University of Dundee

Senior Medicinal Chemistry Team Leader

Unit: 
Drug Discovery Unit
Job Reference: 
SLSC0584
Closing Date: 
Monday, June 10, 2019
Salary: 
Please refer to advert

Grade 8 (£40,792-£48,677) or  Grade 9 (£51,630 - £58,089), Salary dependent on experience; Open ended contract

We are seeking a highly motivated and expert medicinal chemist with experience in the BioPharma industry or similar, for a key leadership role within the Drug Discovery Unit (DDU). Work will cover from hit validation through to identifying leads demonstrating appropriate pharmaceutical properties and efficacy in pre-clinical models of disease, and to pre-clinical candidates. The appointee will plan and lead multidisciplinary projects, co-ordinate the work of a team of chemists, and will be responsible for interactions with collaborators.

The appointee will play a major role in delivering our drug discovery programmes, setting strategy, and ensuring goals and milestones are met. She/ he will line manage, and drive interactions between medicinal chemists, biologists, computational chemists and drug metabolism & pharmacokinetics experts within the DDU team and managing interactions and scientific work with multiple external collaborators. If appointed at Grade 9, you will be part of the DDU Management Team and be involved in setting DDU overall strategies and goals.

The successful applicant will join a dynamic and multidisciplinary group that covers all aspects of drug discovery up to candidate selection.

The Drug Discovery Unit (DDU) (see http://www.drugdiscovery.dundee.ac.uk) is a fully integrated drug discovery operation based within a world class Life Sciences research environment.  The DDU is housed in a state-of-the-art building with cutting-edge equipment and automation for drug discovery. Its remit is to complement BioPharma activities by tackling early stage small molecule drug discovery across a range of potential therapeutic areas including neglected diseases (leishmaniasis, malaria, tuberculosis) and cancer, neurodegeneration etc.  The DDU works to Biotech style philosophy and standards incorporating, dynamic, goal driven project management based on Target Product Profiles and Compound Selection Criteria.  The project goals are therapeutic area dependent but range from quality leads demonstrating disease model proof of concept, through to pre-clinical candidates.

This open ended post is available immediately. Salary will depend on experience, but will be in the range £40,792-£58,089.

Your primary responsibilities:

Grade 8

• Work within interdisciplinary teams and actively contribute to drug discovery projects at all stages.

• Lead hit validation to lead optimisation medicinal chemistry projects, to identify leads and preclinical candidates respectively demonstrating appropriate pharmaceutical properties and efficacy in disease models.

• Lead a team of medicinal chemists.

• Oversee outsourced chemistry.

In addition for Grade 9

• Lead interdisciplinary teams and drive drug discovery projects at all stages.

• Provide input into the long-term (5-10 year) strategic and tactical development of the DDU as member of the DDU Management Team

• Identify new methodologies/equipment to enhance the delivery of the DDU and deliver successful grant applications to expand existing infrastructure

Candidates must be professionally qualified with a PhD in a chemical science related discipline or alternatively a BSc in a chemistry related subject with subsequent substantial relevant drug discovery experience in the BioPharma industry or related.

A few facts about The School of Life Sciences at Dundee:

• The School of Life Sciences has over 900 research and support staff from 59 countries and external funding in excess of £40 million per year.

• Dundee has twice been named ‘the best place to work in Europe’ in a poll of scientists conducted by The Scientist magazine.

• The School of Life Sciences has been consistently rated ‘5-star’ (the highest rating) by the UK national Research Assessment Exercise.

We are one of the UK’s leading universities – internationally recognised for our expertise across a range of disciplines and research breakthroughs in multiple areas, including science, medicine and engineering, amongst many others. Conveniently located on the banks of River Tay, our main city centre campus is at the heart of Dundee - an up-and-coming, friendly, compact and affordable city with a rich heritage of design and technology.

The diversity of our staff and students helps to make the University of Dundee one of the top universities in the UK. Family friendly policies, staff support networks for BME and LGBT staff, membership of Athena SWAN and Stonewall, as well a full range of disability services, create an enjoyable and inclusive place to work.

Dundee, set on the east coast of Scotland, lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills. Dundee is also a vibrant cultural centre. Home to the new V&A Dundee, opened in September 2018 and already hosting its 500,000 visitor; the Dundee Rep and Scottish Dance Theatre; Dundee Contemporary Arts; MacManus Gallery and many individual artists.

For further information about the local area and the top reasons to live and work in Dundee and Scotland.

https://www.seedundee.com/category/see/

https://www.visitscotland.com/ebrochures/en/what-to-see-and-do/perthshireanddundee/

https://www.talentscotland.com/live/lifestyle/top-reasons-to-live-and-work-in-scotland

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