University of Dundee

School of Research

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"EGF-Induced Desialylation Controls Glycolipid-Lectin Dependent Endocytosis"

Glycosylation such as sialyation is essential for life and once it has occurred in the Golgi it is generally perceived to be static. Contrary to this preconceived view, we here report a rapid EGF-induced desialylation event at the cell surface, which initiates an increase in glycolipid-lectin (GL-Lect)-dependent endocytosis, though the enhanced binding of galectin-3 to desialylated glycans.

Jeffrey Williams – A tribute

Jeffrey Williams, world-leading expert on cell differentiation and a member of the division of Cell and Developmental Biology for 18 years until his retirement in 2016, died in January 2022.  

Jeff was well known and highly respected world-wide for his influential work on the molecular control of cell differentiation in the social amoebae Dictyostelium discoideum. During his career, he published 178 articles.

Martin Balcerowicz joins Plant Sciences

Martin Balcerowicz joined the School in January to establish his own laboratory in the Division of Plant Sciences. He undertakes an Independent Investigator position which will be supported by a University Research Fellowship from the Royal Society. Martin’s research focuses on how temperature affects gene expression in plants, and how such changes are translated into growth responses. Temperature change has direct agricultural impacts wherein wheat and barley, each 1 °C increase above optimal growth temperature reduces crop yield by 5-6 %.

“Spatial and metabolic regulation of hematopoietic progenitors in BM”

Abstract -  In humans the daily production of billions of new blood cells is supported by a specialized group of cells called hematopoietic stem cells (HSCs). HSCs are located in the bone marrow, where they give rise to several types of hematopoietic progenitors that in turn generate all the different blood cells necessary for life.

School Prizes presented at Review of the Year 2021

Review of the Year 2021 took place virtually today with the former Interim Dean, Inke Näthke sharing the highlights of activity within the School from 2021. Returning Dean, Julian Blow concluded the review with a look to the future where he highlighted plans for the coming year. The Review included the presentation of the annual School prizes. Here are the winners:

People’s Award

The People’s Award is for positive contributions to School culture.

New funding to boost deadly disease research

A parasitic infection that affects millions of people around the world is to be targeted by a £2.5 million drug discovery programme at the Universities of Dundee, Aberystwyth and Cardiff.

Schistosomiasis, also known as Bilharzia, is a parasitic infection caused by tiny flatworms that live within the blood vessels around either the intestines or bladder. The infection is found in many tropical and sub-tropical regions of the world and is estimated to cause more than 230 million clinical cases every year.