University of Dundee

Medical Research Council Protein Phosphorylation and Ubiquitylation Unit

The MRC Protein Phosphorylation and Ubiquitylation Unit (PPU) is  a major research centre that focuses on the understanding of the biological roles of  phosphorylation and ubiquitylation and how disruption of these processes cause human diseases such as neurodegeneration, cancer, hypertension and immune disorders. The ultimate goal of the Unit’s research programmes is to help develop new improved strategies to treat disease. The MRC-PPU operates as a focal point between life scientists, pharmaceutical companies and clinicians to ensure that we make a critical contribution to medical research, together reaching a deeper understanding of disease.

Principal Investigators

Professor Dario Alessi FRS FRSE
Professor of Signal Transduction and Director of MRC Protein Phosphorylation and Ubiquitylation Unit (MRC-PPU) and the Division of Signal Transduction Therapy Unit (DSTT)
Understanding signalling pathways mutated in inherited disorders
Professor Sir Philip Cohen FRS FRSE FMedSci
Professor of Enzymology and Co-Director of the Division of Signal Transduction Therapy (DSTT)
Signaling Networks that Regulate the Innate Immune System
Dr Ian Ganley
Programme Leader
Molecular analysis of autophagy
Dr. Yogesh Kulathu
Programme Leader
Ubiquitin signalling mechanisms
Professor Karim Labib FRSE
Professor of Genome Integrity
Roles and regulation of the eukaryotic replisome in preserving genome integrity and epigenetics
Dr Miratul Muqit
Wellcome Trust Senior Research Fellowship in Clinical Science and Programme Leader
Elucidation of the PINK1 signaling pathway in Parkinson’s disease
Professor John Rouse FRSE
Programme Leader in Protein Phosphorylation
Control of chromosome stability and DNA repair in health and disease
Dr Gopal Sapkota
Programme Leader in Protein Phosphorylation
Untangling the TGFβ and Wnt signalling networks in cells, development and human diseases
Dr Satpal Virdee
Programme Leader in Protein Ubiquitylation
Chemical Biology Approaches for Studying The Ubiquitin System
Professor Helen Walden
Professor of Protein Structure & Function and Programme Leader
Specificity and disease in the ubiquitin system
Dr Greg Findlay
Programme Leader
Embryonic Stem Cell Signaling Modules

Associate Principal Investigators

Dr. Mahima Swamy
Wellcome Trust and Royal Society Sir Henry Dale Fellow
Immune interactions at the intestinal epithelium