University of Dundee

College of Life Sciences

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‘Translating the SUMO signal into biological outputs’

Abstract: Small Ubiquitin-like Modifier (SUMO) is linked to target proteins via a pathway that is mechanistically similar, but quite distinct, from that of ubiquitin. Once SUMO is conjugated to target proteins it is recognised by effector proteins containing SUMO Interaction Motifs (SIMs) that are responsible for generating the biological outputs associated with SUMO modification.

Dundee researchers aim to unlock the physics of life

Researchers at the University of Dundee have been awarded £2.1 million from UK Research and Innovation (UKRI) to determine how thousands of cells self-organise to form the embryonic body plan.

The project, undertaken in collaboration with the University of Oxford and University College London, is one of nine funded by an £18 million investment from UKRI and Wellcome through the Physics of Life Strategic Priorities Fund.

"EGF-Induced Desialylation Controls Glycolipid-Lectin Dependent Endocytosis"

Glycosylation such as sialyation is essential for life and once it has occurred in the Golgi it is generally perceived to be static. Contrary to this preconceived view, we here report a rapid EGF-induced desialylation event at the cell surface, which initiates an increase in glycolipid-lectin (GL-Lect)-dependent endocytosis, though the enhanced binding of galectin-3 to desialylated glycans.

Jeffrey Williams – A tribute

Jeffrey Williams, world-leading expert on cell differentiation and a member of the division of Cell and Developmental Biology for 18 years until his retirement in 2016, died in January 2022.  

Jeff was well known and highly respected world-wide for his influential work on the molecular control of cell differentiation in the social amoebae Dictyostelium discoideum. During his career, he published 178 articles.

Martin Balcerowicz joins Plant Sciences

Martin Balcerowicz joined the School in January to establish his own laboratory in the Division of Plant Sciences. He undertakes an Independent Investigator position which will be supported by a University Research Fellowship from the Royal Society. Martin’s research focuses on how temperature affects gene expression in plants, and how such changes are translated into growth responses. Temperature change has direct agricultural impacts wherein wheat and barley, each 1 °C increase above optimal growth temperature reduces crop yield by 5-6 %.