University of Dundee

Biological Chemistry and Drug Discovery

Short Code: 
BCDD

Scientists destroy ‘undruggable’ cancer-causing protein

University of Dundee researchers have demonstrated a new method of destroying an ‘undruggable’ protein known to play a role in cancer, raising the possibility of a new therapeutic approach to the disease.

Mutations of the K-Ras protein have long been known to cause many cancers, including lung, colorectal, and pancreatic cancers, but despite decades of work by researchers across the world, an inhibitor for this protein has proven elusive. As a result, scientists have increasingly looked to novel ways of targeting K-Ras.

COVID Stories: There would be no world-leading research without our Support Staff (Part 2)

During lockdown, the School of Life Sciences at the University of Dundee was not closed. Work continued albeit on a much smaller scale than usual, with the majority of the ongoing research focussed on coronavirus. Our support staff were absolutely critical in keeping the research complex functioning to allow this important work to happen. As we have entered phase 2 of the Scottish Government’s route map out of lockdown, we look back over the past few months and the challenges that our community in the School encountered and had to overcome.

Dundee part of new consortium that will make tools to unlock disease biology

Almost twenty years after deciphering the human genome, our understanding of human disease is still far from complete. One of the most powerful and versatile tools to better understand biology and disease-relevant processes are well-characterized small chemical modulators of protein function. The newly formed public-private partnership “Enabling and Unlocking biology in the OPEN” (EUbOPEN) aims to develop high quality chemical tool compounds for 1,000 proteins (one third of the druggable proteins in the human body).

University of Dundee and Boehringer Ingelheim collaboration releases further free access PROTAC compounds on opnMe.com

Proteolysis-targeting chimera (PROTAC) compounds developed at the University of Dundee are being made available free of charge by the pharmaceutical company Boehringer Ingelheim through their scientific crowdsourcing platform opnMe.com. The opnMe portal provides free and open access to selected molecules for the scientific community aiming at accelerating research initiatives that can benefit patients with high unmet medical need.

Postdoctoral Research Assistant (Organic Medicinal Chemistry / Chemical Biology)

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

Structural Biology / Biophysics Scientists (PROTAC drug discovery)

The School of Life Sciences at the University of Dundee is a world-class academic institution with a reputation for the excellence of its research, its high quality teaching and student experience, and the strong impact of its activities outside academia. With 900 staff from over 60 countries worldwide the School provides a dynamic, multi-national, collegiate and diverse environment with state-of-the-art laboratory, technology and teaching facilities.

Dundee part of expanding international research effort against COVID-19

The University of Dundee is working with partners around the world as part of an expanding effort to rapidly repurpose existing drugs against Covid-19.

An international research network established by Scripps Research centres around ReFRAME, the world’s leading collection of drugs known to be safe in humans.

The network of collaborating scientific laboratories is aiming to leverage ReFRAME to find antiviral compounds against the novel coronavirus.

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