University of Dundee

Biological Chemistry and Drug Discovery 2015

Abbas, M., Schwartz, M. E., Smith, F. J., McLean, W. H. and Hull, P. R. (2015) PCQoL: A Quality of Life Assessment Measure for Pachyonychia Congenita. Journal of cutaneous medicine and surgery. 19, 57-65
doi; 10.2310/7750.2014.14017
PMC25775665

Aristotelous, T., Hopkins, A. L. and Navratilova, I. (2015) Surface plasmon resonance analysis of seven-transmembrane receptors. Methods in enzymology. 556, 499-525
doi; 10.1016/bs.mie.2015.01.016
PMC25857797

Baker, N., Hamilton, G., Wilkes, J. M., Hutchinson, S., Barrett, M. P. and Horn, D. (2015) Vacuolar ATPase depletion affects mitochondrial ATPase function, kinetoplast dependency, and drug sensitivity in trypanosomes. Proceedings of the National Academy of Sciences of the United States of America. 112, 9112-9117
doi; 10.1073/pnas.1505411112
PMID;4517229  PMC26150481

Baragana, B., Hallyburton, I., Lee, M. C., Norcross, N. R., Grimaldi, R., Otto, T. D., Proto, W. R., Blagborough, A. M., Meister, S., Wirjanata, G., Ruecker, A., Upton, L. M., Abraham, T. S., Almeida, M. J., Pradhan, A., Porzelle, A., Martinez, M. S., Bolscher, J. M., Woodland, A., Norval, S., Zuccotto, F., Thomas, J., Simeons, F., Stojanovski, L., Osuna-Cabello, M., Brock, P. M., Churcher, T. S., Sala, K. A., Zakutansky, S. E., Jimenez-Diaz, M. B., Sanz, L. M., Riley, J., Basak, R., Campbell, M., Avery, V. M., Sauerwein, R. W., Dechering, K. J., Noviyanti, R., Campo, B., Frearson, J. A., Angulo-Barturen, I., Ferrer-Bazaga, S., Gamo, F. J., Wyatt, P. G., Leroy, D., Siegl, P., Delves, M. J., Kyle, D. E., Wittlin, S., Marfurt, J., Price, R. N., Sinden, R. E., Winzeler, E. A., Charman, S. A., Bebrevska, L., Gray, D. W., Campbell, S., Fairlamb, A. H., Willis, P. A., Rayner, J. C., Fidock, D. A., Read, K. D. and Gilbert, I. H. (2015) A novel multiple-stage antimalarial agent that inhibits protein synthesis. Nature. 522, 315-320
doi; 10.1038/nature14451
PMC26085270

Barrack, K. L., Fyfe, P. K., Finney, A. J. and Hunter, W. N. (2015) Crystal structure of the C-terminal domain of tubulin-binding cofactor C from Leishmania major. Molecular and biochemical parasitology. 201, 26-30
doi; 10.1016/j.molbiopara.2015.05.003
PMID;4539340  PMC25982270

Barrack, K. L., Fyfe, P. K. and Hunter, W. N. (2015) The structure of tubulin-binding cofactor A from Leishmania major infers a mode of association during the early stages of microtubule assembly. Acta crystallographica. Section F, Structural biology communications. 71, 539-546
doi; 10.1107/S2053230X15000990
PMID;4427162  PMC25945706

Bart, J. M., Cordon-Obras, C., Vidal, I., Reed, J., Perez-Pastrana, E., Cuevas, L., Field, M. C., Carrington, M. and Navarro, M. (2015) Localization of serum resistance-associated protein in Trypanosoma brucei rhodesiense and transgenic Trypanosoma brucei brucei. Cellular microbiology. 17, 1523-1535
doi; 10.1111/cmi.12454
PMC25924022

Baud, M. G., Lin-Shiao, E., Zengerle, M., Tallant, C. and Ciulli, A. (2015) New Synthetic Routes to Triazolo-benzodiazepine Analogues: Expanding the Scope of the Bump-and-Hole Approach for Selective Bromo and Extra-Terminal (BET) Bromodomain Inhibition. Journal of medicinal chemistrydoi; 10.1021/acs.jmedchem.5b01135
PMC26367539

Baum, B., Lecker, L. S., Zoltner, M., Jaenicke, E., Schnell, R., Hunter, W. N. and Brenk, R. (2015) Structures of Pseudomonas aeruginosa beta-ketoacyl-(acyl-carrier-protein) synthase II (FabF) and a C164Q mutant provide templates for antibacterial drug discovery and identify a buried potassium ion and a ligand-binding site that is an artefact of the crystal form. Acta crystallographica. Section F, Structural biology communications. 71, 1020-1026
doi; 10.1107/S2053230X15010614
PMID;4528935  PMC26249693

Baurecht, H., Hotze, M., Brand, S., Buning, C., Cormican, P., Corvin, A., Ellinghaus, D., Ellinghaus, E., Esparza-Gordillo, J., Folster-Holst, R., Franke, A., Gieger, C., Hubner, N., Illig, T., Irvine, A. D., Kabesch, M., Lee, Y. A., Lieb, W., Marenholz, I., McLean, W. H., Morris, D. W., Mrowietz, U., Nair, R., Nothen, M. M., Novak, N., O'Regan, G. M., Consortium, P., Schreiber, S., Smith, C., Strauch, K., Stuart, P. E., Trembath, R., Tsoi, L. C., Weichenthal, M., Barker, J., Elder, J. T., Weidinger, S., Cordell, H. J. and Brown, S. J. (2015) Genome-wide comparative analysis of atopic dermatitis and psoriasis gives insight into opposing genetic mechanisms. American journal of human genetics. 96, 104-120
doi; 10.1016/j.ajhg.2014.12.004
PMID;4289690  PMC25574825

Besnard, J., Jones, P. S., Hopkins, A. L. and Pannifer, A. D. (2015) The Joint European Compound Library: boosting precompetitive research. Drug discovery today. 20, 181-186
doi; 10.1016/j.drudis.2014.08.014
PMC25205347

Bulatov, E. and Ciulli, A. (2015) Targeting Cullin-RING E3 ubiquitin ligases for drug discovery: structure, assembly and small-molecule modulation. The Biochemical journal. 467, 365-386
doi; 10.1042/BJ20141450
PMID;4403949  PMC25886174

Bulatov, E., Martin, E. M., Chatterjee, S., Knebel, A., Shimamura, S., Konijnenberg, A., Johnson, C., Zinn, N., Grandi, P., Sobott, F. and Ciulli, A. (2015) Biophysical studies on interactions and assembly of full-size E3 ubiquitin ligase: suppressor of cytokine signaling 2 (SOCS2)-elongin BC-cullin 5-ring box protein 2 (RBX2). The Journal of biological chemistry. 290, 4178-4191
doi; 10.1074/jbc.M114.616664
PMID;4326827  PMC25505247

Cardote, T. A. and Ciulli, A. (2015) Cyclic and Macrocyclic Peptides as Chemical Tools To Recognise Protein Surfaces and Probe Protein-Protein Interactions. ChemMedChem
doi; 10.1002/cmdc.201500450
PMC26563831

Cleghorn, L. A., Albrecht, S., Stojanovski, L., Simeons, F. R., Norval, S., Kime, R., Collie, I. T., De Rycker, M., Campbell, L., Hallyburton, I., Frearson, J. A., Wyatt, P. G., Read, K. D. and Gilbert, I. H. (2015) Discovery of Indoline-2-carboxamide Derivatives as a New Class of Brain-Penetrant Inhibitors of Trypanosoma brucei. Journal of medicinal chemistry. 58, 7695-7706
doi; 10.1021/acs.jmedchem.5b00596
PMID;4601051  PMC26418485

Courtney, D. G., Moore, J. E., Atkinson, S. D., Maurizi, E., Allen, E. H., Pedrioli, D. M., McLean, W. H., Nesbit, M. A. and Moore, C. B. (2015) CRISPR/Cas9 DNA cleavage at SNP-derived PAM enables both in vitro and in vivo KRT12 mutation-specific targeting. Gene therapydoi; 10.1038/gt.2015.82
PMC26289666

Damerow, S., Hoppe, C., Bandini, G., Zarnovican, P., Buettner, F. F., Ferguson, M. A. and Routier, F. H. (2015) Leishmania major UDP-sugar pyrophosphorylase salvages galactose for glycoconjugate biosynthesis. International journal for parasitology. 45, 783-790
doi; 10.1016/j.ijpara.2015.06.004
PMC26215058

Damerow, S., Hoppe, C., Bandini, G., Zarnovican, P., Buettner, F. R., Luder, C. G., Ferguson, M. A. and Routier, F. H. (2015) Depletion of UDP-Glucose and UDP-Galactose Using a Degron System Leads to Growth Cessation of Leishmania major. PLoS neglected tropical diseases. 9, e0004205
doi; 10.1371/journal.pntd.0004205
PMID;4631452  PMC26529232

Dias, D. M., Furtado, J., Wasielewski, E., Cruz, R., Costello, B., Cole, L., Faria, T. Q., Baaske, P., Brito, R. M., Ciulli, A., Simoes, I., MacEdo-Ribeiro, S., Faro, C., Geraldes, C. F. and Castanheira, P. (2015) Biophysical characterization of laforin-carbohydrate interaction. The Biochemical journaldoi; 10.1042/BJ20141555
PMC26578817

Domingo-Sananes, M. R., Szoor, B., Ferguson, M. A., Urbaniak, M. D. and Matthews, K. R. (2015) Molecular control of irreversible bistability during trypanosome developmental commitment. The Journal of cell biology. 211, 455-468
doi; 10.1083/jcb.201506114
PMID;4621835  PMC26483558

Eadsforth, T. C., Pinto, A., Luciani, R., Tamborini, L., Cullia, G., De Micheli, C., Marinelli, L., Cosconati, S., Novellino, E., Lo Presti, L., Cordeiro da Silva, A., Conti, P., Hunter, W. N. and Costi, M. P. (2015) Characterization of 2,4-Diamino-6-oxo-1,6-dihydropyrimidin-5-yl Ureido Based Inhibitors of Trypanosoma brucei FolD and Testing for Antiparasitic Activity. Journal of medicinal chemistry. 58, 7938-7948
doi; 10.1021/acs.jmedchem.5b00687
PMID;4621507  PMC26322631

Fang, W., Robinson, D. A., Raimi, O. G., Blair, D. E., Harrison, J. R., Lockhart, D. E., Torrie, L. S., Ruda, G. F., Wyatt, P. G., Gilbert, I. H. and van Aalten, D. M. (2015) N-myristoyltransferase is a cell wall target in Aspergillus fumigatus. ACS chemical biology. 10, 1425-1434
doi; 10.1021/cb5008647
PMID;4477619  PMC25706802

Gadd, M. S., Bulatov, E. and Ciulli, A. (2015) Serendipitous SAD Solution for DMSO-Soaked SOCS2-ElonginC-ElonginB Crystals Using Covalently Incorporated Dimethylarsenic: Insights into Substrate Receptor Conformational Flexibility in Cullin RING Ligases. PloS one. 10, e0131218
doi; 10.1371/journal.pone.0131218
PMID;4486172  PMC26121586

Gadelha, C., Zhang, W., Chamberlain, J. W., Chait, B. T., Wickstead, B. and Field, M. C. (2015) Architecture of a Host-Parasite Interface: Complex Targeting Mechanisms Revealed Through Proteomics. Molecular & cellular proteomics : MCP. 14, 1911-1926
doi; 10.1074/mcp.M114.047647
PMID;4587319  PMC25931509

Glover, L., Alsford, S., Baker, N., Turner, D. J., Sanchez-Flores, A., Hutchinson, S., Hertz-Fowler, C., Berriman, M. and Horn, D. (2015) Genome-scale RNAi screens for high-throughput phenotyping in bloodstream-form African trypanosomes. Nature protocols. 10, 106-133
doi; 10.1038/nprot.2015.005
PMC25502887

Graf, F. E., Baker, N., Munday, J. C., de Koning, H. P., Horn, D. and Maser, P. (2015) Chimerization at the AQP2-AQP3 locus is the genetic basis of melarsoprol-pentamidine cross-resistance in clinical Trypanosoma brucei gambiense isolates. International journal for parasitology. Drugs and drug resistance. 5, 65-68
doi; 10.1016/j.ijpddr.2015.04.002
PMID;4443405  PMC26042196

Guidi, A., Mansour, N. R., Paveley, R. A., Carruthers, I. M., Besnard, J., Hopkins, A. L., Gilbert, I. H. and Bickle, Q. D. (2015) Application of RNAi to Genomic Drug Target Validation in Schistosomes. PLoS neglected tropical diseases. 9, e0003801
doi; 10.1371/journal.pntd.0003801
PMID;4438872  PMC25992548

Hung, A. W., Silvestre, H. L., Wen, S., George, G. P., Boland, J., Blundell, T. L., Ciulli, A. and Abell, C. (2015) Optimization of Inhibitors of Mycobacterium tuberculosis Pantothenate Synthetase Based on Group Efficiency Analysis. ChemMedChemdoi; 10.1002/cmdc.201500414
PMC26486566

Hunter, W. N. and Weiss, M. S. (2015) Macromolecular crystallography and what it can contribute to antiparasite drug discovery. Acta crystallographica. Section F, Structural biology communications. 71, 483-484
doi; 10.1107/S2053230X1500789X
PMID;4427156  PMC25945700

Izquierdo, L., Acosta-Serrano, A., Mehlert, A. and Ferguson, M. A. (2015) Identification of a glycosylphosphatidylinositol anchor-modifying beta1-3 galactosyltransferase in Trypanosoma brucei. Glycobiology. 25, 438-447
doi; 10.1093/glycob/cwu131
PMID;4339879  PMC25467966

Kelleher, M., Dunn-Galvin, A., Hourihane, J. O., Murray, D., Campbell, L. E., McLean, W. H. and Irvine, A. D. (2015) Skin barrier dysfunction measured by transepidermal water loss at 2 days and 2 months predates and predicts atopic dermatitis at 1 year. The Journal of allergy and clinical immunology. 135, 930-935 e931
doi; 10.1016/j.jaci.2014.12.013
PMID;4382348  PMC25618747

Lin, Z., Zhao, J., Nitoiu, D., Scott, C. A., Plagnol, V., Smith, F. J., Wilson, N. J., Cole, C., Schwartz, M. E., McLean, W. H., Wang, H., Feng, C., Duo, L., Zhou, E. Y., Ren, Y., Dai, L., Chen, Y., Zhang, J., Xu, X., O'Toole, E. A., Kelsell, D. P. and Yang, Y. (2015) Loss-of-function mutations in CAST cause peeling skin, leukonychia, acral punctate keratoses, cheilitis, and knuckle pads. American journal of human genetics. 96, 440-447
doi; 10.1016/j.ajhg.2014.12.026
PMID;4375526  PMC25683118

Ludewig, M. H., Boshoff, A., Horn, D. and Blatch, G. L. (2015) Trypanosoma brucei J protein 2 is a stress inducible and essential Hsp40. The international journal of biochemistry & cell biology. 60, 93-98
doi; 10.1016/j.biocel.2014.12.016
PMC25562516

Manna, P. T., Gadelha, C., Puttick, A. E. and Field, M. C. (2015) ENTH and ANTH domain proteins participate in AP2-independent clathrin-mediated endocytosis. Journal of cell science. 128, 2130-2142
doi; 10.1242/jcs.167726
PMID;4450294  PMC25908855

McAleer, M. A., Pohler, E., Smith, F. J., Wilson, N. J., Cole, C., MacGowan, S., Koetsier, J. L., Godsel, L. M., Harmon, R. M., Gruber, R., Crumrine, D., Elias, P. M., McDermott, M., Butler, K., Broderick, A., Sarig, O., Sprecher, E., Green, K. J., McLean, W. H. and Irvine, A. D. (2015) Severe dermatitis, multiple allergies, and metabolic wasting syndrome caused by a novel mutation in the N-terminal plakin domain of desmoplakin. The Journal of allergy and clinical immunology. 136, 1268-1276
doi; 10.1016/j.jaci.2015.05.002
PMC26073755

McCulloch, R. and Field, M. C. (2015) Quantitative sequencing confirms VSG diversity as central to immune evasion by Trypanosoma brucei. Trends in parasitology. 31, 346-349
doi; 10.1016/j.pt.2015.05.001
PMC25999027

Mital, A., Murugesan, D., Kaiser, M., Yeates, C. and Gilbert, I. H. (2015) Discovery and optimisation studies of antimalarial phenotypic hits. European journal of medicinal chemistry. 103, 530-538
doi; 10.1016/j.ejmech.2015.08.044
PMID;4607724  PMC26408453

Moynie, L., Hope, A. G., Finzel, K., Schmidberger, J., Leckie, S. M., Schneider, G., Burkart, M. D., Smith, A. D., Gray, D. W. and Naismith, J. H. (2015) A Substrate Mimic Allows High-Throughput Assay of the FabA Protein and Consequently the Identification of a Novel Inhibitor of Pseudomonas aeruginosa FabA. Journal of molecular biologydoi; 10.1016/j.jmb.2015.10.027
PMC26562505

Nuhs, A., De Rycker, M., Manthri, S., Comer, E., Scherer, C. A., Schreiber, S. L., Ioset, J. R. and Gray, D. W. (2015) Development and Validation of a Novel Leishmania donovani Screening Cascade for High-Throughput Screening Using a Novel Axenic Assay with High Predictivity of Leishmanicidal Intracellular Activity. PLoS neglected tropical diseases. 9, e0004094
doi; 10.1371/journal.pntd.0004094
PMID;4583543  PMC26407168

Ong, H. B., Lee, W. S., Patterson, S., Wyllie, S. and Fairlamb, A. H. (2015) Homoserine and quorum-sensing acyl homoserine lactones as alternative sources of threonine: a potential role for homoserine kinase in insect-stage Trypanosoma brucei. Molecular microbiology. 95, 143-156
doi; 10.1111/mmi.12853
PMID;4460637  PMC25367138

Pena, I., Pilar Manzano, M., Cantizani, J., Kessler, A., Alonso-Padilla, J., Bardera, A. I., Alvarez, E., Colmenarejo, G., Cotillo, I., Roquero, I., de Dios-Anton, F., Barroso, V., Rodriguez, A., Gray, D. W., Navarro, M., Kumar, V., Sherstnev, A., Drewry, D. H., Brown, J. R., Fiandor, J. M. and Julio Martin, J. (2015) New compound sets identified from high throughput phenotypic screening against three kinetoplastid parasites: an open resource. Scientific reports. 5, 8771
doi; 10.1038/srep08771
PMID;4350103  PMC25740547

Perry, M. R., Prajapati, V. K., Menten, J., Raab, A., Feldmann, J., Chakraborti, D., Sundar, S., Fairlamb, A. H., Boelaert, M. and Picado, A. (2015) Arsenic exposure and outcomes of antimonial treatment in visceral leishmaniasis patients in Bihar, India: a retrospective cohort study. PLoS neglected tropical diseases. 9, e0003518
doi; 10.1371/journal.pntd.0003518
PMID;4346263  PMC25730310

Pohler, E., Cunningham, F., Sandilands, A., Cole, C., Digby, S., McMillan, J. R., Aristodemou, S., McGrath, J. A., Smith, F. J., McLean, W. H., Munro, C. S. and Zamiri, M. (2015) Novel autosomal dominant mutation in loricrin presenting as prominent ichthyosis. The British journal of dermatologydoi; 10.1111/bjd.13895
PMC25965869

Possik, E., Ajisebutu, A., Manteghi, S., Gingras, M. C., Vijayaraghavan, T., Flamand, M., Coull, B., Schmeisser, K., Duchaine, T., van Steensel, M., Hall, D. H. and Pause, A. (2015) FLCN and AMPK Confer Resistance to Hyperosmotic Stress via Remodeling of Glycogen Stores. PLoS genetics. 11, e1005520
doi; 10.1371/journal.pgen.1005520
PMID;4595296  PMC26439621

Riethmuller, C., McAleer, M. A., Koppes, S. A., Abdayem, R., Franz, J., Haftek, M., Campbell, L. E., MacCallum, S. F., McLean, W. H., Irvine, A. D. and Kezic, S. (2015) Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis. The Journal of allergy and clinical immunologydoi; 10.1016/j.jaci.2015.04.042
PMC26071937

Riley, J., Brand, S., Voice, M., Caballero, I., Calvo, D. and Read, K. D. (2015) Development of a Fluorescence-based Trypanosoma cruzi CYP51 Inhibition Assay for Effective Compound Triaging in Drug Discovery Programmes for Chagas Disease. PLoS neglected tropical diseases. 9, e0004014
doi; 10.1371/journal.pntd.0004014
PMID;4578769  PMC26394211

Robinson, D. A. and Wyatt, P. G. (2015) Identification and structure solution of fragment hits against kinetoplastid N-myristoyltransferase. Acta crystallographica. Section F, Structural biology communications. 71, 586-593
doi; 10.1107/S2053230X15003040
PMID;4427169  PMC25945713

Rodrigues, J. A., Acosta-Serrano, A., Aebi, M., Ferguson, M. A., Routier, F. H., Schiller, I., Soares, S., Spencer, D., Titz, A., Wilson, I. B. and Izquierdo, L. (2015) Parasite Glycobiology: A Bittersweet Symphony. PLoS pathogens. 11, e1005169
doi; 10.1371/journal.ppat.1005169
PMID;4642930  PMC26562305

Schmitt, J., Schwarz, K., Baurecht, H., Hotze, M., Folster-Holst, R., Rodriguez, E., Lee, Y. A., Franke, A., Degenhardt, F., Lieb, W., Gieger, C., Kabesch, M., Nothen, M. M., Irvine, A. D., McLean, W. H., Deckert, S., Stephan, V., Schwarz, P., Aringer, M., Novak, N. and Weidinger, S. (2015) Atopic dermatitis is associated with an increased risk for rheumatoid arthritis and inflammatory bowel disease, and a decreased risk for type 1 diabetes. The Journal of allergy and clinical immunologydoi; 10.1016/j.jaci.2015.06.029
PMC26253344

Shameer, S., Logan-Klumpler, F. J., Vinson, F., Cottret, L., Merlet, B., Achcar, F., Boshart, M., Berriman, M., Breitling, R., Bringaud, F., Butikofer, P., Cattanach, A. M., Bannerman-Chukualim, B., Creek, D. J., Crouch, K., de Koning, H. P., Denise, H., Ebikeme, C., Fairlamb, A. H., Ferguson, M. A., Ginger, M. L., Hertz-Fowler, C., Kerkhoven, E. J., Maser, P., Michels, P. A., Nayak, A., Nes, D. W., Nolan, D. P., Olsen, C., Silva-Franco, F., Smith, T. K., Taylor, M. C., Tielens, A. G., Urbaniak, M. D., van Hellemond, J. J., Vincent, I. M., Wilkinson, S. R., Wyllie, S., Opperdoes, F. R., Barrett, M. P. and Jourdan, F. (2015) TrypanoCyc: a community-led biochemical pathways database for Trypanosoma brucei. Nucleic acids research. 43, D637-644
doi; 10.1093/nar/gku944
PMID;4384016  PMC25300491

Sola, I., Castella, S., Viayna, E., Galdeano, C., Taylor, M. C., Gbedema, S. Y., Perez, B., Clos, M. V., Jones, D. C., Fairlamb, A. H., Wright, C. W., Kelly, J. M. and Munoz-Torrero, D. (2015) Synthesis, biological profiling and mechanistic studies of 4-aminoquinoline-based heterodimeric compounds with dual trypanocidal-antiplasmodial activity. Bioorganic & medicinal chemistry. 23, 5156-5167
doi; 10.1016/j.bmc.2015.01.031
PMC25678015

Spinks, D., Smith, V., Thompson, S., Robinson, D. A., Luksch, T., Smith, A., Torrie, L. S., McElroy, S., Stojanovski, L., Norval, S., Collie, I. T., Hallyburton, I., Rao, B., Brand, S., Brenk, R., Frearson, J. A., Read, K. D., Wyatt, P. G. and Gilbert, I. H. (2015) Development of Small-Molecule Trypanosoma brucei N-Myristoyltransferase Inhibitors: Discovery and Optimisation of a Novel Binding Mode. ChemMedChem. 10, 1821-1836
doi; 10.1002/cmdc.201500301
PMID;4648043  PMC26395087

Tallant, C., Valentini, E., Fedorov, O., Overvoorde, L., Ferguson, F. M., Filippakopoulos, P., Svergun, D. I., Knapp, S. and Ciulli, A. (2015) Molecular basis of histone tail recognition by human TIP5 PHD finger and bromodomain of the chromatin remodeling complex NoRC. Structure. 23, 80-92
doi; 10.1016/j.str.2014.10.017
PMID;4291147  PMC25533489

Watt, S. A., Dayal, J. H., Wright, S., Riddle, M., Pourreyron, C., McMillan, J. R., Kimble, R. M., Prisco, M., Gartner, U., Warbrick, E., McLean, W. H., Leigh, I. M., McGrath, J. A., Salas-Alanis, J. C., Tolar, J. and South, A. P. (2015) Lysyl Hydroxylase 3 Localizes to Epidermal Basement Membrane and Is Reduced in Patients with Recessive Dystrophic Epidermolysis Bullosa. PloS one. 10, e0137639
doi; 10.1371/journal.pone.0137639
PMID;4575209  PMC26380979

Weiss, M. S. and Hunter, W. N. (2015) The power of three. Acta crystallographica. Section F, Structural biology communications. 71, 1453
doi; 10.1107/S2053230X15022050
PMC26625284

Wilson, N. J., Cole, C., Milstone, L. M., Kiszewski, A. E., Hansen, C. D., O'Toole, E. A., Schwartz, M. E., McLean, W. H. and Smith, F. J. (2015) Expanding the Phenotypic Spectrum of Olmsted Syndrome. The Journal of investigative dermatology. 135, 2879-2883
doi; 10.1038/jid.2015.217
PMID;4652067  PMC26067147

Woodland, A., Thompson, S., Cleghorn, L. A., Norcross, N., De Rycker, M., Grimaldi, R., Hallyburton, I., Rao, B., Norval, S., Stojanovski, L., Brun, R., Kaiser, M., Frearson, J. A., Gray, D. W., Wyatt, P. G., Read, K. D. and Gilbert, I. H. (2015) Discovery of Inhibitors of Trypanosoma brucei by Phenotypic Screening of a Focused Protein Kinase Library. ChemMedChem. 10, 1809-1820
doi; 10.1002/cmdc.201500300
PMID;4648050  PMC26381210

Wyllie, S., Foth, B. J., Kelner, A., Sokolova, A. Y., Berriman, M. and Fairlamb, A. H. (2015) Nitroheterocyclic drug resistance mechanisms in Trypanosoma brucei. The Journal of antimicrobial chemotherapydoi; 10.1093/jac/dkv376
PMC26581221

Zengerle, M., Chan, K. H. and Ciulli, A. (2015) Selective Small Molecule Induced Degradation of the BET Bromodomain Protein BRD4. ACS chemical biology. 10, 1770-1777
doi; 10.1021/acschembio.5b00216
PMID;4548256  PMC26035625

Zoltner, M., Leung, K. F., Alsford, S., Horn, D. and Field, M. C. (2015) Modulation of the Surface Proteome through Multiple Ubiquitylation Pathways in African Trypanosomes. PLoS pathogens. 11, e1005236
doi; 10.1371/journal.ppat.1005236
PMID;4619645  PMC26492041