The Blow Lab:

CR-UK Chromosome Replication Research Group

Publications 2011 - 2015

Kundu, L.R., Seki, M., Watanabe, N., Murofushi, H., Furukohri, A., Waga, S., Score, A.J., Blow, J.J., Horikoshi, M., Enomoto, T. and Tada, S. (2011). Biphasic chromatin binding of histone chaperone FACT during eukaryotic chromatin DNA replication. BBA-Molecular Cell Res. 1813, 1129-36. [abstract] [pdf]

Gambus, A., Khoudoli, G.A., Jones, R.C. and Blow, J.J. (2011). Mcm2-7 form double hexamers at licensed origins in Xenopus egg extract. J. Biol. Chem. 286, 11855-64. [abstract] [pdf]

Klotz-Noack, K. and Blow, J.J. (2011). A role for dormant origins in tumour suppression. Mol. Cell 41, 495-496. [abstract] [pdf]

Blow, J.J., Ge, X.Q. and Jackson, D.A. (2011). How dormant origins promote complete genome replication. Trends Biochem Sci. 6, 405-414. [abstract] [pdf]

Franz, A., Orth, M., Pirson, A.P., Sonneville, R., Blow, J.J., Gartner, A.,Stemmann, O. and Hoppe, T. (2011). CDC-48/p97 coordinates GINS chromatin Binding and CDT-1 degradation during eukaryotic DNA replication. Mol. Cell 44, 85-96. [abstract] [pdf]

Sasaki, T., Li, A., Gillespie, P.J., Blow, J.J. and Gilbert, D.M. (2011). A late-G1 phase inhibitor of replication licensing in mammalian cells that is distinct from geminin or Cdk activity. Nucleus 2, 455-464. [abstract] [pdf]

Kisielewska, J. and Blow, J.J. (2012). Dynamic interactions of high Cdt1 and geminin levels regulate S phase in early Xenopus embryos. Development 139, 63-74 [abstract] [pdf]

Sonneville, R., Querenet, M., Craig, A., Gartner, A. and Blow, J.J. (2012). The dynamics of replication licensing in live C. elegans embryos. J. Cell Biol. 196, 233-246. [abstract] [pdf]

Karschau, J., Blow, J.J. and de Moura, A.P.S. (2012). Optimal placement of origins for DNA replication. Phys. Rev. Lett.  108, 058101. [Faculty of 1000 Recommendation] [abstract] [pdf]

Klotz-Noack, K., McIntosh, D., Schurch, N., Pratt, N. and Blow, J.J. (2012). Re-replication induced by geminin depletion occurs from G2 and is enhanced by checkpoint activation. J. Cell Sci. 125, 2436-45. [abstract] [pdf]

Gillespie, P.J., Gambus, A. and Blow, J.J. (2012). Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins. Methods 57, 203-13. [abstract] [pdf]

McIntosh, D. and Blow, J.J. (2012). Dormant origins, the licensing checkpoint, and the response to replicative stresses. Cold Spring Harb Perspect Biol 4:a012955. [abstract] [pdf]

Gambus, A. and Blow, J.J. (2013). Mcm8 and Mcm9 form a dimeric complex in Xenopus laevis egg extract which is not essential for DNA replication initiation. Cell Cycle 12, 1225-32. [abstract] [pdf]

Natsume , T,. Müller, C.A., Katou, R., Retkute, R., Gierlinksi, M., Araki, H., Blow, J.J., Shirahige, K., Nieduszynski, C.A., Tanaka, T.U. (2013). Kinetochores coordinate pericentromeric cohesion and early DNA replication by Cdc7-Dbf4 kinase recruitment. Mol Cell 50, 661-674. [abstract] [pdf]

Agostinho, A., Meier, B., Sonneville, R., Jagut, M., Woglar, A., Blow J., Jantsch, V. and Gartner, A. (2013). Combinatorial regulation of Meiotic Holliday junction resolution in C. elegans by Him-6 (BLM) helicase, Slx-4, and the Slx-1, Mus-81 and Xpf-1 nucleases. PLoS Genetics e1003591. [abstract] [pdf]

Moser, S.C., Bensaddek, D., Ortmann, B., Mudie, S., Blow, J.J., Lamond, A.I., Swedlow, J.R. and Rocha, S. (2013). PHD1 links cell-cycle progression to oxygen sensing through hydroxylation of the centrosomal protein Cep192. Dev. Cell 26, 381-92. [abstract] [pdf]

Newman, T.J., Mamun, M.A., Nieduszynski, CA. and Blow, J.J. (2013). Replisome stall events have shaped the distribution of replication origins in the genomes of yeasts. Nucleic Acids Res. 41, 9705-9718. [abstract] [pdf]

Saner, N., Karschau, J., Natsume, T., Gierliński, M., Retkute, R., Hawkins, M., Nieduszynski, C.A., Blow, J.J., de Moura, A.P.S. and Tanaka, T.U. (2013). Stochastic association of neighboring replicons creates replication factories in budding yeast. J. Cell Biol. 202, 1001-1012. [abstract] [pdf]

Caillat, C., Pefani, E.-D., Gillespie, P.J., Taraviras, S., Blow, J.J., Lygerou, Z. and Perrakis, A. (2013). Idas affects the function of Geminin by heterodimerisation. J. Biol. Chem. 288, 31624-31634.  [abstract] [pdf]

Neelsen, K.J., Zanini, I.M.Y., Mijic, S., Herrador, R., Chaudhuri, A.R., Creavin, K.D., Blow, J.J. and Lopes M. (2013). Deregulated origin licensing leads to chromosomal breaks by re-replication of a gapped DNA template. Genes Dev. 27, 2537-2542. [abstract] [pdf]

Poh, W.T., Singh Chadha, G., Gillespie, P.J., Kaldis, P. and Blow, J.J. (2014). Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated Protein Phosphatase 1. Open Biology 4:130138 [abstract] [pdf]

Alver, R.C., Singh Chadha, S. and Blow, J.J. (2014). The contribution of dormant origins to genome stability: from cell biology to human genetics. DNA Repair 19, 182-189. [abstract] [pdf]

Albergante, L., Blow, J.J. and Newman, T.J. (2014). Buffered Qualitative Stability explains the robustness and evolvability of transcriptional networks. eLife 3:e02863. [abstract] [pdf]

Pelisch, F., Sonneville, R., Pourkarimi, E., Agostinho, A., Blow, J.J., Gartner A. and Hay, R.T. (2014). Dynamic SUMO modification regulates chromosome segregation and cell cycle progression in Caenorhabditis elegans. Nature Comms, 5: 5485.  [abstract] [pdf]

Sonneville, R., Craig, G., Labib, K., Gartner, A. and  Blow, J.J. (2015). Both chromosome decondensation and condensation are dependent on DNA replication in C. elegans embryos. Cell Rep 12, 405-417.  [abstract] [pdf]

Gillespie, P.J., Neusiedler, J., Creavin, K. and Blow, J.J. (2015). Cell cycle synchronization in Xenopus egg extracts. Cell Cycle Oscillators, chapter 6 in Methods Mol Biol 1342, 101-147.  [abstract] [pdf]

Benatti, P., Belluti, S., Miotto, B., Neusiedler, J., Dolfini, D., Drac, M., Basile, V., Schwob, E., Mantovani, R., Blow, J.J. and Imbriano, C. (2015). Direct non transcriptional role of NF-Y in DNA replication.  BBA - Mol. Cell Res. 1863, 673-685  [abstract] [pdf]