University of Dundee

College of Life Sciences

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Momentous move pays dividends for graduand Aanchal

Aanchal Udaynath Pareri’s decision to give up her job and move 5,000 miles to study would have been life-changing at any time, but doing so at the height of the Covid-19 pandemic made the switch even more momentous.

Her choice to relocate from Mumbai has certainly paid off, however, as Aanchal (26) is about to undertake a PhD at the University of Dundee as she aims to fulfil her dream of becoming a cancer researcher.

Dundee-Harvard collaboration reveals blueprint of Parkinson’s targets

Scientists at the University of Dundee and Harvard Medical School have identified the key targets of an enzyme that play a critical role in protecting the brain against the development of Parkinson’s disease.

Parkinson’s disease is the fastest growing degenerative disorder of the brain. Patients develop involuntary movements and increasing disability. To date there is no cure or treatments that can slow the disease course.

Targeted Protein Degradation Reveals Secrets of Tumour Suppressor

PhD Student Seraina Blümli and colleagues from the Owen-Hughes lab show the ARID1A subunit of the BAF chromatin remodelling complex organised nucleosomes flanking pluripotency transcription factors and association of the coactivator EP300. Following degradation of ARID1A, dissociation of EP300 at enhancers is associated with downregulation of transcription and EP300 reassociation with upregulation. Few genes are directly affected but widespread indirect effects accumulate slowly to phenocopy a premalignant state.