University of Dundee

"Cellular mechanotransduction: basic science and cardiovascular applications"

Event Date: 
Thursday, November 9, 2017 - 13:00
Event Location: 
MSI Small Lecture Theatre
Host: 
Professor Inke Nathke
Event Speaker: 
Dr Martin Schwartz
Institution: 
Yale University
Event Type: 
Seminar
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Martin Schwartz earned a PhD in physical chemistry from Stanford University with Harden McConnell and did postdoctoral research in biology at MIT with Richard Hynes. He has been on the faculty of Harvard Medical School, Scripps Research Institute and the University of Virginia, and now Yale University where is he is the Robert W. Berliner Professor in the Departments of Internal Medicine (Cardiology), Cell Biology and Biomedical Engineering. His current research focuses on cellular and biophysical approaches to basic questions in integrin signaling and mechanotransduction in the vascular system. Major goals of his research are to understand the fundamental biophysical mechanisms that allow cells to sense extracellular matrix stiffness and strain. A particular focus are the fundamental biophysical mechanisms by which endothelial cells sense fluid shear stress and the molecular processes that contribute to tissue remodeling, development and disease. In addition, to novel insights into these processes, he has contributed important reagents to the community. Specifically, he developed biochemical assays for measuring activation of small GTPases as well as fluorescent tension sensors for measuring forces across proteins.