MRC Protein Phosphorylation and Ubiquitylation Unit (MRC PPU) Prize
Deciphering the mechanisms behind DNA repair pathways crucial for preventing cancers
Controlling the uncontrollables: How FAM83 proteins regulate the serine/threonine protein kinase CK1 family in cells
Molecular mechanisms underlying Parkinson's disease
Signalling pathways controlling protein degradation upon stress
Increasing evidence shows that alterations and mutations in the UPS give rise to various human diseases, such as cancer and neurodegenerative disorders. Our interest is to understand how the activity of the ubiquitin-proteasome system is regulated in cells so that accumulation of unfolded, misfolded, or damaged proteins can be cleared before they become deleterious.
Finding the eat-me signals
The Ganley lab is interested in unravelling the molecular mechanism of autophagy (which literally translates from the Greek meaning to eat oneself). Autophagy functions to clear the cell of potentially damaging agents, such as protein aggregates or faulty mitochondria, as well as acting as a recycling station to supply essential building blocks during periods of starvation.
Ubiquitin E3 ligases: function, structure and therapy
All proteins become posttranslationally modified during their lifetime and this orchestrates a large part of cellular biology. Nature’s gamut of posttranslational modifications (PTMs) is vast and the list continues to grow.