Wednesday, March 14, 2018 - 13:00
CTIR Sir Kenneth and Lady Noreen Murray Seminar room
Professor Simon Arthur
Dr Martin Turner
Division of Cell Signalling and Immunology and Tayside Immunology Group
RNA binding proteins (RBPs) play essential roles in the development and function of the lymphocytes. RBP are essential components of mechanisms that promote immune immunity, maintain immune tolerance and limit inflammation. RBP interact dynamically with RNA to control its biogenesis and turnover by transcription-dependent and -independent mechanisms. I will discuss data we have gained from studies using mouse models, and in some cases insights into molecular mechanisms by which RBPs allow gene expression changes to take place at different speeds and to varying degrees.