University of Dundee

Cell Signalling and Immunology 2017

Abdul-Sada, H., Muller, M., Mehta, R., Toth, R., Arthur, J. S. C., Whitehouse, A. and Macdonald, A. (2017) The PP4R1 sub-unit of protein phosphatase PP4 is essential for inhibition of NF-kappaB by merkel polyomavirus small tumour antigen. Oncotarget. 8, 25418-25432
d.o.i 10.18632/oncotarget.15836
Pubmed: 5421940
PMC: 28445980

Choi, Y. S., Horning, P., Aten, S., Karelina, K., Alzate-Correa, D., Arthur, J. S. C., Hoyt, K. R. and Obrietan, K. (2017) Mitogen- and Stress-Activated Protein Kinase 1 Regulates Status Epilepticus-Evoked Cell Death in the Hippocampus. ASN neuro. 9, 1759091417726607
d.o.i 10.1177/1759091417726607
Pubmed: 5588809
PMC: 28870089

Danne, C., Ryzhakov, G., Martinez-Lopez, M., Ilott, N. E., Franchini, F., Cuskin, F., Lowe, E. C., Bullers, S. J., Arthur, J. S. C. and Powrie, F. (2017) A Large Polysaccharide Produced by Helicobacter hepaticus Induces an Anti-inflammatory Gene Signature in Macrophages. Cell host & microbe. 22, 733-745 e735
d.o.i 10.1016/j.chom.2017.11.002
Pubmed: 5734933
PMC: 29241040

Darling, N. J., Toth, R., Arthur, J. S. and Clark, K. (2017) Inhibition of SIK2 and SIK3 during differentiation enhances the anti-inflammatory phenotype of macrophages. The Biochemical journal. 474, 521-537
d.o.i 10.1042/BCJ20160646
PMC: 27920213

Daumas, S., Hunter, C. J., Mistry, R. B., More, L., Privitera, L., Cooper, D. D., Reyskens, K. M., Flynn, H. T., Morris, R. G., Arthur, J. S. and Frenguelli, B. G. (2017) The Kinase Function of MSK1 Regulates BDNF Signaling to CREB and Basal Synaptic Transmission, But Is Not Required for Hippocampal Long-Term Potentiation or Spatial Memory. eNeuro. 4d.o.i 10.1523/ENEURO.0212-16.2017
Pubmed: 5318545
PMC: 28275711

Grzes, K. M., Swamy, M., Hukelmann, J. L., Emslie, E., Sinclair, L. V. and Cantrell, D. A. (2017) Control of amino acid transport coordinates metabolic reprogramming in T-cell malignancy. Leukemia. 31, 2771-2779
d.o.i 10.1038/leu.2017.160
Pubmed: 5729345
PMC: 28546582

Hardie, D. G. (2017) Targeting an energy sensor to treat diabetes. Science. 357, 455-456
d.o.i 10.1126/science.aao1913
PMC: 28774917

Hardie, D. G. (2017) An Oncogenic Role for the Ubiquitin Ligase UBE2O by Targeting AMPK-alpha2 for Degradation. Cancer cell. 31, 163-165
d.o.i 10.1016/j.ccell.2017.01.010
PMC: 28196589

Hardie, D. G. and Lin, S. C. (2017) AMP-activated protein kinase - not just an energy sensor. F1000Research. 6, 1724
d.o.i 10.12688/f1000research.11960.1
Pubmed: 5615778
PMC: 29034085

Hayakawa, M., Hayakawa, H., Petrova, T., Ritprajak, P., Sutavani, R. V., Jimenez-Andrade, G. Y., Sano, Y., Choo, M. K., Seavitt, J., Venigalla, R. K., Otsu, K., Georgopoulos, K., Arthur, J. S. and Park, J. M. (2017) Loss of Functionally Redundant p38 Isoforms in T Cells Enhances Regulatory T Cell Induction. The Journal of biological chemistry. 292, 1762-1772
d.o.i 10.1074/jbc.M116.764548
Pubmed: 5290950
PMC: 28011639

Heap, R. E., Hope, A. G., Pearson, L. A., Reyskens, K., McElroy, S. P., Hastie, C. J., Porter, D. W., Arthur, J. S. C., Gray, D. W. and Trost, M. (2017) Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs). SLAS discovery : advancing life sciences R & D. 22, 1193-1202
d.o.i 10.1177/2472555217717473
Pubmed: 5700774
PMC: 28692323

Ho, C. C. M., Chhabra, A., Starkl, P., Schnorr, P. J., Wilmes, S., Moraga, I., Kwon, H. S., Gaudenzio, N., Sibilano, R., Wehrman, T. S., Gakovic, M., Sockolosky, J. T., Tiffany, M. R., Ring, A. M., Piehler, J., Weissman, I. L., Galli, S. J., Shizuru, J. A. and Garcia, K. C. (2017) Decoupling the Functional Pleiotropy of Stem Cell Factor by Tuning c-Kit Signaling. Cell. 168, 1041-1052 e1018
d.o.i 10.1016/j.cell.2017.02.011
Pubmed: 5526607
PMC: 28283060

Kim, A. R., Ulirsch, J. C., Wilmes, S., Unal, E., Moraga, I., Karakukcu, M., Yuan, D., Kazerounian, S., Abdulhay, N. J., King, D. S., Gupta, N., Gabriel, S. B., Lander, E. S., Patiroglu, T., Ozcan, A., Ozdemir, M. A., Garcia, K. C., Piehler, J., Gazda, H. T., Klein, D. E. and Sankaran, V. G. (2017) Functional Selectivity in Cytokine Signaling Revealed Through a Pathogenic EPO Mutation. Cell. 168, 1053-1064 e1015
d.o.i 10.1016/j.cell.2017.02.026
Pubmed: 5376096
PMC: 28283061

Konishi, H., Kobayashi, M., Kunisawa, T., Imai, K., Sayo, A., Malissen, B., Crocker, P. R., Sato, K. and Kiyama, H. (2017) Siglec-H is a microglia-specific marker that discriminates microglia from CNS-associated macrophages and CNS-infiltrating monocytes. Glia. 65, 1927-1943
d.o.i 10.1002/glia.23204
PMC: 28836308

Lin, S. C. and Hardie, D. G. (2017) AMPK: Sensing Glucose as well as Cellular Energy Status. Cell metabolismd.o.i 10.1016/j.cmet.2017.10.009
PMC: 29153408

Lipina, C. and Hundal, H. S. (2017) The endocannabinoid system: 'NO' longer anonymous in the control of nitrergic signalling? Journal of molecular cell biology. 9, 91-103
d.o.i 10.1093/jmcb/mjx008
Pubmed: 5439392
PMC: 28130308

Lipina, C. and Hundal, H. S. (2017) Lipid modulation of skeletal muscle mass and function. Journal of cachexia, sarcopenia and muscle. 8, 190-201
d.o.i 10.1002/jcsm.12144
Pubmed: 5377414
PMC: 27897400

Lopez-Mejia, I. C., Lagarrigue, S., Giralt, A., Martinez-Carreres, L., Zanou, N., Denechaud, P. D., Castillo-Armengol, J., Chavey, C., Orpinell, M., Delacuisine, B., Nasrallah, A., Collodet, C., Zhang, L., Viollet, B., Hardie, D. G. and Fajas, L. (2017) CDK4 Phosphorylates AMPKalpha2 to Inhibit Its Activity and Repress Fatty Acid Oxidation. Molecular cell. 68, 336-349 e336
d.o.i 10.1016/j.molcel.2017.09.034
PMC: 29053957

Mazziotti, R., Baroncelli, L., Ceglia, N., Chelini, G., Sala, G. D., Magnan, C., Napoli, D., Putignano, E., Silingardi, D., Tola, J., Tognini, P., Arthur, J. S. C., Baldi, P. and Pizzorusso, T. (2017) Mir-132/212 is required for maturation of binocular matching of orientation preference and depth perception. Nature communications. 8, 15488
d.o.i 10.1038/ncomms15488
Pubmed: 5457514
PMC: 28534484

McEwan, D. G. (2017) Host-pathogen interactions and subversion of autophagy. Essays in biochemistry. 61, 687-697
d.o.i 10.1042/EBC20170058
PMC: 29233878

McGuire, V. A., Rosner, D., Ananieva, O., Ross, E. A., Elcombe, S. E., Naqvi, S., van den Bosch, M. M., Monk, C. E., Ruiz-Zorrilla Diez, T., Clark, A. R. and Arthur, J. S. (2017) Beta Interferon Production Is Regulated by p38 Mitogen-Activated Protein Kinase in Macrophages via both MSK1/2- and Tristetraprolin-Dependent Pathways. Molecular and cellular biology. 37d.o.i 10.1128/MCB.00454-16
Pubmed: 5192081
PMC: 27795299

Mendoza, J. L., Schneider, W. M., Hoffmann, H. H., Vercauteren, K., Jude, K. M., Xiong, A., Moraga, I., Horton, T. M., Glenn, J. S., de Jong, Y. P., Rice, C. M. and Garcia, K. C. (2017) The IFN-lambda-IFN-lambdaR1-IL-10Rbeta Complex Reveals Structural Features Underlying Type III IFN Functional Plasticity. Immunity. 46, 379-392
d.o.i 10.1016/j.immuni.2017.02.017
Pubmed: 5510750
PMC: 28329704

Millward, D. J., Halliday, D., Hundal, H., Taylor, P., Atherton, P., Greenhaff, P. and Smith, K. (2017) Michael John Rennie, MSc, PhD, FRSE, FHEA, 1946-2017: an appreciation of his work on protein metabolism in human muscle. The American journal of clinical nutrition. 106, 1-9
d.o.i 10.3945/ajcn.117.157818
PMC: 28566312

Moraga, I., Spangler, J. B., Mendoza, J. L., Gakovic, M., Wehrman, T. S., Krutzik, P. and Garcia, K. C. (2017) Synthekines are surrogate cytokine and growth factor agonists that compel signaling through non-natural receptor dimers. eLife. 6d.o.i 10.7554/eLife.22882
Pubmed: 5429090
PMC: 28498099

Rena, G., Hardie, D. G. and Pearson, E. R. (2017) The mechanisms of action of metformin. Diabetologia. 60, 1577-1585
d.o.i 10.1007/s00125-017-4342-z
Pubmed: 5552828
PMC: 28776086

Richter, D., Moraga, I., Winkelmann, H., Birkholz, O., Wilmes, S., Schulte, M., Kraich, M., Kenneweg, H., Beutel, O., Selenschik, P., Paterok, D., Gavutis, M., Schmidt, T., Garcia, K. C., Muller, T. D. and Piehler, J. (2017) Ligand-induced type II interleukin-4 receptor dimers are sustained by rapid re-association within plasma membrane microcompartments. Nature communications. 8, 15976
d.o.i 10.1038/ncomms15976
Pubmed: 5519985
PMC: 28706306

Rogov, V. V., Stolz, A., Ravichandran, A. C., Rios-Szwed, D. O., Suzuki, H., Kniss, A., Lohr, F., Wakatsuki, S., Dotsch, V., Dikic, I., Dobson, R. C. and McEwan, D. G. (2017) Structural and functional analysis of the GABARAP interaction motif (GIM). EMBO reports. 18, 1382-1396
d.o.i 10.15252/embr.201643587
Pubmed: 5538626
PMC: 28655748

Ross, F. A., Hawley, S. A., Auciello, F. R., Gowans, G. J., Atrih, A., Lamont, D. J. and Hardie, D. G. (2017) Mechanisms of Paradoxical Activation of AMPK by the Kinase Inhibitors SU6656 and Sorafenib. Cell chemical biology. 24, 813-824 e814
d.o.i 10.1016/j.chembiol.2017.05.021
Pubmed: 5522529
PMC: 28625738

Salt, I. P. and Hardie, D. G. (2017) AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System. Circulation research. 120, 1825-1841
d.o.i 10.1161/CIRCRESAHA.117.309633
Pubmed: 5447810
PMC: 28546359

Salvador-Bernaldez, M., Mateus, S. B., Del Barco Barrantes, I., Arthur, S. C., Martinez, A. C., Nebreda, A. R. and Salvador, J. M. (2017) p38alpha regulates cytokine-induced IFNgamma secretion via the Mnk1/eIF4E pathway in Th1 cells. Immunology and cell biology. 95, 814-823
d.o.i 10.1038/icb.2017.51
PMC: 28611474

Shinde, P. V., Xu, H. C., Maney, S. K., Kloetgen, A., Namineni, S., Zhuang, Y., Honke, N., Shaabani, N., Bellora, N., Doerrenberg, M., Trilling, M., Pozdeev, V. I., van Rooijen, N., Scheu, S., Pfeffer, K., Crocker, P. R., Tanaka, M., Duggimpudi, S., Knolle, P., Heikenwalder, M., Ruland, J., Mak, T. W., Brenner, D., Pandyra, A. A., Hoell, J. I., Borkhardt, A., Haussinger, D., Lang, K. S. and Lang, P. A. (2017) TNF-mediated survival of CD169(+) cells promotes immune activation during vesicular stomatitis virus infection. Journal of virologyd.o.i 10.1128/JVI.01637-17
PMC: 29142134

Strickson, S., Emmerich, C. H., Goh, E. T. H., Zhang, J., Kelsall, I. R., Macartney, T., Hastie, C. J., Knebel, A., Peggie, M., Marchesi, F., Arthur, J. S. C. and Cohen, P. (2017) Roles of the TRAF6 and Pellino E3 ligases in MyD88 and RANKL signaling. Proceedings of the National Academy of Sciences of the United States of America. 114, E3481-E3489
d.o.i 10.1073/pnas.1702367114
Pubmed: 5410814
PMC: 28404732

Sutavani, R. V., Phair, I. R., Barker, R., McFarlane, A., Shpiro, N., Lang, S., Woodland, A. and Arthur, J. S. C. (2017) Differential regulation of TLR4 induced IL-10 production in B cells and macrophages reveals a novel role for RSK1 and 2 in B cells. The Journal of biological chemistryd.o.i 10.1074/jbc.M117.805424
PMC: 29229781

Vara-Ciruelos, D., Dandapani, M., Gray, A., Egbani, E. O., Evans, A. M. and Hardie, D. G. (2017) Genotoxic Damage Activates the AMPK-alpha1 Isoform in the Nucleus via Ca(2+)/CaMKK2 Signaling to Enhance Tumor Cell Survival. Molecular cancer research : MCRd.o.i 10.1158/1541-7786.MCR-17-0323
PMC: 29133590

Wada, M., Canals, D., Adada, M., Coant, N., Salama, M. F., Helke, K. L., Arthur, J. S., Shroyer, K. R., Kitatani, K., Obeid, L. M. and Hannun, Y. A. (2017) P38 delta MAPK promotes breast cancer progression and lung metastasis by enhancing cell proliferation and cell detachment. Oncogene. 36, 6649-6657
d.o.i 10.1038/onc.2017.274
Pubmed: 5746050
PMC: 28783172

Wu, G., Nagala, M. and Crocker, P. R. (2017) Identification of lectin counter-receptors on cell membranes by proximity labeling. Glycobiology. 27, 800-805
d.o.i 10.1093/glycob/cwx063
PMC: 28810661

Xu, Y., Gray, A., Hardie, D. G., Uzun, A., Shaw, S., Padbury, J., Phornphutkul, C. and Tseng, Y. T. (2017) A novel, de novo mutation in the PRKAG2 gene: infantile-onset phenotype and the signaling pathway involved. American journal of physiology. Heart and circulatory physiology. 313, H283-H292
d.o.i 10.1152/ajpheart.00813.2016
Pubmed: 5582920
PMC: 28550180

Zhang, C. S., Hawley, S. A., Zong, Y., Li, M., Wang, Z., Gray, A., Ma, T., Cui, J., Feng, J. W., Zhu, M., Wu, Y. Q., Li, T. Y., Ye, Z., Lin, S. Y., Yin, H., Piao, H. L., Hardie, D. G. and Lin, S. C. (2017) Fructose-1,6-bisphosphate and aldolase mediate glucose sensing by AMPK. Nature. 548, 112-116
d.o.i 10.1038/nature23275
Pubmed: 5544942
PMC: 2872389