University of Dundee

2021

Akbar N, Forteath C, Hussain M, Reyskens K, Belch JJF, Lang CC, Mordi I, Bhalraam U, Arthur JSC, Khan F. 2021. Mitogen and Stress-Activated Kinases 1 and 2 Mediate Endothelial Dysfunction. International Journal of Molecular Sciences. 22(16):Article 8655. https://doi.org/10.3390/ijms22168655

Antico O, Ordureau A, Stevens M, Singh F, Nirujogi RS, Gierlinski M, Barini E, Rickwood ML, Prescott A, Toth R, Ganley IG, Harper JW, Muqit MMK. 2021. Global ubiquitylation analysis of mitochondria in primary neurons identifies endogenous Parkin targets following activation of PINK1. Science Advances. 7(46):1-21. https://doi.org/10.1126/sciadv.abj0722

B, Oudhoff MJ, Dewals BG, Layland LE, Horsnell WGC. 2021. Il4ra-independent vaginal eosinophil accumulation following helminth infection exacerbates epithelial ulcerative pathology of HSV-2 infection. Cell Host & Microbe. 29(4):579-593.e5. https://doi.org/10.1016/j.chom.2021.02.004

Benet S, Gálvez C, Drobniewski F, Kontsevaya I, Arias L, Monguió-Tortajada M, Erkizia I, Urrea V, Ong R-Y, Luquin M, Dupont M, Chojnacki J, Dalmau J, Cardona P, Neyrolles O, Lugo-Villarino G, Vérollet C, Julián E, Furrer H, Günthard HF, Crocker PR, Tapia G, Borràs FE, Fellay J, McLaren PJ, Telenti A, Cardona P-J, Clotet B, Vilaplana C, Martinez-Picado J, Izquierdo-Useros N. 2021. Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles. Journal of Extracellular Vesicles. 10(3):Article e12046. https://doi.org/10.1002/jev2.12046

Brenes A, Vandereyken M, James OJ, Watt H, Hukelmann J, Spinelli L, Dikovskaya D, Lamond AI, Swamy M. 2021. Tissue environment, not ontogeny, defines murine intestinal intraepithelial T lymphocytes. eLife. 10:Article e70055. https://doi.org/10.7554/eLife.70055

Chetty A, Darby MG, Vornewald PM, Martín-Alonso M, Filz A, Ritter M, McSorley HJ, Masson L, Smith K, Brombacher F, O'Shea MK, Cunningham AF, Ryffel

Cui L, Moraga I, Lerbs T, Van Neste C, Wilmes S, Tsutsumi N, Trotman-Grant AC, Gakovic M, Andrews S, Gotlib J, Darmanis S, Enge M, Quake S, Hitchcock IS, Piehler J, Garcia KC, Wernig G. 2021. Tuning MPL signaling to influence hematopoietic stem cell differentiation and inhibit essential thrombocythemia progenitors. Proceedings of the National Academy of Sciences of the United States of America. 118(2):Article e2017849118. https://doi.org/10.1073/pnas.2017849118

Damasio MP, Marchingo JM, Spinelli L, Hukelmann JL, Cantrell DA, Howden AJM. 2021. Extracellular signal-regulated kinase (ERK) pathway control of CD8+ T cell differentiation. Biochemical Journal. 478(1):79-98. https://doi.org/10.1042/BCJ20200661

Darling NJ, Arthur JSC, Cohen P. 2021. Salt-inducible kinases are required for the IL-33-dependent secretion of cytokines and chemokines in mast cells. Journal of Biological Chemistry. 296:Article 100428. https://doi.org/10.1016/j.jbc.2021.100428

Di Carluccio C, Forgione RE, Montefiori M, Civera M, Sattin S, Smaldone G, Fukase K, Manabe Y, Crocker PR, Molinaro A, Marchetti R, Silipo A. 2021. Behavior of glycolylated sialoglycans in the binding pockets of murine and human CD22. iScience. 24(1):Article 101998. https://doi.org/10.1016/j.isci.2020.101998

Drake JC, Wilson RJ, Laker RC, Guan Y, Spaulding HR, Nichenko AS, Shen W, Shang H, Dorn MV, Huang K, Zhang M, Bandara AB, Brisendine MH, Kashatus JA, Sharma PR, Young A, Gautam J, Cao R, Wallrabe H, Chang PA, Wong M, Desjardins EM, Hawley SA, Christ GJ, Kashatus DF, Miller CL, Wolf MJ, Periasamy A, Steinberg GR, Hardie DG, Yan Z. 2021. Mitochondria-localized AMPK responds to local energetics and contributes to exercise and energetic stress-induced mitophagy. Proceedings of the National Academy of Sciences of the United States of America. 118(37):Article e2025932118. https://doi.org/10.1073/pnas.2025932118

Grabowska J, Affandi AJ, van Dinther D, Nijen Twilhaar MK, Olesek K, Hoogterp L, Ambrosini M, Heijnen DAM, Klaase L, Hidalgo A, Asano K, Crocker PR, Storm G, van Kooyk Y, den Haan JMM. 2021. Liposome induction of CD8+ T cell responses depends on CD169+ macrophages and Batf3-dependent dendritic cells and is enhanced by GM3 inclusion. Journal of Controlled Release: Official Journal of the Controlled Release Society, and of the Japan Society of Drug Delivery System. 331:309-320. https://doi.org/10.1016/j.jconrel.2021.01.029

Hsu YW, Hsu FF, Chiang MT, Tsai DL, Li FA, Angata T, Crocker PR, Chau LY. 2021. Siglec-E retards atherosclerosis by inhibiting CD36-mediated foam cell formation. Journal of Biomedical Science. 28:Article 5. https://doi.org/10.1186/s12929-020-00698-z

James OJ, Vandereyken M, Marchingo JM, Singh F, Bray SE, Wilson J, Love AG, Swamy M. 2021. IL-15 and PIM kinases direct the metabolic programming of intestinal intraepithelial lymphocytes. Nature Communications. 12:Article 4290. https://doi.org/10.1038/s41467-021-24473-2

Lamprinaki D, Garcia-Vello P, Marchetti R, Hellmich C, McCord KA, Bowles KM, Macauley MS, Silipo A, De Castro C, Crocker PR, Juge N. 2021. Siglec-7 Mediates Immunomodulation by Colorectal Cancer-Associated Fusobacterium nucleatum ssp. animalis. Frontiers in Immunology. 12:Article 744184. https://doi.org/10.3389/fimmu.2021.744184

Lewis DA, Ly T. 2021. Cell Cycle Entry Control in Naïve and Memory CD8+ T Cells. Frontiers in Cell and Developmental Biology. 9:Article 727441. https://doi.org/10.3389/fcell.2021.727441

Lipina C, Stretton C, Hastings S, Hundal JS, Mackie K, Irving A, Hundal H. 2021. RETRACTED . Christopher Lipina, Clare Stretton, Simon Hastings, Jonathan S. Hundal, Ken Mackie, Andrew J. Irving, and Harinder S. Hundal. Regulation of MAP Kinase–Directed Mitogenic and Protein Kinase B–Mediated Signaling by Cannabinoid Receptor Type 1 in Skeletal Muscle Cells. Diabetes 2010;59:375–385. DOI: 10.2337/db09-0979. PMID: 19933999. PMCID: PMC2809953. Diabetes. 70(8):1910. https://doi.org/10.2337/db21-rt08a

Lisci M, Barton PR, Randzavola LO, Ma CY, Marchingo JM, Cantrell DA, Paupe V, Prudent J, Stinchcombe JC, Griffiths GM. 2021. Mitochondrial translation is required for sustained killing by cytotoxic T cells. Science. 374(6565). https://doi.org/10.1126/science.abe9977

Martinez-Fabregas J, Pohler E, Moraga I. 2021. Identifying cytokine signaling signatures in primary human Th-1 cells by phospho-proteomics analysis. STAR Protocols. 2(2):Article 100417. https://doi.org/10.1016/j.xpro.2021.100417

McSorley H, Smyth D. 2021. IL-33: a central cytokine in helminth infections. Seminars in Immunology. Article 101532. https://doi.org/10.1016/j.smim.2021.101532

McSorley HJ, Arthur JSC. 2021. The devil’s in the detail: cell-specific role of PPARγ in ILC2 activation by IL-33. Mucosal Immunology. 14:544-546. https://doi.org/10.1038/s41385-020-00363-6

Murugesan G, Correia VG, Palma AS, Chai W, Li C, Feizi T, Martin E, Laux B, Franz A, Fuchs K, Weigle B, Crocker PR. 2021. Siglec-15 recognition of sialoglycans on tumor cell lines can occur independently of sialyl Tn antigen expression. Glycobiology. 31(1):44-54. https://doi.org/10.1093/glycob/cwaa048

Murugesan G, Weigle B, Crocker PR. 2021. Siglec and anti-Siglec therapies. Current Opinion in Chemical Biology. 62:34-42. https://doi.org/10.1016/j.cbpa.2021.01.001

Nanda S, Prescott A, Figueras-Vadillo C, Cohen P. 2021. IKKβ is required for the formation of the NLRP3 inflammasome. EMBO Reports. 22(10):Article e50743. https://doi.org/10.15252/embr.202050743

Nefla M, Darling N, Van Gijsel Bonnello M, Cohen P, Arthur JSC. 2021. Salt Inducible Kinases 2 and 3 are required for thymic T cell development. Scientific Reports. 11:Article 21550. https://doi.org/10.1038/s41598-021-00986-0

Olateju OI, Morè L, Arthur JSC, Frenguelli BG. 2021. Mitogen and Stress-activated Protein Kinase 1 negatively regulates hippocampal neurogenesis. Neuroscience. 452:228-234. https://doi.org/10.1016/j.neuroscience.2020.11.017

Remenyi J, Naik RJ, Wang J, Razsolkov M, Verano A, Cai Q, Tan L, Toth R, Raggett S, Baillie C, Traynor R, Hastie J, Gray NS, Arthur SC. 2021. Generation of a chemical genetic model for JAK3. Scientific Reports. 11(1):Article 10093. https://doi.org/10.1038/s41598-021-89356-4

Reyes L, Sanchez-Garcia MA, Morrison T, Howden AJM, Watts ER, Arienti S, Sadiku P, Coelho P, Mirchandani AS, Zhang A, Hope D, Clark SK, Singleton J, Johnston S, Grecian R, Poon A, McNamara S, Harper I, Fourman MH, Brenes AJ, Pathak S, Lloyd A, Rodriguez Blanco G, von Kriegsheim A, Ghesquiere B, Vermaelen W, Cologna CT, Dhaliwal K, Hirani N, Dockrell DH, Whyte MKB, Griffith D, Cantrell DA, Walmsley SR. 2021. A type I IFN, prothrombotic hyperinflammatory neutrophil signature is distinct for COVID-19 ARDS¬¬¬: [version 2; peer review: 2 approved, 2 approved with reservations]. Wellcome Open Research. 6:Article 38. https://doi.org/10.12688/wellcomeopenres.16584.2

Ross SH, Rollings CM, Cantrell DA. 2021. Quantitative Analyses Reveal How Hypoxia Reconfigures the Proteome of Primary Cytotoxic T Lymphocytes. Frontiers in Immunology. 12:Article 712402. https://doi.org/10.3389/fimmu.2021.712402

Sampaio Guther ML, Prescott AR, Kuettel S, Tinti M, Ferguson MAJ. 2021. Nucleotide sugar biosynthesis occurs in the glycosomes of procyclic and bloodstream form Trypanosoma brucei. PLoS Neglected Tropical Diseases. 15(2):Article e0009132. https://doi.org/10.1371/journal.pntd.0009132

Singh F, Prescott AR, Rosewell P, Ball G, Reith AD, Ganley IG. 2021. Pharmacological rescue of impaired mitophagy in Parkinson's disease-related LRRK2 G2019S knock-in mice. eLife. 10:Article e67604. https://doi.org/10.7554/eLife.67604

Spinelli L, Marchingo JM, Nomura A, Damasio MP, Cantrell DA. 2021. Phosphoinositide 3-Kinase p110 Delta Differentially Restrains and Directs Naïve Versus Effector CD8+ T Cell Transcriptional Programs. Frontiers in Immunology. 12:Article 691997. https://doi.org/10.3389/fimmu.2021.691997

Stewart F, Cummins G, Turcanu MV, Cox BF, Prescott A, Clutton E, Newton IP, Desmulliez MPY, Thanou M, Mulvana H, Cochran S, Näthke I. 2021. Ultrasound mediated delivery of quantum dots from a proof of concept capsule endoscope to the gastrointestinal wall. Scientific Reports. 11:Article 2584. https://doi.org/10.1038/s41598-021-82240-1

Watts ER, Howden AJM, Morrison T, Sadiku P, Hukelmann JL, von Kriegsheim A, Ghesquière B, Murphy F, Mirchandani AS, Humphries DC, Grecian R, Ryan EM, Coelho P, Rodriguez-Blanco G, Plant TM, Dickinson RS, Finch AJ, Vermaelen W, Cantrell DA, Whyte MKB, Walmsley SR. 2021. Hypoxia drives murine neutrophil protein scavenging to maintain central carbon metabolism. Journal of Clinical Investigation. 131(10):Article e134073. https://doi.org/10.1172/JCI134073

Wilmes S, Jeffrey P-A, Martinez-Fabregas J, Hafer M, Fyfe PK, Pohler E, Gaggero S, Lopez-Garcia M, Lythe G, Taylor C, Guerrier T, Launay D, Mitra S, Piehler J, Molina-Paris C, Moraga Gonzalez I. 2021. Competitive binding of STATs to receptor phospho-Tyr motifs accounts for altered cytokine responses. eLife. 10:Article e66014. https://doi.org/10.7554/eLife.66014

Wu W, Lois N, Prescott AR, Brown AP, Van Gerwen V, Tassignon M-J, Richards SA, Saunter C, Jarrin M, Quinlan RA. 2021. The importance of the epithelial fibre cell interface to lens regeneration in an in vivo rat model and in a human bag-in-the-lens (BiL) sample. Experimental Eye Research. 213:Article 108808. https://doi.org/10.1016/j.exer.2021.108808