Light and Electron Microscopy
The current revolution in biological microscopy stems from the realisation that advances in optics and computational tools and automation make the modern microscope an instrument that can access all scales relevant to modern biology—from individual molecules all the way to whole tissues and organisms and from single snapshots to timelapse recordings sampling from milliseconds to days.
There is a pressing need to investigate gene/protein function and how this directs cell behaviour in physiologically relevant contexts.
Much of what is understood today about the functions of genes and the proteins that they encode comes from work in isolated cells maintained in culture dishes. We now need to understand these functions in physiologically relevant contexts and this means imaging live tissues.
Physics and Life Sciences Lab (PaLS)
The biggest challenges and opportunities in modern science arise at the interface between disciplines.
The fusion of life sciences and physical sciences is delivering powerful new insights into how biological processes function, and how we can combat diseases. The Physic and Life Science (PaLS) lab is a shared vision between the School of Engineering, Physics and Mathematics and the College of Life Sciences, with additional input from interdisciplinary work within the School of Medicine.
PHOQUS Interdisciplinary PhD Program
This will be achieved by training graduate Physicists and Biologists for the first time to integrate seamlessly photonics, nanotechnology, advanced spectroscopy and novel spectral regions with the latest advances in imaging and diagnostics technology. The photonics focus on new tools and sources will open up opportunities to investigate:
- the mechanisms and nuclear dynamics that control spindle formation and chromosome separation during mitosis
- cell migration dynamics and mechanics during early embryonic development
- the development of cancer in the gut