University of Dundee

MRC Protein Phosphorylation Unit 2011

Bertelsen, T., Iversen, L., Riis, J. L., Arthur, J. S., Bibby, B. M., Kragballe, K. and Johansen, C. (2011) The role of mitogen- and stress-activated protein kinase 1 and 2 in chronic skin inflammation in mice. Exp Dermatol. 20, 140-145
doi. 10.1111/j.1600-0625.2010.01153.x
Pubmed. 21166721

Bouskila, M., Esoof, N., Gay, L., Fang, E. H., Deak, M., Begley, M. J., Cantley, L. C., Prescott, A., Storey, K. G. and Alessi, D. R. (2011) TTBK2 kinase substrate specificity and the impact of spinocerebellar-ataxia-causing mutations on expression, activity, localization and development. Biochem J. 437, 157-167
doi. BJ20110276 [pii]10.1042/BJ20110276
Pubmed. 21548880

Cerezo-Guisado, M. I., Reino, P. D., Remy, G., Kuma, Y., Arthur, J. S., Gallego-Ortega, D. and Cuenda, A. (2011) Evidence of p38{gamma} and p38{delta} involvement in cell transformation processes. Carcinogenesis. 32, 1093-1099
doi. bgr079 [pii]10.1093/carcin/bgr079
Pubmed. 21558321

Chang, S., Iversen, L., Kragballe, K., Arthur, J. S. and Johansen, C. (2011) Mice Lacking MSK1 and MSK2 Show Reduced Skin Tumor Development in a Two-Stage Chemical Carcinogenesis Model. Cancer Invest. 29, 240-245
doi. 10.3109/07357907.2010.550594
Pubmed. 21314333

Chen, S., Synowsky, S., Tinti, M. and Mackintosh, C. (2011) The capture of phosphoproteins by 14-3-3 proteins mediates actions of insulin. Trends Endocrinol Metab. 22, 429-436
doi. 10.1016/j.tem.2011.07.005
Pubmed. 21871813

Chen, S., Wasserman, D. H., Mackintosh, C. and Sakamoto, K. (2011) Mice with AS160/TBC1D4-Thr649Ala Knockin Mutation Are Glucose Intolerant with Reduced Insulin Sensitivity and Altered GLUT4 Trafficking. Cell Metab. 13, 68-79
doi. S1550-4131(10)00447-X [pii]10.1016/j.cmet.2010.12.005
Pubmed. 21195350

Chiga, M., Rafiqi, F. H., Alessi, D. R., Sohara, E., Ohta, A., Rai, T., Sasaki, S. and Uchida, S. (2011) Phenotypes of pseudohypoaldosteronism type II caused by the WNK4 D561A missense mutation are dependent on the WNK-OSR1/SPAK kinase cascade. J Cell Sci. 124, 1391-1395
doi. jcs.084111 [pii]10.1242/jcs.084111
Pubmed. 21486947

Clark, K., Peggie, M., Plater, L., Sorcek, R. J., Young, E. R., Madwed, J. B., Hough, J., McIver, E. G. and Cohen, P. (2011) Novel cross-talk within the IKK family controls innate immunity. Biochem J. 434, 93-104
doi. BJ20101701 [pii]10.1042/BJ20101701
Pubmed. 21138416

Clark, K., Takeuchi, O., Akira, S. and Cohen, P. (2011) The TRAF-associated protein TANK facilitates cross-talk within the I{kappa}B kinase family during Toll-like receptor signaling. Proc Natl Acad Sci U S A. 108, 17093-17098
doi. 10.1073/pnas.1114194108
Pubmed. 21949249

Del Barco Barrantes, I., Coya, J. M., Maina, F., Arthur, J. S. and Nebreda, A. R. (2011) Genetic analysis of specific and redundant roles for p38{alpha} and p38{beta} MAPKs during mouse development. Proc Natl Acad Sci U S A. 108, 12764-12769
doi. 1015013108 [pii]10.1073/pnas.1015013108
Pubmed. 21768366

Deng, X., Dzamko, N., Prescott, A., Davies, P., Liu, Q., Yang, Q., Lee, J. D., Patricelli, M. P., Nomanbhoy, T. K., Alessi, D. R. and Gray, N. S. (2011) Characterization of a selective inhibitor of the Parkinson's disease kinase LRRK2. Nat Chem Biol. 7, 203-205
doi. nchembio.538 [pii]10.1038/nchembio.538
Pubmed. 21378983

Dissanayake, K., Toth, R., Blakey, J., Olsson, O., Campbell, D. G., Prescott, A. R. and Mackintosh, C. (2011) ERK/p90RSK/14-3-3 signalling has an impact on expression of PEA3 Ets transcription factors via the transcriptional repressor capicua. Biochem J. 433, 515-525
doi. BJ20101562 [pii]10.1042/BJ20101562
Pubmed. 21087211

Dixon, M. J., Gray, A., Boisvert, F. M., Agacan, M., Morrice, N. A., Gourlay, R., Leslie, N. R., Downes, C. P. and Batty, I. H. (2011) A Screen for Novel Phosphoinositide 3-kinase Effector Proteins. Mol Cell Proteomics. 10, M110 003178
doi. M110.003178 [pii]10.1074/mcp.M110.003178
Pubmed. 21263009

Fardilha, M., Esteves, S. L., Korrodi-Gregorio, L., Vintem, A. P., Domingues, S. C., Rebelo, S., Morrice, N., Cohen, P. T., Silva, O. A. and Silva, E. F. (2011) Identification of the human testis protein phosphatase 1 interactome. Biochem Pharmacol. 82, 1403-1415
doi. 10.1016/j.bcp.2011.02.018
Pubmed. 21382349

Filippi, B. M., de Los Heros, P., Mehellou, Y., Navratilova, I., Gourlay, R., Deak, M., Plater, L., Toth, R., Zeqiraj, E. and Alessi, D. R. (2011) MO25 is a master regulator of SPAK/OSR1 and MST3/MST4/YSK1 protein kinases. EMBO J. 30, 1730-1741
doi. emboj201178 [pii]10.1038/emboj.2011.78
Pubmed. 21423148

Garcia-Martinez, J. M., Wullschleger, S., Preston, G., Guichard, S., Fleming, S., Alessi, D. R. and Duce, S. L. (2011) Effect of PI3K- and mTOR-specific inhibitors on spontaneous B-cell follicular lymphomas in PTEN/LKB1-deficient mice. Br J Cancer. 104, 1116-1125
doi. bjc201183 [pii]10.1038/bjc.2011.83
Pubmed. 21407213

Gleason, C. E., Ordureau, A., Gourlay, R., Arthur, J. S. and Cohen, P. (2011) Polyubiquitin Binding to Optineurin Is Required for Optimal Activation of TANK-binding Kinase 1 and Production of Interferon {beta}. J Biol Chem. 286, 35663-35674
doi. 10.1074/jbc.M111.267567
Pubmed. 21862579

Gormand, A., Henriksson, E., Strom, K., Jensen, T. E., Sakamoto, K. and Goransson, O. (2011) Regulation of AMP-activated protein kinase by LKB1 and CaMKK in adipocytes. J Cell Biochem. 112, 1364-1375
doi. 10.1002/jcb.23053
Pubmed. 21312243

Green, C. J., Macrae, K., Fogarty, S., Hardie, D. G., Sakamoto, K. and Hundal, H. S. (2011) Counter modulation of fatty acid-induced proinflammatory NFkB signalling in rat skeletal muscle cells by AMPK. Biochem J. 435, 463-474
doi. BJ20101517 [pii]10.1042/BJ20101517
Pubmed. 21323644

Hunter, R. W., Treebak, J. T., Wojtaszewski, J. F. and Sakamoto, K. (2011) Molecular Mechanism by Which AMP-Activated Protein Kinase Activation Promotes Glycogen Accumulation in Muscle. Diabetes. 60, 766-774
doi. db10-1148 [pii]10.2337/db10-1148
Pubmed. 21282366

Johnson, C., Tinti, M., Wood, N. T., Campbell, D. G., Toth, R., Dubois, F., Geraghty, K. M., Wong, B. H., Brown, L. J., Tyler, J., Gernez, A., Chen, S., Synowsky, S. and Mackintosh, C. (2011) Visualization and biochemical analyses of the emerging Mammalian 14-3-3-phosphoproteome. Mol Cell Proteomics. 10, M110 005751
doi. 10.1074/mcp.M110.005751
Pubmed. 21725060

Kelsall, I. R., Voss, M., Munro, S., Cuthbertson, D. J. and Cohen, P. T. W. (2011) R3F, a novel membrane-associated glycogen targeting subunit of protein phosphatase 1 regulates glycogen synthase in astrocytoma cells in response to glucose and extracellular signals. J Neurochem. 118, 596-610
doi. 10.1111/j.1471-4159.2011.07345.x
Pubmed. 21668450

Kim, A. S., Miller, E. J., Wright, T. M., Li, J., Qi, D., Atsina, K., Zaha, V., Sakamoto, K. and Young, L. H. (2011) A small molecule AMPK activator protects the heart against ischemia-reperfusion injury. J Mol Cell Cardiol. 51, 24-32
doi. S0022-2828(11)00098-8 [pii]10.1016/j.yjmcc.2011.03.003
Pubmed. 21402077

Lewis, A. E., Sommer, L., Arntzen, M. O., Strahm, Y., Morrice, N. A., Divecha, N. and D'Santos, C. S. (2011) Identification of nuclear phosphatidylinositol 4,5-bisphosphate-interacting proteins by neomycin extraction. Mol Cell Proteomics. 10, M110 003376
doi. M110.003376 [pii]10.1074/mcp.M110.003376
Pubmed. 21048195

Lilleholt, L. L., Johansen, C., Arthur, J. S., Funding, A., Bibby, B. M., Kragballe, K. and Iversen, L. (2011) Role of p38 Mitogen-activated Protein Kinase Isoforms in Murine Skin Inflammation Induced by 12-O-tetradecanoylphorbol 13-acetate. Acta Derm Venereol. 91, 271-278
doi. 10.2340/00015555-1046
Pubmed. 21336470

Loffler, A. S., Alers, S., Dieterle, A. M., Keppeler, H., Franz-Wachtel, M., Kundu, M., Campbell, D. G., Wesselborg, S., Alessi, D. R. and Stork, B. (2011) Ulk1-mediated phosphorylation of AMPK constitutes a negative regulatory feedback loop. Autophagy. 7, 696-706
doi. 15451 [pii]
Pubmed. 21460634

Loy, B., Apostolova, G., Dorn, R., McGuire, V. A., Arthur, J. S. and Dechant, G. (2011) p38{alpha} and p38{beta} Mitogen-Activated Protein Kinases Determine Cholinergic Transdifferentiation of Sympathetic Neurons. J Neurosci. 31, 12059-12067
doi. 31/34/12059 [pii]10.1523/JNEUROSCI.0448-11.2011
Pubmed. 21865449

Mackenzie, K. F., Wallace, D. A., Hill, E. V., Anthony, D. F., Henderson, D. J., Houslay, D. M., Arthur, J. S., Baillie, G. S. and Houslay, M. D. (2011) Phosphorylation of cAMP-specific PDE4A5 (phosphodiesterase-4A5) by MK2 (MAPKAPK2) attenuates its activation through protein kinase A phosphorylation. Biochem J. 435, 755-769
doi. BJ20101184 [pii]10.1042/BJ20101184
Pubmed. 21323643

Martin, K. J., Shpiro, N., Traynor, R., Elliott, M. and Arthur, J. S. (2011) Comparison of the specificity of Trk inhibitors in recombinant and neuronal assays. Neuropharmacology. 61, 148-155
doi. S0028-3908(11)00138-9 [pii]10.1016/j.neuropharm.2011.03.021
Pubmed. 21466816

Nanda, S. K., Venigalla, R. K., Ordureau, A., Patterson-Kane, J. C., Powell, D. W., Toth, R., Arthur, J. S. and Cohen, P. (2011) Polyubiquitin binding to ABIN1 is required to prevent autoimmunity. J Exp Med. 208, 1215-1228
doi. jem.20102177 [pii]10.1084/jem.20102177
Pubmed. 21606507

Pearce, L. R., Sommer, E. M., Sakamoto, K., Wullschleger, S. and Alessi, D. R. (2011) Protor-1 is required for efficient mTORC2-mediated activation of SGK1 in the kidney. Biochem J. 436, 169-179
doi. BJ20102103 [pii]10.1042/BJ20102103
Pubmed. 21413931

Richardson, C., Sakamoto, K., de Los Heros, P., Deak, M., Campbell, D. G., Prescott, A. R. and Alessi, D. R. (2011) Regulation of the NKCC2 ion cotransporter by SPAK-OSR1-dependent and -independent pathways. J Cell Sci. 124, 789-800
doi. 124/5/789 [pii]10.1242/jcs.077230
Pubmed. 21321328

Ronkina, N., Menon, M. B., Schwermann, J., Arthur, J. S., Legault, H., Telliez, J. B., Kayyali, U. S., Nebreda, A. R., Kotlyarov, A. and Gaestel, M. (2011) Stress induced gene expression: a direct role for MAPKAP kinases in transcriptional activation of immediate early genes. Nucleic Acids Res. 39, 2503-2518
doi. gkq1178 [pii]10.1093/nar/gkq1178
Pubmed. 21109534

Smith, H. L., Liu, X. Y., Dai, L., Goh, E. T., Chan, A. T., Xi, J., Seh, C. C., Qureshi, I. A., Lescar, J., Ruedl, C., Gourlay, R., Morton, S., Hough, J., McIver, E. G., Cohen, P. and Cheung, P. C. (2011) The role of TBK1 and IKKepsilon in the expression and activation of Pellino 1. Biochem J. 434, 537-548
doi. BJ20101421 [pii]10.1042/BJ20101421
Pubmed. 21204785

Stoepker, C., Hain, K., Schuster, B., Hilhorst-Hofstee, Y., Rooimans, M. A., Steltenpool, J., Oostra, A. B., Eirich, K., Korthof, E. T., Nieuwint, A. W., Jaspers, N. G., Bettecken, T., Joenje, H., Schindler, D., Rouse, J. and de Winter, J. P. (2011) SLX4, a coordinator of structure-specific endonucleases, is mutated in a new Fanconi anemia subtype. Nat Genet. 43, 138-141
doi. ng.751 [pii]10.1038/ng.751
Pubmed. 21240277

Templeton, G. W., Nimick, M., Morrice, N., Campbell, D., Goudreault, M., Gingras, A. C., Takemiya, A., Shimazaki, K. and Moorhead, G. B. (2011) Identification and characterization of AtI-2, an Arabidopsis homologue of an ancient protein phosphatase 1 (PP1) regulatory subunit. Biochem J. 435, 73-83
doi. BJ20101035 [pii]10.1042/BJ20101035
Pubmed. 21222654

Vogt, J., Traynor, R. and Sapkota, G. P. (2011) The specificities of small molecule inhibitors of the TGFß and BMP pathways. Cell Signal. 23, 1831-1842
doi. S0898-6568(11)00191-4 [pii]10.1016/j.cellsig.2011.06.019
Pubmed. 21740966

Voss, M., Paterson, J., Kelsall, I. R., Martin-Granados, C., Hastie, C. J., Peggie, M. W. and Cohen, P. T. W. (2011) Ppm1E is an in cellulo AMP-activated protein kinase phosphatase. Cell Signal. 23, 114-124
doi. S0898-6568(10)00237-8 [pii]10.1016/j.cellsig.2010.08.010
Pubmed. 20801214

Wullschleger, S., Sakamoto, K., Johnstone, L., Duce, S., Fleming, S. and Alessi, D. R. (2011) How moderate changes in Akt T-loop phosphorylation impact on tumorigenesis and insulin resistance. Dis Model Mech. 4, 95-103
doi. dmm.005603 [pii]10.1242/dmm.005603
Pubmed. 20959631

Wullschleger, S., Wasserman, D. H., Gray, A., Sakamoto, K. and Alessi, D. R. (2011) Role of TAPP1 and TAPP2 adaptor binding to PtdIns(3,4)P2 in regulating insulin sensitivity defined by knock-in analysis. Biochem J. 434, 265-274
doi. BJ20102012 [pii]10.1042/BJ20102012
Pubmed. 21204784