, J. L., Osuna-Cabello, M., Read, K. D. and Fairlamb, A. H. (2016) The anti-tubercular drug delamanid as a potential oral treatment for visceral leishmaniasis. eLife. 5d.o.i: 10.7554/eLife.09744
PMID: 4878867
PMC: ^27215734

Perkin, M. R., Craven, J., Logan, K., Strachan, D., Marrs, T., Radulovic, S., Campbell, L. E., MacCallum, S. F., McLean, W. H., Lack, G., Flohr, C. and Enquiring About Tolerance Study, T. (2016) Association between domestic water hardness, chlorine, and atopic dermatitis risk in early life: A population-based cross-sectional study. The Journal of allergy and clinical immunology. 138, 509-516
d.o.i: 10.1016/j.jaci.2016.03.031
PMC: ^27241890

Roberts, A. J. and Fairlamb, A. H. (2016) The N-myristoylome of Trypanosoma cruzi. Scientific reports. 6, 31078
d.o.i: 10.1038/srep31078
PMID: 4974623
PMC: ^27492267

Runcie, A. C., Chan, K. H., Zengerle, M. and Ciulli, A. (2016) Chemical genetics approaches for selective intervention in epigenetics. Current opinion in chemical biology. 33, 186-194
d.o.i: 10.1016/j.cbpa.2016.06.031
PMC: ^27423045

Russell, S., Rahmani, R., Jones, A. J., Newson, H. L., Neilde, K., Cotillo, I., Rahmani Khajouei, M., Ferrins, L., Qureishi, S., Nguyen, N., Martinez-Martinez, M. S., Weaver, D. F., Kaiser, M., Riley, J., Thomas, J., De Rycker, M., Read, K. D., Flematti, G. R., Ryan, E., Tanghe, S., Rodriguez, A., Charman, S. A., Kessler, A., Avery, V. M., Baell, J. B. and Piggott, M. J. (2016) Hit-to-Lead Optimization of a Novel Class of Potent, Broad-Spectrum Trypanosomacides. Journal of medicinal chemistryd.o.i: 10.1021/acs.jmedchem.6b00442
PMC: ^27548560

Sarathy, J. P., Zuccotto, F., Hsinpin, H., Sandberg, L., Via, L. E., Marriner, G. A., Masquelin, T., Wyatt, P., Ray, P. and Dartois, V. (2016) Prediction of Drug Penetration in Tuberculosis Lesions. ACS infectious diseases. 2, 552-563
d.o.i: 10.1021/acsinfecdis.6b00051
PMID: 5028112
PMC: ^27626295

Schmitt, J., Schwarz, K., Baurecht, H., Hotze, M., Folster-Holst, R., Rodriguez, E., Lee, Y. A., Franke, A., Degenhardt, F., Lieb, W., Gieger, C., Kabesch, M., Nothen, M. M., Irvine, A. D., McLean, W. H., Deckert, S., Stephan, V., Schwarz, P., Aringer, M., Novak, N. and Weidinger, S. (2016) Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes. The Journal of allergy and clinical immunology. 137, 130-136
d.o.i: 10.1016/j.jaci.2015.06.029
PMC: ^26253344

Sekiya, A., Kono, M., Tsujiuchi, H., Kobayashi, T., Nomura, T., Kitakawa, M., Suzuki, N., Yamanaka, K., Sueki, H., McLean, W. H., Shimizu, H. and Akiyama, M. (2016) Compound heterozygotes for filaggrin gene mutations do not always show severe atopic dermatitis. Journal of the European Academy of Dermatology and Venereology : JEADVd.o.i: 10.1111/jdv.13871
PMC: ^27519469

Song, J., Baker, N., Rothert, M., Henke, B., Jeacock, L., Horn, D. and Beitz, E. (2016) Pentamidine Is Not a Permeant but a Nanomolar Inhibitor of the Trypanosoma brucei Aquaglyceroporin-2. PLoS pathogens. 12, e1005436
d.o.i: 10.1371/journal.ppat.1005436
PMID: 4734766
PMC: ^26828608

Strid, J., McLean, W. H. and Irvine, A. D. (2016) Too Much, Too Little or Just Enough: A Goldilocks Effect for IL-13 and Skin Barrier Regulation? The Journal of investigative dermatology. 136, 561-564
d.o.i: 10.1016/j.jid.2015.12.025
PMC: ^26902126

van Steensel, M. A. (2016) Making the invisible visible. Seminars in cell & developmental biology. 52, 58-65
d.o.i: 10.1016/j.semcdb.2016.02.013
PMC: ^26877141

van Steensel, M. A. (2016) The Growing Spectrum of Cutaneous RASopathy. The Journal of investigative dermatology. 136, 359-360
d.o.i: 10.1016/j.jid.2015.10.059
PMC: ^26802231

Weiss, M. S., Hunter, W. N. and Einspahr, H. M. (2016) The state-of-the art in macromolecular crystallization: the IYCr series concludes. Acta crystallographica. Section F, Structural biology communications. 72, 1
d.o.i: 10.1107/S2053230X15023742
PMID: 4708042
PMC: ^26750476

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