University of Dundee

Immunology

CSC - Investigating immune signaling networks induced by fungal infection

Species from several fungal genera, including Candida, Aspergillus, Pneumocystis and Cryptococuss have the potential to give rise to serious clinical infections and are estimated to cause 1.5 million deaths per year.  Despite their importance as human pathogens, our understanding of how they affect immune cells, and how this might be affected by the presence of other pathogens is incomplete.

CSC - How does the HOIL-1 component of LUBAC regulate innate immunity?

The Linear Ubiquitin Assembly Complex (LUBAC) contains two E3 ubiquitin ligases, called HOIP and HOIL-1. HOIP catalyses the formation of Met1-linked ubiquitin (also called linear ubiquitin) chains, which are required to activate the IkB kinase (IKK) complex that switches on the master transcription factors of the innate immune system, NF-kB and IRF5 (interferon regulatory factor 5). In contrast, we have recently discovered that HOIL-1 is a remarkable and most unusual E3 ligase that links ubiquitin to serine and threonine residues in proteins by forming ester bonds [1].

Wellcome 4-Year PhD Programme in Integrated molecular, cellular and translational biology

Recruitment for our Wellcome 4-Year PhD Programme in Integrated molecular, cellular and translational biology is now open.  Greater than 40 different supervisors participate with diverse research areas.  Further information can be found on the programme website.  Students on this programme will carry out three short laboratory placements prior to selection of main PhD project.

Deadline for applications set as 10th January 2020