Eukaryotic cells make a single copy of their chromosomes in each cell cycle, using a large molecular machine known as the replisome. Unlike other cellular machines such as the ribosome or the proteasome,
University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, United Kingdom
University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, United Kingdom
University of Dundee, MRC Protein Phosphorylation and Ubiquitylation Unit, Dundee, United Kingdom
There is great need for improved understanding of the mechanistic biology underlying Parkinson’s disease.
Increasing evidence shows that alterations and mutations in the UPS give rise to various human diseases, such as cancer and neurodegenerative disorders.
The Ganley lab is interested in unravelling the molecular mechanism of autophagy (which literally translates from the Greek meaning to eat oneself).
E3 ligases are a startling class of enzyme that orchestrate the covalent attachment of the small protein ubiquitin to substrates.
