University of Dundee

Medicinal Chemist - Grade 8

Biological Chemistry and Drug Discovery
Job Reference: 
Closing Date: 
Friday, October 28, 2011
Grade 8 (£36,862 - £44,016)

The Drug Discovery Unit (DDU) (see is a fully integrated drug discovery operation based within a world class Life Sciences research environment. Its remit is to complement BioPharma activities by tackling both neglected diseases (sleeping sickness, leishmaniasis and malaria) and early stage small molecule validation of novel targets and mechanisms across a range of potential therapeutics areas. The DDU works to Biotech style philosophy and standards incorporating, dynamic, goal driven project management based on Target Product Profiles and Compound Selection Criteria. The project goals are therapeutic area dependent but range from quality leads demonstrating disease model proof of concept, through to pre-clinical candidates.

We are looking for a highly motivated medicinal chemist as part of the BioPharma experienced multi-disciplinary team in the DDU. The post will be primarily laboratory-based and you will have had a number of years experience contributing to medicinal chemistry projects. The appointee will be a team leader overseeing the activities of the chemistry team on a day-to-day basis.

The available post will be within a new initiative in the field of translating novel ideas for drug targets and mechanisms into early-stage drug discovery opportunities. Work will focus on hit validation and hits to lead chemistry, to identify leads demonstrating appropriate pharmaceutical properties and efficacy in disease models.

The post is available from 1st November 2011 for two years and with a salary of £36,862.

Your responsibilities:
• The team leader will have day-to-day responsibility for the delivery of the project goals, helping to set the targets of the team and mentoring of the other chemistry posts.
• Contribute to hit validation and hits to lead chemistry projects, to identify leads demonstrating appropriate pharmaceutical properties and efficacy in disease models
Analyse assay and pharmacokinetic data to design and synthesise target compounds
• Write reports, presentations and publications

Knowledge, qualifications, skills and experience:
• Candidates must be professionally qualified with a PhD in a chemical science related discipline
• High-level experience and background in Biotech, CRO or Pharma industry
• Experience in managing projects and people is essential.
• Experience of managing collaborations is preferred
• Expertise in the discovery and development of drug candidates is essential.
• Understanding and appreciation of pharmacology, metabolism, pharmaceutics and pharmacokinetics, toxicology, necessary for the lead optimisation processes
• Expertise in synthetic organic chemistry route design
• Strong interpersonal, communication and presentation skills
• Demonstrate initiative, with good time management, organizational and communication skills.

A few facts about The College of Life Sciences at Dundee:
• The College of Life Sciences has over 900 research and support staff from 59 countries and external funding in excess of £40 million per year.
• Dundee has twice been named ‘the best place to work in Europe’ in a poll of scientists conducted by The Scientist magazine.
• The College of Life Sciences has been consistently rated ‘5-star’ (the highest rating) by the UK national Research Assessment Exercise.

Dundee, set on the east coast of Scotland, lies in an area of outstanding natural beauty, including large sandy beaches and challenging hills.

How to Apply:
To apply on-line please visit: If you are unable to apply on-line please contact Human Resources on (01382) 386209 (answering machine) for an application pack. Please quote reference number LS0107.  Closing Date: 28 October 2011.

The University of Dundee is committed to equal opportunities and welcomes applications from all sections of the community. The University of Dundee is a Scottish Registered Charity, No. SC015096.