Species from several fungal genera, including Candida, Aspergillus, Pneumocystis and Cryptococuss have the potential to give rise to serious clinical infections and are estimated to cause 1.5 million deaths per year. Despite their importance as human pathogens, our understanding of how they affect immune cells, and how this might be affected by the presence of other pathogens is incomplete.
Most of our food calories come from cereal grain. The development of cereal plants strongly influences the amount of harvested grain or its yield. Cereal stems elongate when they flower (1). Tall cereals easily fall over, a devastating event for farmers, so controlling cereal height is important for cereal breeders. We recently discovered that jasmonate, a classic plant stress/defense hormone, strongly inhibits both flowering and stem elongation in barley (2), suggesting that the jasmonate pathway may be a good breeding target.
Professor Tomo Tanaka is inviting applications from bright and enthusiastic graduates for a fully-funded 3-year PhD studentship. The studentship is supported by the Cunningham Trust and will start in September 2020. The Tanaka lab is based at the Centre for Gene Regulation and Expression within the School of Life Sciences at the University of Dundee, UK (https://tomotanakalab.weebly.com). His group has been studying mechanisms of high-fidelity chromosome segregation in mitosis.
This project is offered as part of the University of Dundee 4-year MRC DTP Programme “Quantitative and Interdisciplinary approaches to biomedical science”.
Phosphorylation is a major posttranslational modification whose disruption is linked to multiple human diseases. Our lab has recently found a link between the Parkinson’s associated protein kinase PINK1 and a subset of Rab GTPases. This project will employ state-of-the-art methods to uncover the regulation of Rabs by PINK1 in cells .
The project will lead to training in a wide array of technologies including mass spectrometry and biochemistry. The lab is also linked to the EMBO network and the student will also benefit from training opportunities in Europe during their studies.
Ubiquitination is a posttranslational modification that regulates all aspects of physiology and aberrant ubiquitination has been implicated with numerous diseases. Ubiquitination is typically considered a posttranslational modification of lysine residues but it is emerging that non-lysine ubiquitination is intrinsic to mammalian biology. This project will use a multidisciplinary approach to understand the cellular function of non-lysine ubiquitination.