The Blow Lab:

CR-UK Chromosome Replication Research Group

Publications 2016 -

Lachaud, C., Moreno, A., Marchesi, F., Toth, R., Blow, J.J. and Rouse, J. (2016). Ubiquitinated Fancd2 recruits Fan1 to stalled replication forks to prevent genome instability. Science 351, 846-849.  [abstract] [pdf]

Hong, Y.Y., Wang, B.U., Meier, B., Agostinho, A., Sonneville, R., Blow, J.J. and Gartner A. (2016). The SMC-5/6 complex and the HIM-6 (BLM) helicase synergistically promote meiotic recombination intermediate processing and chromosome maturation during Caenorhabditis elegans meiosis. PLoS Genetics 12, e1005872  [abstract] [pdf]

Ho, T.L.F., Guilbaud, G., Blow, J.J., Sale, J.E. and Watson, C.J. (2016). The KRAB zinc finger protein Roma/Zfp157 is a critical regulator of cell cycle progression and genomic stability. Cell Rep, 15, 724–734. [abstract] [pdf]

Gillespie, P.J., Neusiedler, J., Creavin, K. and Blow, J.J. (2016). Cell cycle synchronization in Xenopus egg extracts. Methods Mol Biol 1342, 101-147. [abstract]

Galanos, P., Vougas, K., Walter, D., Polyzos, A., Maya-Mendoza, A., Haagensen, E.J., Kokkalis, A., Roumelioti, F-M., Gagos, S., Tzetis, M., Canovas, B., Igea, A., Ahuja,  A.K., Zellweger, R., Havaki, S., Kanavakis, E., Kletsas, D., Roninson, I., Garbis, S.D., Lopes, M., Nebreda, A., Thanos, D., Blow, J.J., Townsend, P., Sørensen, C.S., Bartek, J., Gorgoulis, V.G. (2016). Chronic p53-independent p21 expression deregulates replication licensing, leading to genomic instability. Nat Cell Biol 18, 777-89. [abstract]

Singh Chadha, G. and Blow, J.J. (2016). Xenopus Mcm10 is a CDK-substrate required for replication fork stability. Cell Cycle 15, 2183-2195. [abstract] [pdf]

Moreno, A., Carrington, J.T., Albergante, L., Al Mamum, M., Haagensen, E.J., Komseli, E.-S., Gourgolis, V.G., Newman, T.J. and Blow, J.J. (2016). Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells. Proc Natl Acad Sci USA 113, E5757-64. [abstract] [pdf]

Al Mamum, M., Albergante, L., Moreno, A., Carrington, J.T., Blow, J.J. and Newman, T.J. (2016). Inevitability and containment of replication errors for eukaryotic genome lengths spanning Megabase to Gigabase. Unreplicated DNA remaining from unperturbed S phases passes through mitosis for resolution in daughter cells. Proc Natl Acad Sci USA 113, E5765–E5774. [abstract] [pdf]