University of Dundee

Biological Chemistry and Drug Discovery 2017

Arora, K., B. Ochoa-Montano, P. S. Tsang, T. L. Blundell, S. S. Dawes, V. Mizrahi, T. Bayliss, C. J. Mackenzie, L. A. T. Cleghorn, P. C. Ray, P. G. Wyatt, E. Uh, J. Lee, C. E. Barry, 3rd and H. I. Boshoff (2017). "Correction for Arora et al., "Respiratory Flexibility in Response to Inhibition of Cytochrome c Oxidase in Mycobacterium tuberculosis"." Antimicrob Agents Chemother 61(9).

Bochner, R., L. Samuelov, O. Sarig, Q. Li, C. A. Adase, O. Isakov, N. Malchin, D. Vodo, R. Shayevitch, A. Peled, B. D. Yu, G. Fainberg, E. Warshauer, N. Adir, N. Erez, A. Gat, Y. Gottlieb, T. Rogers, M. Pavlovsky, I. Goldberg, N. Shomron, A. Sandilands, L. E. Campbell, S. MacCallum, W. H. McLean, G. Ast, R. L. Gallo, J. Uitto and E. Sprecher (2017). "Calpain 12 Function Revealed through the Study of an Atypical Case of Autosomal Recessive Congenital Ichthyosis." J Invest Dermatol 137(2): 385-393.

Boehm, C. M., S. Obado, C. Gadelha, A. Kaupisch, P. T. Manna, G. W. Gould, M. Munson, B. T. Chait, M. P. Rout and M. C. Field (2017). "The Trypanosome Exocyst: A Conserved Structure Revealing a New Role in Endocytosis." PLoS Pathog 13(1): e1006063.

Bortoluzzi, A., A. Amato, X. Lucas, M. Blank and A. Ciulli (2017). "Structural basis of molecular recognition of helical histone H3 tail by PHD finger domains." Biochem J 474(10): 1633-1651.

Brand, S., E. J. Ko, E. Viayna, S. Thompson, D. Spinks, M. Thomas, L. Sandberg, A. F. Francisco, S. Jayawardhana, V. C. Smith, C. Jansen, M. De Rycker, J. Thomas, L. MacLean, M. Osuna-Cabello, J. Riley, P. Scullion, L. Stojanovski, F. R. C. Simeons, O. Epemolu, Y. Shishikura, S. D. Crouch, T. S. Bakshi, C. J. Nixon, I. H. Reid, A. P. Hill, T. Z. Underwood, S. J. Hindley, S. A. Robinson, J. M. Kelly, J. M. Fiandor, P. G. Wyatt, M. Marco, T. J. Miles, K. D. Read and I. H. Gilbert (2017). "Discovery and Optimization of 5-Amino-1,2,3-triazole-4-carboxamide Series against Trypanosoma cruzi." J Med Chem 60(17): 7284-7299.

Cardote, T. A. F. and A. Ciulli (2017). "Structure-Guided Design of Peptides as Tools to Probe the Protein-Protein Interaction between Cullin-2 and Elongin BC Substrate Adaptor in Cullin RING E3 Ubiquitin Ligases." ChemMedChem 12(18): 1491-1496.

Cardote, T. A. F., M. S. Gadd and A. Ciulli (2017). "Crystal Structure of the Cul2-Rbx1-EloBC-VHL Ubiquitin Ligase Complex." Structure 25(6): 901-911 e903.

Chan, K. H., M. Zengerle, A. Testa and A. Ciulli (2017). "Impact of Target Warhead and Linkage Vector on Inducing Protein Degradation: Comparison of Bromodomain and Extra-Terminal (BET) Degraders Derived from Triazolodiazepine (JQ1) and Tetrahydroquinoline (I-BET726) BET Inhibitor Scaffolds." J Med Chem.

Crozier, T. W. M., M. Tinti, M. Larance, A. I. Lamond and M. A. J. Ferguson (2017). "Prediction of protein complexes in Trypanosoma brucei by protein correlation profiling mass spectrometry and machine learning." Mol Cell Proteomics.

De Schutter, J. W., J. P. Morrison, M. J. Morrison, A. Ciulli and B. Imperiali (2017). "Targeting Bacillosamine Biosynthesis in Bacterial Pathogens: Development of Inhibitors to a Bacterial Amino-Sugar Acetyltransferase from Campylobacter jejuni." J Med Chem 60(5): 2099-2118.

de Vos, I. J., M. Vreeburg, G. H. Koek and M. A. van Steensel (2017). "Review of familial cerebral cavernous malformations and report of seven additional families." Am J Med Genet A 173(2): 338-351.

Diaz-Saez, L., G. Pankov and W. N. Hunter (2017). "Open and compressed conformations of Francisella tularensis ClpP." Proteins 85(1): 188-194.

Ebenezer, T. E., M. Carrington, M. Lebert, S. Kelly and M. C. Field (2017). "Euglena gracilis Genome and Transcriptome: Organelles, Nuclear Genome Assembly Strategies and Initial Features." Adv Exp Med Biol 979: 125-140.

Fernandez-Alonso, R., L. Davidson, J. Hukelmann, M. Zengerle, A. R. Prescott, A. Lamond, A. Ciulli, G. P. Sapkota and G. M. Findlay (2017). "Brd4-Brd2 isoform switching coordinates pluripotent exit and Smad2-dependent lineage specification." EMBO Rep.

Field, M. C., D. Horn, A. H. Fairlamb, M. A. Ferguson, D. W. Gray, K. D. Read, M. De Rycker, L. S. Torrie, P. G. Wyatt, S. Wyllie and I. H. Gilbert (2017). "Anti-trypanosomatid drug discovery: an ongoing challenge and a continuing need." Nat Rev Microbiol 15(4): 217-231.

Fleury, O. M., M. A. McAleer, C. Feuillie, C. Formosa-Dague, E. Sansevere, D. E. Bennett, A. M. Towell, W. H. I. McLean, S. Kezic, D. A. Robinson, P. G. Fallon, T. J. Foster, Y. F. Dufrene, A. D. Irvine and J. A. Geoghegan (2017). "Clumping Factor B Promotes Adherence of Staphylococcus aureus to Corneocytes in Atopic Dermatitis." Infect Immun 85(6).

Gadd, M. S., A. Testa, X. Lucas, K. H. Chan, W. Chen, D. J. Lamont, M. Zengerle and A. Ciulli (2017). "Structural basis of PROTAC cooperative recognition for selective protein degradation." Nat Chem Biol 13(5): 514-521.

Guo, H., N. M. Novozhilova, G. Bandini, S. J. Turco, M. A. J. Ferguson and S. M. Beverley (2017). "Genetic Metabolic Complementation establishes a requirement for GDP-Fucose in Leishmania." J Biol Chem.

Hallyburton, I., R. Grimaldi, A. Woodland, B. Baragana, T. Luksch, D. Spinks, D. James, D. Leroy, D. Waterson, A. H. Fairlamb, P. G. Wyatt, I. H. Gilbert and J. A. Frearson (2017). "Screening a protein kinase inhibitor library against Plasmodium falciparum." Malar J 16(1): 446.

Heap, R. E., A. G. Hope, L. A. Pearson, K. Reyskens, S. P. McElroy, C. J. Hastie, D. W. Porter, J. S. C. Arthur, D. W. Gray and M. Trost (2017). "Identifying Inhibitors of Inflammation: A Novel High-Throughput MALDI-TOF Screening Assay for Salt-Inducible Kinases (SIKs)." SLAS Discov 22(10): 1193-1202.

Heikamp, K., F. Zuccotto, M. Kiczun, P. Ray and I. H. Gilbert (2017). "Exhaustive Sampling of the Fragment Space Associated to a Molecule Leading to the Generation of Conserved Fragments." Chem Biol Drug Des.

Hewitt, S. N., D. M. Dranow, B. G. Horst, J. A. Abendroth, B. Forte, I. Hallyburton, C. Jansen, B. Baragana, R. Choi, K. L. Rivas, M. A. Hulverson, M. Dumais, T. E. Edwards, D. D. Lorimer, A. H. Fairlamb, D. W. Gray, K. D. Read, A. M. Lehane, K. Kirk, P. J. Myler, A. Wernimont, C. Walpole, R. Stacy, L. K. Barrett, I. H. Gilbert and W. C. Van Voorhis (2017). "Biochemical and Structural Characterization of Selective Allosteric Inhibitors of the Plasmodium falciparum Drug Target, Prolyl-tRNA-synthetase." ACS Infect Dis 3(1): 34-44.

Hughes, S. J. and A. Ciulli (2017). "Molecular recognition of ternary complexes: a new dimension in the structure-guided design of chemical degraders." Essays Biochem 61(5): 505-516.

Ivanova, I. M., S. A. Nepogodiev, G. Saalbach, E. C. O'Neill, M. D. Urbaniak, M. A. Ferguson, S. S. Gurcha, G. S. Besra and R. A. Field (2017). "Fluorescent mannosides serve as acceptor substrates for glycosyltransferase and sugar-1-phosphate transferase activities in Euglena gracilis membranes." Carbohydr Res 438: 26-38.

Jeacock, L., N. Baker, N. Wiedemar, P. Maser and D. Horn (2017). "Aquaglyceroporin-null trypanosomes display glycerol transport defects and respiratory-inhibitor sensitivity." PLoS Pathog 13(3): e1006307.

Jinnelov, A. A. J., L. Ali, M. Tinti and M. A. J. Ferguson (2017). "Single-subunit oligosaccharyltransferases of Trypanosoma brucei display different and predictable peptide acceptor specificities." J Biol Chem.

Kennedy, E. A., J. Connolly, J. O. Hourihane, P. G. Fallon, W. H. McLean, D. Murray, J. H. Jo, J. A. Segre, H. H. Kong and A. D. Irvine (2017). "Skin microbiome before development of atopic dermatitis: Early colonization with commensal staphylococci at 2 months is associated with a lower risk of atopic dermatitis at 1 year." J Allergy Clin Immunol 139(1): 166-172.

Lee, J. Y. W., C. K. Hsu, M. Michael, A. Nanda, L. Liu, J. R. McMillan, C. Pourreyron, T. Takeichi, J. Tolar, E. Reid, T. Hayday, S. C. Blumen, S. Abu-Mouch, R. Straussberg, L. Basel-Vanagaite, Y. Barhum, Y. Zouabi, H. Al-Ajmi, H. Y. Huang, T. C. Lin, M. Akiyama, J. Y. Y. Lee, W. H. I. McLean, M. A. Simpson, M. Parsons and J. A. McGrath (2017). "Large Intragenic Deletion in DSTYK Underlies Autosomal-Recessive Complicated Spastic Paraparesis, SPG23." Am J Hum Genet 100(2): 364-370.

Linciano, P., A. Dawson, I. Pohner, D. M. Costa, M. S. Sa, A. Cordeiro-da-Silva, R. Luciani, S. Gul, G. Witt, B. Ellinger, M. Kuzikov, P. Gribbon, J. Reinshagen, M. Wolf, B. Behrens, V. Hannaert, P. A. M. Michels, E. Nerini, C. Pozzi, F. di Pisa, G. Landi, N. Santarem, S. Ferrari, P. Saxena, S. Lazzari, G. Cannazza, L. H. Freitas-Junior, C. B. Moraes, B. S. Pascoalino, L. M. Alcantara, C. P. Bertolacini, V. Fontana, U. Wittig, W. Muller, R. C. Wade, W. N. Hunter, S. Mangani, L. Costantino and M. P. Costi (2017). "Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery." ACS Omega 2(9): 5666-5683.

Lucas, X. and A. Ciulli (2017). "Recognition of substrate degrons by E3 ubiquitin ligases and modulation by small-molecule mimicry strategies." Curr Opin Struct Biol 44: 101-110.

Macedo, J. P., R. B. Currier, C. Wirdnam, D. Horn, S. Alsford and D. Rentsch (2017). "Ornithine uptake and the modulation of drug sensitivity in Trypanosoma brucei." FASEB J 31(10): 4649-4660.

Maniaci, C., S. J. Hughes, A. Testa, W. Chen, D. J. Lamont, S. Rocha, D. R. Alessi, R. Romeo and A. Ciulli (2017). "Homo-PROTACs: bivalent small-molecule dimerizers of the VHL E3 ubiquitin ligase to induce self-degradation." Nat Commun 8(1): 830.

Manna, P. T., S. O. Obado, C. Boehm, C. Gadelha, A. Sali, B. T. Chait, M. P. Rout and M. C. Field (2017). "Lineage-specific proteins essential for endocytosis in trypanosomes." J Cell Sci 130(8): 1379-1392.

Martins da Silva, S. J., S. G. Brown, K. Sutton, L. V. King, H. Ruso, D. W. Gray, P. G. Wyatt, M. C. Kelly, C. L. R. Barratt and A. G. Hope (2017). "Drug discovery for male subfertility using high-throughput screening: a new approach to an unsolved problem." Hum Reprod 32(5): 974-984.

Meredith, E. L., A. Kumar, A. Konno, J. Szular, S. Alsford, K. Seifert, D. Horn and S. R. Wilkinson (2017). "Distinct activation mechanisms trigger the trypanocidal activity of DNA damaging prodrugs." Mol Microbiol 106(2): 207-222.

Morreale, F. E., A. Bortoluzzi, V. K. Chaugule, C. Arkinson, H. Walden and A. Ciulli (2017). "Allosteric Targeting of the Fanconi Anemia Ubiquitin-Conjugating Enzyme Ube2T by Fragment Screening." J Med Chem 60(9): 4093-4098.

Morreale, F. E., A. Testa, V. K. Chaugule, A. Bortoluzzi, A. Ciulli and H. Walden (2017). "Mind the Metal: A Fragment Library-Derived Zinc Impurity Binds the E2 Ubiquitin-Conjugating Enzyme Ube2T and Induces Structural Rearrangements." J Med Chem 60(19): 8183-8191.

Obado, S. O., M. C. Field and M. P. Rout (2017). "Comparative interactomics provides evidence for functional specialization of the nuclear pore complex." Nucleus: 1-13.

Ohguchi, Y., T. Nomura, S. Suzuki, M. Takeda, T. Miyauchi, O. Mizuno, S. Shinkuma, Y. Fujita, O. Nemoto, K. Ono, W. H. I. McLean and H. Shimizu (2017). "Gentamicin-induced readthrough and nonsense-mediated mRNA decay of SERPINB7 nonsense mutant transcripts." J Invest Dermatol.

Oliveira de Souza, J., A. Dawson and W. N. Hunter (2017). "An Improved Model of the Trypanosoma brucei CTP Synthetase Glutaminase Domain-Acivicin Complex." ChemMedChem 12(8): 577-579.

Park, Y., A. Pacitto, T. Bayliss, L. A. Cleghorn, Z. Wang, T. Hartman, K. Arora, T. R. Ioerger, J. Sacchettini, M. Rizzi, S. Donini, T. L. Blundell, D. B. Ascher, K. Rhee, A. Breda, N. Zhou, V. Dartois, S. R. Jonnala, L. E. Via, V. Mizrahi, O. Epemolu, L. Stojanovski, F. Simeons, M. Osuna-Cabello, L. Ellis, C. J. MacKenzie, A. R. Smith, S. H. Davis, D. Murugesan, K. I. Buchanan, P. A. Turner, M. Huggett, F. Zuccotto, M. J. Rebollo-Lopez, M. J. Lafuente-Monasterio, O. Sanz, G. S. Diaz, J. Lelievre, L. Ballell, C. Selenski, M. Axtman, S. Ghidelli-Disse, H. Pflaumer, M. Bosche, G. Drewes, G. M. Freiberg, M. D. Kurnick, M. Srikumaran, D. J. Kempf, S. R. Green, P. C. Ray, K. Read, P. Wyatt, C. E. Barry, 3rd and H. I. Boshoff (2017). "Essential but Not Vulnerable: Indazole Sulfonamides Targeting Inosine Monophosphate Dehydrogenase as Potential Leads against Mycobacterium tuberculosis." ACS Infect Dis 3(1): 18-33.

Pena-Diaz, P., M. Vancova, C. Resl, M. C. Field and J. Lukes (2017). "A leucine aminopeptidase is involved in kinetoplast DNA segregation in Trypanosoma brucei." PLoS Pathog 13(4): e1006310.

Ray, P. C., M. Kiczun, M. Huggett, A. Lim, F. Prati, I. H. Gilbert and P. G. Wyatt (2017). "Fragment library design, synthesis and expansion: nurturing a synthesis and training platform." Drug Discov Today 22(1): 43-56.

Rico, E., A. Ivens, L. Glover, D. Horn and K. R. Matthews (2017). "Genome-wide RNAi selection identifies a regulator of transmission stage-enriched gene families and cell-type differentiation in Trypanosoma brucei." PLoS Pathog 13(3): e1006279.

Rout, M. P. and M. C. Field (2017). "The Evolution of Organellar Coat Complexes and Organization of the Eukaryotic Cell." Annu Rev Biochem.

Rout, M. P., S. O. Obado, S. Schenkman and M. C. Field (2017). "Specialising the parasite nucleus: Pores, lamins, chromatin, and diversity." PLoS Pathog 13(3): e1006170.

Ryan, A., E. Polycarpou, N. A. Lack, D. Evangelopoulos, C. Sieg, A. Halman, S. Bhakta, O. Eleftheriadou, T. D. McHugh, S. Keany, E. D. Lowe, R. Ballet, A. Abuhammad, W. R. Jacobs, Jr., A. Ciulli and E. Sim (2017). "Investigation of the mycobacterial enzyme HsaD as a potential novel target for anti-tubercular agents using a fragment-based drug design approach." Br J Pharmacol.

Sekiya, A., M. Kono, H. Tsujiuchi, T. Kobayashi, T. Nomura, M. Kitakawa, N. Suzuki, K. Yamanaka, H. Sueki, W. H. McLean, H. Shimizu and M. Akiyama (2017). "Compound heterozygotes for filaggrin gene mutations do not always show severe atopic dermatitis." J Eur Acad Dermatol Venereol 31(1): 158-162.

Smith, F. J. D. and W. H. I. McLean (2017). "Keratin 6b variant p.Gly499Ser reported in delayed-onset pachyonychia congenita is a non-pathogenic polymorphism." J Dermatol.

Soares, P., M. S. Gadd, J. Frost, C. Galdeano, L. Ellis, O. Epemolu, S. Rocha, K. D. Read and A. Ciulli (2017). "Group-Based Optimization of Potent and Cell-Active Inhibitors of the von Hippel-Lindau (VHL) E3 Ubiquitin Ligase: Structure-Activity Relationships Leading to the Chemical Probe (2S,4R)-1-((S)-2-(1-Cyanocyclopropanecarboxamido)-3,3-dimethylbutanoyl)-4-hydroxy -N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide (VH298)." J Med Chem.

Stortz, J. A., T. D. Serafim, S. Alsford, J. Wilkes, F. Fernandez-Cortes, G. Hamilton, E. Briggs, L. Lemgruber, D. Horn, J. C. Mottram and R. McCulloch (2017). "Genome-wide and protein kinase-focused RNAi screens reveal conserved and novel damage response pathways in Trypanosoma brucei." PLoS Pathog 13(7): e1006477.

Takeichi, T., A. Torrelo, J. Y. W. Lee, Y. Ohno, M. L. Lozano, A. Kihara, L. Liu, Y. Yasuda, J. Ishikawa, T. Murase, A. B. Rodrigo, P. Fernandez-Crehuet, Y. Toi, J. Mellerio, J. Rivera, V. Vicente, D. P. Kelsell, Y. Nishimura, Y. Okuno, D. Kojima, Y. Ogawa, K. Sugiura, M. A. Simpson, W. H. I. McLean, M. Akiyama and J. A. McGrath (2017). "Biallelic Mutations in KDSR Disrupt Ceramide Synthesis and Result in a Spectrum of Keratinization Disorders Associated with Thrombocytopenia." J Invest Dermatol 137(11): 2344-2353.

Torrie, L. S., S. Brand, D. A. Robinson, E. J. Ko, L. Stojanovski, F. R. C. Simeons, S. Wyllie, J. Thomas, L. Ellis, M. Osuna-Cabello, O. Epemolu, A. Nuhs, J. Riley, L. MacLean, S. Manthri, K. D. Read, I. H. Gilbert, A. H. Fairlamb and M. De Rycker (2017). "Chemical Validation of Methionyl-tRNA Synthetase as a Druggable Target in Leishmania donovani." ACS Infect Dis 3(10): 718-727.

van Steensel, M. A. (2017). "Do shoot the messenger: Taking aim at RNA to treat genetic skin disorders." Exp Dermatol 26(1): 22-23.

van Steensel, M. A. (2017). "On the TRAIL to truth, or on a road to nowhere?" Exp Dermatol 26(3): 225-226.

Venkatesh, D., C. Boehm, L. D. Barlow, N. N. Nankissoor, A. O'Reilly, S. Kelly, J. B. Dacks and M. C. Field (2017). "Evolution of the endomembrane systems of trypanosomatids - conservation and specialisation." J Cell Sci 130(8): 1421-1434.

Volker-Touw, C. M., H. D. de Koning, J. C. Giltay, C. G. de Kovel, T. S. van Kempen, K. M. Oberndorff, M. L. Boes, M. A. van Steensel, G. T. van Well, W. A. Blokx, J. Schalkwijk, A. Simon, J. Frenkel and M. E. van Gijn (2017). "Erythematous nodes, urticarial rash and arthralgias in a large pedigree with NLRC4-related autoinflammatory disease, expansion of the phenotype." Br J Dermatol 176(1): 244-248.

Wilson, N. J., C. Cole, K. Kroboth, W. N. Hunter, J. A. Mann, W. H. McLean, K. Kernland Lang, H. Beltraminelli, R. A. Sabroe, N. Tiffin, G. J. Sobey, L. Borradori, E. Simpson and F. J. Smith (2017). "Mutations in POGLUT1 in Galli-Galli/Dowling-Degos disease." Br J Dermatol 176(1): 270-274.

Wong, X., S. Denil, J. N. Foo, H. Chen, A. S. L. Tay, R. L. Haines, M. B. Y. Tang, W. H. I. McLean, A. Sandilands, F. J. D. Smith, E. B. Lane, J. Liu and J. E. A. Common (2017). "Array-based sequencing of filaggrin gene for comprehensive detection of disease-associated variants." J Allergy Clin Immunol.

Zeeuwen, P. L., T. H. Ederveen, D. A. van der Krieken, H. Niehues, J. Boekhorst, S. Kezic, D. A. Hanssen, M. E. Otero, I. M. van Vlijmen-Willems, D. Rodijk-Olthuis, D. Falcone, E. H. van den Bogaard, M. Kamsteeg, H. D. de Koning, M. E. Zeeuwen-Franssen, M. A. van Steensel, M. Kleerebezem, H. M. Timmerman, S. A. van Hijum and J. Schalkwijk (2017). "Gram-positive anaerobe cocci are underrepresented in the microbiome of filaggrin-deficient human skin." J Allergy Clin Immunol 139(4): 1368-1371.