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The laboratory of Dr. Federico Pelisch is seeking a highly motivated postdoctoral applicant to study the regulation of chromosome segregation during meiosis in oocytes. Specifically, the project focuses on the cross-talk between SUMOylation and phosphorylation during meiosis I, with an emphasis on understanding how the balance between SUMO E3 ligases and proteases as well as kinases and phosphatases is achieved in vivo. The project will use the nematode C. elegans as a model. To tackle these issues, a wide range of techniques will be used, including proteomics, biochemical assays, genome editing, and different imaging methodologies.
The Pelisch lab is situated in the Centre for Gene Regulation and Expression (http://gre.dundee.ac.uk/) within the School of Life Sciences.
Pelisch, F.*; Bel Borja, L; Jaffray, E.G.; and Hay, R.T.
Sumoylation regulates protein dynamics during meiotic chromosome segregation in oocytes.
bioRxiv 584763 (2019); doi: https://doi.org/10.1101/584763.
Pelisch et al, A SUMO-dependent protein network regulates chromosome congression during oocyte meiosis. Molecular Cell (2017), 65:66-77.
Pelisch, F.* & Hay, R.T. Tools to study SUMO conjugation in C. elegans. Methods Mol Biol. 2016;1475:233-56. doi: 10.1007/978-1-4939-6358-4_17.
Pelisch et al, Dynamic SUMO modification regulates mitotic chromosome assembly and cell cycle progression in Caenorhabditis elegans. Nature Communications (2014) Dec 5;5:5485. doi: 10.1038/ncomms6485.
• PhD with outstanding academic track record.
• Strong background in biochemistry and/or cell biology.
• Strong experience with live cell imaging or single molecule fluorescence techniques
• Strong experience handling C. elegans, including crosses, microinjections.
• Capable of working in a team, but able to plan and work independently.
• Excellent communication skills and knowledge of the English language.
• Willingness to learn and apply new techniques across a broad range of disciplines and to adapt/develop novel approaches where required.
• Motivation, creativity and ability to communicate and to work with others.
Appointment as a Postdoctoral Research Assistant on the Grade 7 salary scale is dependent upon you having been awarded a PhD. An appointment may be considered if you are shortly expected to be awarded a PhD. The initial appointment will be made as a Research Assistant on the Training Grade 7 salary scale (Spinal Point 28, £31,302).
This position is available for a period of three years in the first instance.
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