Biofilms are complex multicellular communities of bacteria that are involved in both chronic infection and beneficial processes. The project proposed here will investigate how the biofilm formed by the Gram-positive bacterium Bacillus subtilis is constructed. B.subtilis biofilms are waterproof because the cells make a ‘raincoat’ to protect them. We are looking for a talented student to join our lab and to study biofilm matrix assembly using a combination of biochemistry, microbial genetics and biophysics. Understanding the molecular process of biofilm matrix assembly is critical to the development of novel methodologies to disrupt biofilms.
Hobley, L.$, Ostrowski, A.$, Rao, F. $, Bromley, K., Porter, M., Prescott, A., MacPhee, C.E., van Aalten, D.M.F., Stanley-Wall, N.R. 2013 “A bacterial hydrophobin coats the Bacillus subtilis biofilm” Proceeding of the National Academy of Sciences USA vol. 110(33) pp.13600-5 doi:10.1073/pnas.1306390110 $ These authors contributed equally.
Cairns, L.S., Marlow, V. L., Bissett, E., Ostrowski, A., and Stanley-Wall, N.R. 2013 “A mechanical signal transmitted by the flagellum controls signaling in Bacillus subtilis” Molecular Microbiology vol. 90 (1) pp 6-21 doi: 10.1111/mmi.12342