The Blow Lab:

CR-UK Chromosome Replication Research Group

DePamphilis, M.L., Blow, J.J., Ghosh, S., Saha, T., Noguchi, K. and Vassilev, A. (2006). Regulating the licensing of DNA replication origins in the metazoa. Curr. Opinion Cell Biol. 18, 231-239. [abstract] [pdf]

Woodward, A.M, Göhler, T. Luciani, M.G., Oehlmann, M., Ge, X., Gartner, A., Jackson, D.A. and Blow, J.J. (2006). Excess Mcm2-7 license dormant origins of replication for use when replication fork progress is inhibited. J. Cell Biol. 173, 673-683. [Faculty of 1000 Recommendation] [abstract] [pdf]

Kitamura, E., Blow, J.J. and Tanaka, T.U. (2006). Live-cell imaging reveals replication of individual replicons in eukaryotic replication factories. Cell 125, 1297-1308. [Faculty of 1000 Recommendation] [abstract] [pdf]

DePamphilis M.L. and Blow, J.J. (2006). Regulating Initiation of DNA Replication in the Metazoa. In "DNA Replication in Eukaryotic Cells" (M. DePamphilis ed.; Cold Spring Harbor Press, New York), 313-334.

Davidson, I.F., Li, A. and Blow, J.J. (2006). Deregulated replication licensing causes DNA fragmentation consistent with head-to-tail fork collision. Mol. Cell 24, 433–443. [Faculty of 1000 Recommendation] [abstract] [pdf]

Costa, S. and Blow, J.J. (2007). The elusive determinants of replication origins in eukaryotes. EMBO Rep 8, 332-334. [abstract] [pdf]

Gillespie, P.J., Khoudoli, G.K., Stewart, G., Swedlow, J.R. and Blow, J.J. (2007). ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and the replication licensing system. Curr. Biol. 17, 1657–1662. [abstract] [pdf]

Porter, I.M., McClelland, S., Khoudoli, G.A., Hunter, C.J., Andersen, J.S., McAinsh, A.D., Blow, J.J. and Swedlow, J.R. (2007). Bod1, a novel centrosome and kinetochore protein required for chromosome biorientation. J. Cell Biol., 179, 187-197. [Faculty of 1000 Recommendation] [abstract] [pdf]

Davidson, I.F., Li A. and Blow, J.J. (2007). CDT1. Targeted Proteins database.

Ge, X.Q., Jackson, D.A. and Blow, J.J. (2007). Dormant origins are required for human cells to survive replicative stress. Genes Dev. 21, 3331-3341. [abstract] [pdf]

Göhler, T., Munoz, I.M., Rouse, J. and Blow, J.J. (2008). PTIP/SWIFT is required for efficient PCNA ubiquitination in response to DNA damage. DNA Repair 7, 775-87. [abstract] [pdf]

Khoudoli, G.A., Gillespie, P.J., Stewart, G., Andersen, J.S., Swedlow, J.R. and Blow, J.J. (2008). Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibition. Curr Biol 18, 838-843.  [abstract] [pdf] [supplementary data]

Bru, T., Clarke, C., McGrew, M.J., Sang, H.M., Wilmut, I. and Blow, J.J. (2008). Rapid induction of pluripotency genes after exposure of human somatic cells to mouse ES cell extracts. Exp Cell Res 314, 2634-42. [abstract] [pdf]

Blow, J.J. and Gillespie, P.J. (2008). Replication licensing and cancer - a fatal entanglement? Nat Rev Cancer 8, 799-806. [abstract] [pdf]

Blow, J.J. and Ge, X.Q. (2008). Replication forks, chromatin loops and dormant replication origins. Genome Biol 9, 244. [abstract] [pdf]

Blow, J.J. and Ge, X.Q. (2009). A model for DNA replication showing how inefficient origins safeguard against fork failure. EMBO Rep 10, 406-412.  [abstract] [pdf]

Ge, X.Q. and Blow, J.J. (2009). The licensing checkpoint opens up. Cell Cycle 8, 2320-2322.  [abstract] [pdf]

De Marco V., Gillespie P.J., Li A., Karantzelis N., Christodoulou E., Klompmaker R., van Gerwen S., Fish A., Petoukhov M.V., Iliou M.S., Lygerou Z., Medema R.H., Blow J.J., Svergun D.I., Taraviras S. and Perrakis A. (2009). Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing. Proc. Natl. Acad. Sci. USA 106, 19807-19812.  [abstract] [pdf]

Ge, X.Q. and Blow, J.J. (2009). Conserved steps in eukaryotic DNA replication. In “Molecular Themes in DNA Replication”(L. Cox ed; Royal Society of Chemistry, Cambridge) 1-21. [pdf]

Thomson A.M., Gillespie, P.J. and Blow, J.J. (2010). Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels. J Cell Biol 188, 209-221.  [abstract] [pdf]

Chadha, G.S. and Blow, J.J. (2010). Histone acetylation by Hbo1 tightens replication licensing. Mol. Cell 37, 5-6. [abstract] [pdf]

Gillespie, P.J. and Blow, J.J. (2010). Clusters, factories and domains - the complex structure of S phase comes into focus. Cell Cycle 9, 3218-3226. [abstract] [pdf]

Ge, X.Q. and Blow, J.J. (2010). Chk1 inhibits replication factory activation but allows dormant origin firing in existing factories. J Cell Biol 191, 1285–1297. [abstract] [pdf]

Publications 2006 - 2010