Dr Stephen Land FRSB
The following lists selected publications which show my research and teaching interests:
- Tosoni K, Cassidy D, Kerr B, Land SC, Mehta A. Using Drugs to Probe the Variability of Trans-Epithelial Airway Resistance. PLoS One. 11(2):e0149550, 2016.
- Land, S.C. D. Walker and C. L Scott. mTOR signalling, embryogenesis and the control of lung development. Semin Cell Dev Biol. 36:68-78, 2014
- Luijten NH, SG Basten, T Claessens, M Vernooij, CL Scott, R Janssen, JA. Easton, M A. F. Kamps, M Vreeburg, JLV Broers, M van Geel, FH. Menko, RP. Harbottle, RK. Nookala, AR Tee, SC. Land, R Giles, BJ. Coull, and MAM. van Steensel. Birt-Hogg-Dubé syndrome is a novel ciliopathy Hum. Mol. Genet, 22(21):4383-97, 2013.
- Watt GB, Ismail NA, Garcia Caballero A, Land SC, Wilson SM. Epithelial Na+ channel activity in human airway epithelial cells: the role of Serum and glucocorticoid-inducible kinase 1. Br J Pharmacol. 166(4):1272-89.2012.
- Dunlop, EA, KM. Dodd, SC Land, PA. Davies, N Martins, H Stuart, S McKee, C Kingswood, A Saggar, Isabel Corderio, AM Duarte Medeira, H Kingston, JR. Sampson, DM Davies and AR. Tee. Determining the Pathogenicity of Patient-Derived TSC2 Mutations by Functional Characterisation and Clinical Evidence. Eur J. Hum Genetics. 19(7):789-95, 2011.
- Preston, RS, A. Philp, T. Claesens, EA Dunlop, L. Gijezen, KT Harper, T. Brinkhuizen, M. Davies, SC Land, K. Baar, A. Pause, M van Steensel, and AR. Tee. Absence of the Birt Hogg Dubé gene product is associated with increased Hypoxia Inducible Factor transcriptional activity and a Warburg effect. Oncogene 30(10):1159-73, 2010.
- Scott CL, Walker DJ, Cwiklinski EL, Tait C, Tee AR, Land SC. Control of HIF-1 and vascular signalling in fetal lung involves cross-talk between mTORC1 and the FGF-10/FGFR2b/Spry2 airway branching periodicity clock. Am J Physiol Lung Cell Mol Physiol. 299(4):L455-71, 2010.(Editorial highlight).
- Hunter MJ, Treharne KJ, Winter AK, Cassidy DM, Land SC, Mehta A. Expression of wild-type CFTR suppresses NF-B-driven inflammatory signalling. PLoS One. 5(7):p1-9, 2010.
- Land SC, Tee AR. Hypoxia-Inducible Factor 1 is regulated by the mammalian target of rapamycin (mTOR) via an mTOR signaling motif. J Biol Chem. 282(28):20534-43, 2007.
- Land, S.C. and C. Rae. iNOS initiates and sustains metabolic arrest in hypoxic lung adenocarcinoma cells: a mechanism of cell survival in the solid tumor core. Am. J. Physiol. Cell Physiol. 289:C918-C933, 2005. (Impact factor: 3.71)
- Land, S.C. and S.M. Wilson. Redox regulation of lung development and perinatal lung epithelial function. Invited review: Antioxidants and Redox Signaling, 7(1&2):92-107, 2005.
- Land, S.C. Hochachka’s “Hypoxia Defense Strategies” and the development of the pathway for oxygen. Invited Review: Comp. Biochem. Physiol. A (Molec. Integ. Physiol).139(3): 415-433, 2004
- Land, S.C. and A. Collett. Detection of Cl- flux in the apical microenvironment of cultured foetal distal lung epithelial cells. J. Exp. Biol. 204: 785-795, 2001.
- V.M.F. Almeida-Val, A.L. Val, W.P. Duncan, F.C.A. Souza, M.N. Paula-Silva and S.C. Land. Scaling effects on hypoxia tolerance in the Amazon fish Astronotus ocellatus (Perciformes: Cichlidae): contribution of tissue enzyme levels, Comp. Biochem. Physiol. (Biochem. Mol. Biol) 125 (2): 219-226, 2000.
- Land, S.C., D.M. Porterfield, R.H. Sanger and P.J.S. Smith. The self-referencing oxygen-selective microelectrode: detection of transmembrane O2 flux from single cells. J. Exp. Biol. 202: 211-218, 1999.
- Hochachka, P.W., L.T. Buck, C.J. Doll and S.C. Land. Unifying theory of hypoxia tolerance: Molecular/metabolic defense and rescue mechanisms for surviving oxygen lack. Proc. Natl. Acad. Sci. U.S.A. 93:9493-9498, 1996.
- Land, S.C. and P.W. Hochachka. A heme-protein based oxygen-sensing mechanism controls the expression and suppression of multiple proteins in anoxia-tolerant turtle hepatocytes. Proc. Natl. Acad. Sci. USA, 92: 7505-7509, 1995.
I have oversight of the Biomedical Degree Programme which incorporates BSc degrees in Biomedical Sciences, Neurosciences, Pharmacology and Physiological Sciences. I contribute to a range of undergraduate modules within degrees spanning all years but have a specialist focus in areas related to molecular physiology, development, respiration and exercise. Beyond the School of Life Sciences, I contribute early years teaching to the MBChB and BDS programmes and assist with taught postgraduate programmes offered by the School of Medicine.
Modules I contribute teaching to:
BS11002 Introduction to the Life Sciences: why go multicellular?
BS11003 Laboratory and Research Skills 1A
BS12002 Life: the underlying structures
BS22001 Biomedical Sciences
BS22003 Laboratory and Research Skills 2C
BS31016 Practical Techniques in Biomedical Sciences [Module Manager]
BS32020 Human Epithelial Biology [Module Manager]
BS32022 Human Morphogenesis and Embryonic Development
BS41005/6 Research Skills in Biological Sciences
BS41006 Advanced Biomedical Topics/Research Communication Skills [Module Manager]
BS41007 Research Project: Biomedical Sciences [Module Manager]
BS42015 Oxygen Uptake & Utilisation [Module Manager]
DS10001 Pre- and Para-clinical Dentistry 1
MS10000 MBCHB Year 1
I started out in laboratories in the UK (Aberdeen), Canada (UBC, Vancouver) and the US (MBL, Woods Hole) that subscribed to a concept known as the “August Krogh Principle” which states that many processes contributing to human disease can be studied using organisms with naturally evolved defences to extreme conditions. For example, we studied how fish tolerate the very low oxygen levels in the Amazon River through to freeze tolerance and hibernation in freshwater frogs and turtles. This work was (and still is) relevant to several areas of medicine such as the action of anaesthetics, the preservation of organs for transplant, understanding why organs fail during heart-attack or stroke, how fuel use is regulated during periods of feast and famine and how cancerous tumours grow despite little access to nutrients or oxygen.
Many of the same processes that enable survival of harsh conditions, perhaps surprisingly, also influence organ development in pregnancy. I study how these processes influence the precisely balanced branch-like growth of the respiratory tree and promote the formation of lung defects in diseases such as Tuberous Sclerosis, Birt-Hogg-Dubé syndrome and Cystic Fibrosis. You can find out more about these research interests at https://www.researchgate.net/profile/Stephen_Land