University of Dundee

Medicinal Chemists - Grade 7 (2 posts)

Biological Chemistry and Drug Discovery
Job Reference: 
Closing Date: 
Friday, October 28, 2011
Grade 7 (£29,099 - £35,788)

The Drug Discovery Unit (DDU) (see is a fully integrated drug discovery operation based within a world class Life Sciences research environment. Its remit is to complement BioPharma activities by tackling both neglected diseases and early stage small molecule validation of novel targets and mechanisms across a range of potential therapeutics areas. The DDU works to Biotech style philosophy and standards incorporating, dynamic, goal driven project management based on Target Product Profiles and Compound Selection Criteria. The project goals are therapeutic area dependent but range from quality leads demonstrating disease model proof of concept, through to pre-clinical candidates.

We are looking for 2 highly motivated medicinal chemists as part of the BioPharma experienced multi-disciplinary team in the DDU. The posts will be primarily laboratory-based and you will have had a number of years experience contributing to medicinal chemistry projects.

The available posts will be within a new initiative in the field of translating novel ideas for drug targets and mechanisms into early-stage drug discovery opportunities. Work will focus on hit validation and hits to lead chemistry, to identify leads demonstrating appropriate pharmaceutical properties and efficacy in disease models.

The posts are available from 1st November 2011 for two years and salary will depend on post and experience, but will be in the range of £29,099 to £31,798.

Your responsibilities:
• Contribute to hit validation and hits to lead chemistry projects, to identify leads demonstrating appropriate pharmaceutical properties and efficacy in disease models.
Analyse assay and pharmacokinetic data to design and synthesise target compounds.

Knowledge, qualifications, skills and experience:
• Candidates must be professionally qualified with a PhD in a chemical science related discipline or a BSc in chemistry with subsequent experience of medicinal chemistry in the BioPharma industry
• Expertise in synthetic chemistry route design
• Experience and background in Biotech, CRO or Pharma industry
• Understanding and appreciation of pharmacology, metabolism, pharmaceutics and pharmacokinetics, toxicology, necessary for the lead optimisation processes is an advanatage
• Strong interpersonal, communication and presentation skills
• Good time management, organizational and communication skills.

A few facts about The College of Life Sciences at Dundee:
• The College of Life Sciences has over 900 research and support staff from 59 countries and external funding in excess of £40 million per year.
• Dundee has twice been named ‘the best place to work in Europe’ in a poll of scientists conducted by The Scientist magazine.
• The College of Life Sciences has been consistently rated ‘5-star’ (the highest rating) by the UK national Research Assessment Exercise.

Dundee, set on the east coast of Scotland, lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills.

How to Apply:
To apply on-line please visit: If you are unable to apply on-line please contact Human Resources on (01382) 386209 (answering machine) for an application pack. Please quote reference number LS0106. Closing Date: 28 October 2011.

The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community. The University of Dundee is a Scottish Registered Charity, No. SC015096.