University of Dundee

Cell Biology and Immunology

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Lilley Lab maps DNA repair enzyme in atomic detail

An enzyme crucial to the process of DNA repair in our cells has been mapped in atomic detail by researchers at the University of Dundee, the UK’s top-rated University for Biological Sciences.
DNA repair plays a key role in human diseases such as cancer. Researchers say that revealing the 3D molecular structure of a key enzyme involved in this process could be an important step towards developing future drugs.

"Nucleolin functions and targeting in tumor angiogenesis"

"Nucleolin (NCL) is a highly conserved nucleocytoplasmic multifunctional protein predominantly localized at nucleolus where it control rRNA transcription. It regulates ribosome biogenesis and cytoplasmic transport
and in the cytoplasm it is involved in mRNA stability of specific genes such as Bcl2. Interestingly nucleolin localizes to the cell surface in proliferating cells and it is a marker for tumor cells and angiogenic

"Gut reactions: Immune pathways in the intestine in health and disease."

The gastrointestinal system is one of the major sites of immunological challenge to the host immune system.  Here, the host must be able to mount protective immune responses against invading pathogenic micro-organisms but not against dietary antigens or normal beneficial enteric flora.  The Powrie group are interested in the factors that control the normal mutualistic relationship between commensal bacteria and the intestinal immune system and how this breaks down in inflammatory bowel disease.  In particular, T cell:dendritic cell interactions and cytokine networks in the in