The Blow Lab:

CR-UK Chromosome Replication Research Group

Peter Gillespie


Tel: (+44)-1382-385833

Fax: (+44)-1382-388072


Gillespie, P.J. and Blow, J.J. (2000). Nucleoplasmin-mediated chromatin remodelling is required for Xenopus sperm nuclei to become licensed for DNA replication. Nucleic Acids Res. 28, 472-480.

Blow, J.J., Gillespie, P., Francis, D. and Jackson, D.A. (2001). Replication origins in Xenopus egg extract are 5-15 kb apart and are activated in clusters that fire at different times. J. Cell Biol. 152, 15-26.

Gillespie, P.J., Li, A. and Blow, J.J. (2001). Reconstitution of licensed replication origins on Xenopus sperm nuclei using purified proteins. BioMed Central Biochem. 2, 15.

Chapman, N.R., Webster, G.A., Gillespie, P.J., Wilson, B.J., Crouch, D.H. and Perkins, N.D. (2002). A novel form of the RelA nuclear factor kappaB subunit is induced by and forms a complex with the proto-oncogene c-Myc. Bichem J. 366, 459-69.

Gillespie, P.J., and Hirano, T. (2002). SMC proteins. Curr Biol. 12, R513.

Gillespie, P.J., and Hirano, T. (2004). Scc2 couples replication licensing to sister chromatid cohesion in Xenopus egg extracts. Curr Biol. 14, 1598-603.

Gandhi, R., Gillespie, P.J. and Hirano, T. (2006). Human Wapl is a cohesin-binding protein that promotes sister-chromatid resolution in mitotic prophase. Curr Biol. 16, 2406-17.

Gillespie, P.J., Khoudoli, G.K., Stewart, G., Swedlow, J.R. and Blow, J.J. (2007). ELYS/MEL-28 chromatin association coordinates nuclear pore complex assembly and the replication licensing system. Curr. Biol., 17:1657-1662

Khoudoli, G.A., Gillespie, P.J., Stewart, G., Andersen, J.S., Swedlow, J.R. and Blow, J.J. (2008). Temporal profiling of the chromatin proteome reveals system-wide responses to replication inhibition. Curr Biol 18, 838-843.

Blow, J.J. and Gillespie, P.J. (2008). Replication licensing and cancer - a fatal entanglement? Nat Rev Cancer 8, 799-806.

De Marco V., Gillespie P.J., Li A., Karantzelis N., Christodoulou E., Klompmaker R., van Gerwen S., Fish A., Petoukhov M.V., Iliou M.S., Lygerou Z., Medema R.H., Blow J.J., Svergun D.I., Taraviras S. and Perrakis A. (2009). Quaternary structure of the human Cdt1-Geminin complex regulates DNA replication licensing. Proc. Natl. Acad. Sci. USA 106, 19807-19812.

Thomson A.M., Gillespie, P.J. and Blow, J.J. (2010). Replication factory activation can be decoupled from the replication timing program by modulating Cdk levels. J Cell Biol. 188, 209-221.

Gillespie, P.J. and Blow, J.J. (2010). Clusters, factories and domains - the complex structure of S phase comes into focus. Cell Cycle 9, 3218-3226.

Sasaki, T., Li, A., Gillespie, P.J., Blow, J.J. and Gilbert, D.M. (2011). A late-G1 phase inhibitor of replication licensing in mammalian cells that is distinct from geminin or Cdk activity. Nucleus 2, 455-464.

Gillespie, P.J., Gambus, A. and Blow, J.J. (2012). Preparation and use of Xenopus egg extracts to study DNA replication and chromatin associated proteins. Methods 57:203-13.

Caillat, C., Pefani, E.-D., Gillespie, P.J., Taraviras, S., Blow, J.J., Lygerou, Z. and Perrakis, A. (2013). Idas affects the function of Geminin by heterodimerisation. J. Biol. Chem.  288, 31624-31634.

Poh, W.T., Singh Chadha, G., Gillespie, P.J., Kaldis, P. and Blow, J.J. Xenopus Cdc7 executes its essential function early in S phase and is counteracted by checkpoint-regulated Protein Phosphatase 1. Open Biolog 4, 130138.

Gillespie, P.J., Neusiedler, J., Creavin, K. and Blow, J.J. (2015). Cell cycle synchronization in Xenopus egg extracts. Cell Cycle Oscillators, chapter 6 in Methods Mol Biol 1342, 101-147.

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