University of Dundee



Álvarez-Quilón A, Wojtaszek JL, Mathieu M-C, Patel T, Appel CD, Hustedt N, Rossi SE, Wallace BD, Setiaputra D, Adam S, Ohashi Y, Melo H, Cho T, Gervais C, Muñoz IM, Grazzini E, Young JTF, Rouse J, Zinda M, Williams RS, Durocher D. 2020. Endogenous DNA 3' Blocks Are Vulnerabilities for BRCA1 and BRCA2 Deficiency and Are Reversed by the APE2 Nuclease. Molecular Cell. 78:1152-1162.e1-e8.

Bustos F, Segarra-Fas A, Nardocci G, Cassidy A, Antico O, Davidson L, Brandenburg L, Macartney T, Toth R, Hastie CJ, Moran J, Gourlay R, Vargese J, Soares R, Montecino M, Findlay GM. 2020. Functional diversification of SRSF protein kinase to control ubiquitin-dependent neurodevelopmental signalling. Developmental Cell. 55:1-19.

De Cesare V, Moran J, Traynor R, Knebel A, Ritorto MS, Trost M, McLauchlan H, Hastie CJ, Davies P. 2020. High-throughput matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry–based deubiquitylating enzyme assay for drug discovery. Nature Protocols.

Deegan TD, Mukherjee PP, Fujisawa R, Polo Rivera C, Labib KPM. 2020. CMG helicase disassembly is controlled by replication fork DNA, replisome components and a ubiquitin threshold. eLife. 9:1-33.

Dunbar K, Macartney TJ, Sapkota G. 2020. IMiDs induce FAM83F degradation via an interaction with CK1α to attenuate Wnt signalling. Life Science Alliance.

Dunbar K, Jones RA, Dingwell K, Macartney TJ, Smith JC, Sapkota G. 2020. FAM83F regulates canonical Wnt signalling through an interaction with CK1α. Life Science Alliance.

Fan Y, Tonelli F, Padmanabhan S, Baptista M, Riley L, Smith D, Marras C, Howden A, Alessi D, Sammler E. 2020. Human Peripheral Blood Neutrophil Isolation for Interrogating the Parkinson’s Associated LRRK2 Kinase Pathway by Assessing Rab10 Phosphorylation. JoVE: Journal of Visualized Experiments. (157):Article e58956.

Fernandez-Alonso R, Bustos F, Budzyk M, Kumar P, Helbig AO, Hukelmann J, Lamond AI, Lanner F, Zhou H, Petsalaki E, Findlay GM. 2020. Phosphoproteomics identifies a bimodal EPHA2 receptor switch that promotes embryonic stem cell differentiation. Nature Communications. 11:Article 1357.

Fulcher L, Sapkota G. 2020. Mitotic kinase anchoring proteins: the navigators of cell division. Cell Cycle. 19(5):505-524.

Fulcher LJ, Sapkota GP. 2020. Functions and regulation of the serine/threonine protein kinase CK1 family: moving beyond promiscuity. Biochemical Journal. 477(23):4603-4321.

Gomes S, Tonelli F, Fan Y, Padmanabhan S, Baptista MAS, Riley L, Smith D, Marras C, Howden A, Alessi D, Sammler E. 2020. Isolation of human peripheral blood monocytes for LRRK2 kinase pathway analysis. JoVE: Journal of Visualized Experiments.

Hutchinson LD, Darling NJ, Nicolaou S, Gori L, Squair DR, Cohen P, Hill CS, Sapkota GP. 2020. Salt-inducible kinases (SIKs) regulate TGFβ-mediated transcriptional and apoptotic responses. Cell Death and Disease. 11:Article 49.

James OJ, Vandereyken M, Swamy M. 2020. Isolation, Characterization, and Culture of Intestinal Intraepithelial Lymphocytes. Amarnath S, editor. In Innate Lymphoid Cells: Methods and Protocols. New York: Humana Press. pp. 141-152. (Methods in Molecular Biology).

Kalogeropulou AF, Freemantle JB, Lis P, Vides EG, Polinski NK, Alessi DR. 2020. Endogenous Rab29 does not impact basal or stimulated LRRK2 pathway activity. Biochemical Journal. 477(22):4397-4423.

Karayel O, Tonelli F, Virreira Winter S, Geyer PE, Fan Y, Sammler EM, Alessi D, Steger M, Mann M. 2020. Accurate MS-based Rab10 phosphorylation stoichiometry determination as readout for LRRK2 activity in Parkinson's disease. Molecular & Cellular Proteomics. 19(9):1546-1560.

Lange S, Nelen MI, Cohen P, Kulathu Y. 2021. Dimeric structure of the pseudokinase IRAK3 suggests an allosteric mechanism for negative regulation. Structure. 29:1-14.

Mabbitt PD, Loreto A, Déry M-A, Fletcher AJ, Stanley M, Pao K-C, Wood NT, Coleman MP, Virdee S. 2020. Structural basis for RING-Cys-Relay E3 ligase activity and its role in axon integrity. Nature Chemical Biology. 16(11):1227-1236.

MacKay CI, Bick D, Prokop JW, Muñoz I, Rouse J, Downs J, Leonard H. 2020. Expanding the phenotype of the CDKL5 deficiency disorder: Are seizures mandatory?. American Journal of Medical Genetics Part A. 182(5):1217-1222.

Mathur S, Fletcher AJ, Branigan E, Hay RT, Virdee S. 2020. Photocrosslinking Activity-Based Probes for Ubiquitin RING E3 Ligases. Cell Chemical Biology. 27(1):74-82.e6.

Montava Garriga L, Ganley I. 2020. Outstanding questions in mitophagy: what we do and do not know. Journal of Molecular Biology. 342(1):206-230.

Montava-Garriga L, Singh F, Ball G, Ganley I. 2020. Semi-automated quantitation of mitophagy in cells and tissues. Mechanisms of Ageing and Development. 185:1-12.

Mullin NP, Varghese J, Colby D, Richardson JM, Findlay GM, Chambers I. 2020. Phosphorylation of NANOG by casein kinase I regulates embryonic stem cell self-renewal. FEBS Letters.

Roth S, Macartney T, Konopacka A, Chan K-H, Zhou H, Queisser MA, Sapkota G. 2020. Targeting Endogenous K-RAS for Degradation through the Affinity-Directed Protein Missile System. Cell Chemical Biology. 27(9):1151-1163.e6.

Shroff M, Knebel A, Toth R, Rouse J. 2020. A complex comprising C15ORF41 and Codanin-1- the products of two genes mutated in congenital dyserythropoietic anaemia type I (CDA-I). Biochemical Journal. 477(10):1893-1905.

Simpson LM, Macartney TJ, Nardin A, Fulcher LJ, Röth S, Testa A, Maniaci C, Ciulli A, Ganley IG, Sapkota GP. 2020. Inducible Degradation of Target Proteins through a Tractable Affinity-Directed Protein Missile System. Cell Chemical Biology. 27(9):1164-1180.e5.

Singh PK, Muqit MMK. 2020. Parkinson’s: A Disease of Aberrant Vesicle Trafficking. Annual Review of Cell and Developmental Biology. 36:237-264.

Tachie-Menson T, Gázquez-Gutiérrez A, Fulcher L, Macartney T, Wood N, Varghese J, Gourlay R, Filipe Soares R, Sapkota G. 2020. Characterisation of the biochemical and cellular roles of native and pathogenic amelogenesis imperfecta mutants of FAM83H. Cellular Signalling. 72:1-17.

Taylor M, Alessi D. 2020. Advances in elucidating the function of leucine-rich repeat protein kinase-2 in normal cells and Parkinson's disease. Current Opinion in Cell Biology. 63:102-113.

Vandereyken M, James O, Swamy M. 2020. Mechanisms of activation of innate-like intraepithelial T lymphocytes. Mucosal Immunology. 13(5):721-731.

Vieweg S, Mulholland K, Brauning B, Kacharia N, Lai Y-C, Toth R, Singh PK, Volpi I, Sattler M, Groll M, Itzen A, Muqit MMK. 2020. PINK1-dependent phosphorylation of Serine111 within the SF3 motif of Rab GTPases impairs effector interactions and LRRK2 mediated phosphorylation at Threonine72. Biochemical Journal. 477(9):1651-1668.

Waschbüsch D, Purlyte E, Pal P, McGrath E, Alessi DR, Khan AR. 2020. Structural Basis for Rab8a Recruitment of RILPL2 via LRRK2 Phosphorylation of Switch 2. Structure. 28(4):406-417.e6.

Zachari M, Rainard JM, Pandarakalam GC, Robinson L, Gillespie J, Rajamanickam M, Hamon V, Morrison A, Ganley IG, McElroy SP. 2020. The Identification and characterisation of autophagy inhibitors from the published kinase inhibitor sets. Biochemical Journal. 477(4):801-814.

Zachari M, Longo M, Ganley I. 2020. Aberrant Autophagosome Formation Occurs Upon Small Molecule Inhibition of ULK1 Kinase Activity. Life Science Alliance. 3(12):1-11.

Zhao J-F, Rodger CE, Allen GFG, Weidlich S, Ganley IG. 2020. HIF1α-dependent mitophagy facilitates cardiomyoblast differentiation. Cell Stress. 4(5):99-113.

QCRG Structural Biology Consortium, Gordon DE, Hiatt J, Bouhaddou M, Rezelj VV, Ulferts S, Braberg H, Jureka AS, Obernier K, Guo JZ, Batra J, Kaake RM, Weckstein AR, Owens TW, Gupta M, Pourmal S, Titus EW, Cakir M, Soucheray M, McGregor M, Cakir Z, Jang G, O'Meara MJ, Tummino TA, Zhang Z, Foussard H, Rojc A, Zhou Y, Kuchenov D, Hüttenhain R, Xu J, Eckhardt M, Swaney DL, Fabius JM, Ummadi M, Tutuncuoglu B, Rathore U, Modak M, Haas P, Haas KM, Williams DM, Hastie CJ, Elliott M, Brown F, Burness KA, Reid E, Baillie C, Raggett S, Toth R, Alessi DR, Davies P, García-Sastre A, Rassen JA, Grosse R, Rosenberg OS, Verba KA, Basler CF, Vignuzzi M, Peden AA, Beltrao P, Krogan NJ. 2020. Comparative host-coronavirus protein interaction networks reveal pan-viral disease mechanisms. Science (New York, N.Y.). 370(6521):Article eabe9403.