Parasitic protozoa called trypanosomes synthesize sugars using an unexpected metabolic pathway called gluconeogenesis, according to a new study published in the open-access journal PLOS Pathogens. The research led by Professor David Horn's team, in particular lead author Dr Julie Kovarova, in collaboration with Professors Mike Ferguson (Dundee) and Mike Barrett (Glasgow) note that this metabolic flexibility may be essential for adaptation to environmental conditions and survival in mammalian host tissues.
Wellcome Centre for Anti-Infectives Research (CAIR)
A University of Dundee researcher has been awarded £1.5 million to investigate a parasite that leads to the death of tens of thousands of children around the world each year and blights the lives of millions more.
In a novel twist for researchers who actively develop drugs to combat tropical diseases, a group of scientists at the University of Dundee have been honoured for putting an end to a promising piece of research.
The work of scientists in some of Africa’s remotest communities is about to be transformed by the University of Dundee. A team from the University’s Wellcome Centre for Anti-Infectives Research (WCAIR) will travel to Malawi this week with crates of apparatus to be distributed to local researchers. Part of an ongoing initiative by the University’s School of Life Sciences to support scientists in the developing world, four members of staff from the WCAIR flew out to Africa on yesterday.
Researchers at the University of Dundee have identified a new drug target in parasites that cause major neglected tropical diseases, a discovery that contributes towards a global drive to eliminate these diseases by 2030.
A new preclinical candidate drug with the potential to treat visceral leishmaniasis, one of the world’s major neglected diseases, has been discovered through a close collaboration between the University of Dundee, GSK and Wellcome.
The African trypanosome causes African sleeping sickness, a hideous disease transmitted by the tsetse fly that, untreated, leads to character disintegration, comma and death. The trypanosome parasite evades the patient’s immune system by ‘antigenic variation’, which is the swapping one protective surface coat for another.
We are seeking a highly creative, proactive and energetic individual to take up a new post of Lead for the Drug Discovery Innovation Project (DDIP) at the Wellcome Centre for Anti-Infectives Research (WCAIR), University of Dundee.
A new study entitled “Proteomic Analysis of the Cell Cycle of Procylic Form Trypanosoma brucei” has just been published in Molecular and Cellular Proteomics (Crozier et al., 2018, Mol Cell Proteomics 2018 17: 1184-1195). This study resulted from a collaboration between the laboratories of Mike Ferguson (BCDD) and Angus Lamond (GRE). Trypanosoma brucei is an evolutionarily divergent eukaryotic protozoan parasite that causes human and animal trypanosomiasis (also called ‘sleeping sickness’) in sub-Saharan Africa.
Scientists from the University of Dundee will swap lab coats for hiking boots this weekend as they take on one of Scotland’s greatest wildlife trails for charity.
A team of four scientists from the University’s School of Life Sciences, hope to finish the 52 mile Cateran Trail within just five days as they aim to raise funds for Cats Protection and Re-Act Scotland.