University of Dundee

Wellcome Centre for Anti-Infectives Research (CAIR)

Horn lab challenge trypanosome energy production dogma

Parasitic protozoa called trypanosomes synthesize sugars using an unexpected metabolic pathway called gluconeogenesis, according to a new study published in the open-access journal PLOS Pathogens. The research led by Professor David Horn's team, in particular lead author Dr Julie Kovarova, in collaboration with Professors Mike Ferguson (Dundee) and Mike Barrett (Glasgow) note that this metabolic flexibility may be essential for adaptation to environmental conditions and survival in mammalian host tissues.

WCAIR’s Malawi mission to aid African science

The work of scientists in some of Africa’s remotest communities is about to be transformed by the University of Dundee. A team from the University’s Wellcome Centre for Anti-Infectives Research (WCAIR) will travel to Malawi this week with crates of apparatus to be distributed to local researchers. Part of an ongoing initiative by the University’s School of Life Sciences to support scientists in the developing world, four members of staff from the WCAIR flew out to Africa on yesterday.

International collaboration provides new insights into the fight against African sleeping sickness

The African trypanosome causes African sleeping sickness, a hideous disease transmitted by the tsetse fly that, untreated, leads to character disintegration, comma and death. The trypanosome parasite evades the patient’s immune system by ‘antigenic variation’, which is the swapping one protective surface coat for another. 

New Proteomic Study of Trypanosome Cell Cycle

A new study entitled “Proteomic Analysis of the Cell Cycle of Procylic Form Trypanosoma brucei” has just been published in Molecular and Cellular Proteomics (Crozier et al., 2018, Mol Cell Proteomics 2018 17: 1184-1195). This study resulted from a collaboration between the laboratories of Mike Ferguson (BCDD) and Angus Lamond (GRE).  Trypanosoma brucei is an evolutionarily divergent eukaryotic protozoan parasite that causes human and animal trypanosomiasis (also called ‘sleeping sickness’) in sub-Saharan Africa.

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