University of Dundee

Understanding ubiquitination in Parkinson’s Disease

The Walden lab is focussed on uncovering the mechanisms of protein ubiquitination in health and disease. Dysfunction of several genes and proteins in the ubiquitin proteasome pathway (UPS) contribute to the pathogenesis of Parkinson’s Disease. Using a combination of structural biology and biochemistry, PhD projects are available to study how proteins are targeted for ubiquitination by proteins required for neuronal health, and what goes wrong in the disease contexts.