University of Dundee

Biological Chemistry and Drug Discovery 2010

Anderson, J. S., Ferguson, M. A., Lopez-Larson, M. and Yurgelun-Todd, D. (2010) Topographic maps of multisensory attention. Proc Natl Acad Sci U S A. 107, 20110-20114
doi; 10.1073/pnas.1011616107
PMID;2993335  PMC21041658

Andrews, P. D., Becroft, M., Aspegren, A., Gilmour, J., James, M. J., McRae, S., Kime, R., Allcock, R. W., Abraham, A., Jiang, Z., Strehl, R., Mountford, J. C., Milligan, G., Houslay, M. D., Adams, D. R. and Frearson, J. A. (2010) High-content screening of feeder-free human embryonic stem cells to identify pro-survival small molecules. Biochem J. 432, 21-33
doi; 10.1042/BJ20101022

Arban, R., Bianchi, F., Buson, A., Cremonesi, S., Di Fabio, R., Gentile, G., Micheli, F., Pasquarello, A., Pozzan, A., Tarsi, L., Terreni, S. and Tonelli, F. (2010) Pyrrolo[1,2-a]pyrazine and pyrazolo[1,5-a]pyrazine: novel, potent, and selective series of Vasopressin 1b receptor antagonists. Bioorg Med Chem Lett. 20, 5044-5049
doi; 10.1016/j.bmcl.2010.07.037

Aschner, P., Katzeff, H. L., Guo, H., Sunga, S., Williams-Herman, D., Kaufman, K. D., Goldstein, B. J. and Sitagliptin Study, G. (2010) Efficacy and safety of monotherapy of sitagliptin compared with metformin in patients with type 2 diabetes. Diabetes Obes Metab. 12, 252-261
doi; 10.1111/j.1463-1326.2009.01187.x

Atrih, A., Turnock, D., Sellar, G., Thompson, A., Feuerstein, G., Ferguson, M. A. and Huang, J. T. (2010) Stoichiometric quantification of Akt phosphorylation using LC-MS/MS. J Proteome Res. 9, 743-751
doi; 10.1021/pr900572h
PMID;2816933  PMC19902931

Bhat, V. T., Caniard, A. M., Luksch, T., Brenk, R., Campopiano, D. J. and Greaney, M. F. (2010) Nucleophilic catalysis of acylhydrazone equilibration for protein-directed dynamic covalent chemistry. Nature chemistry. 2, 490-497
doi; 10.1038/nchem.658
PMID;2913121  PMC20489719

Cui, H., Ruda, G. F., Carrero-Lerida, J., Ruiz-Perez, L. M., Gilbert, I. H. and Gonzalez-Pacanowska, D. (2010) Exploring new inhibitors of Plasmodium falciparum purine nucleoside phosphorylase. Eur J Med Chem. 45, 5140-5149
doi; 10.1016/j.ejmech.2010.08.026

Cui, H., Ruiz-Perez, L. M., Gonzalez-Pacanowska, D. and Gilbert, I. H. (2010) Potential application of thymidylate kinase in nucleoside analogue activation in Plasmodium falciparum. Bioorg Med Chem. 18, 7302-7309
doi; 10.1016/j.bmc.2010.07.006

Dawson, A., Chen, M., Fyfe, P. K., Guo, Z. and Hunter, W. N. (2010) Structure and reactivity of Bacillus subtilis MenD catalyzing the first committed step in menaquinone biosynthesis. J Mol Biol. 401, 253-264
doi; 10.1016/j.jmb.2010.06.025
PMID;2914249  PMC20600129

Dawson, A., Tulloch, L. B., Barrack, K. L. and Hunter, W. N. (2010) High-resolution structures of Trypanosoma brucei pteridine reductase ligand complexes inform on the placement of new molecular entities in the active site of a potential drug target. Acta Crystallogr D Biol Crystallogr. 66, 1334-1340
doi; 10.1107/S0907444910040886
PMID;3655514  PMC21123874

Dorfmueller, H. C., Borodkin, V. S., Schimpl, M., Zheng, X., Kime, R., Read, K. D. and van Aalten, D. M. (2010) Cell-penetrant, nanomolar O-GlcNAcase inhibitors selective against lysosomal hexosaminidases. Chem Biol. 17, 1250-1255
doi; 10.1016/j.chembiol.2010.09.014
PMID;3032886  PMC21095575

Durrant, J. D., Amaro, R. E., Xie, L., Urbaniak, M. D., Ferguson, M. A., Haapalainen, A., Chen, Z., Di Guilmi, A. M., Wunder, F., Bourne, P. E. and McCammon, J. A. (2010) A multidimensional strategy to detect polypharmacological targets in the absence of structural and sequence homology. PLoS Comput Biol. 6, e1000648
doi; 10.1371/journal.pcbi.1000648
PMID;2799658  PMC20098496

Durrant, J. D., Urbaniak, M. D., Ferguson, M. A. and McCammon, J. A. (2010) Computer-aided identification of Trypanosoma brucei uridine diphosphate galactose 4'-epimerase inhibitors: toward the development of novel therapies for African sleeping sickness. J Med Chem. 53, 5025-5032
doi; 10.1021/jm100456a
PMID;2895357  PMC20527952

Ferguson, M. A., Needleman, M., Mitchell, E. S., Carter, L. I., Bustamante, A. I., Love, K. M. and Curran, M. J. (2010) A history of prior bare metal stent restenosis is associated with major adverse cardiac events in subsequent bare metal stenting of de novo coronary lesions. Cardiology. 116, 190-193
doi; 10.1159/000319472

Ferguson, M. A., Vaidya, V. S., Waikar, S. S., Collings, F. B., Sunderland, K. E., Gioules, C. J. and Bonventre, J. V. (2010) Urinary liver-type fatty acid-binding protein predicts adverse outcomes in acute kidney injury. Kidney Int. 77, 708-714
doi; 10.1038/ki.2009.422
PMID;2880954  PMC19940842

Field, M. C., Sergeenko, T., Wang, Y. N., Bohm, S. and Carrington, M. (2010) Chaperone requirements for biosynthesis of the trypanosome variant surface glycoprotein. PLoS One. 5, e8468
doi; 10.1371/journal.pone.0008468
PMID;2797082  PMC20052285

Flanagan, C. M., Kaesberg, J. L., Mitchell, E. S., Ferguson, M. A. and Haigney, M. C. (2010) Coronary artery aneurysm and thrombosis following chronic ephedra use. Int J Cardiol. 139, e11-13
doi; 10.1016/j.ijcard.2008.06.081

Fleming, J. R., Dawson, A. and Hunter, W. N. (2010) Crystal structure of Leishmania major ADP-ribosylation factor-like 1 and a classification of related GTPase family members in this Kinetoplastid. Mol Biochem Parasitol. 174, 141-144
doi; 10.1016/j.molbiopara.2010.08.002
PMID;3065712  PMC20801163

Frearson, J. and Wyatt, P. (2010) Drug Discovery in Academia- the third way? Expert Opin Drug Discov. 5, 909-919
doi; 10.1517/17460441.2010.506508
PMID;2948567  PMC20922062

Frearson, J. A., Brand, S., McElroy, S. P., Cleghorn, L. A., Smid, O., Stojanovski, L., Price, H. P., Guther, M. L., Torrie, L. S., Robinson, D. A., Hallyburton, I., Mpamhanga, C. P., Brannigan, J. A., Wilkinson, A. J., Hodgkinson, M., Hui, R., Qiu, W., Raimi, O. G., van Aalten, D. M., Brenk, R., Gilbert, I. H., Read, K. D., Fairlamb, A. H., Ferguson, M. A., Smith, D. F. and Wyatt, P. G. (2010) N-myristoyltransferase inhibitors as new leads to treat sleeping sickness. Nature. 464, 728-732
doi; 10.1038/nature08893
PMID;2917743  PMC20360736

Fyfe, P. K., Alphey, M. S. and Hunter, W. N. (2010) Structure of Trypanosoma brucei glutathione synthetase: domain and loop alterations in the catalytic cycle of a highly conserved enzyme. Mol Biochem Parasitol. 170, 93-99
doi; 10.1016/j.molbiopara.2009.12.011
PMID;2845819  PMC20045436

Fyfe, P. K., Dawson, A., Hutchison, M. T., Cameron, S. and Hunter, W. N. (2010) Structure of Staphylococcus aureus adenylosuccinate lyase (PurB) and assessment of its potential as a target for structure-based inhibitor discovery. Acta Crystallogr D Biol Crystallogr. 66, 881-888
doi; 10.1107/S0907444910020081
PMID;2917274  PMC20693687

Gigante, F., Kaiser, M., Brun, R. and Gilbert, I. H. (2010) Design and preparation of sterol mimetics as potential antiparasitics. Bioorg Med Chem. 18, 7291-7301
doi; 10.1016/j.bmc.2010.08.007

Jim, H. S., Small, B. J., Patterson, S., Salup, R. and Jacobsen, P. B. (2010) Cognitive impairment in men treated with luteinizing hormone-releasing hormone agonists for prostate cancer: a controlled comparison. Support Care Cancer. 18, 21-27
doi; 10.1007/s00520-009-0625-3

Jones, D. C., Ariza, A., Chow, W. H., Oza, S. L. and Fairlamb, A. H. (2010) Comparative structural, kinetic and inhibitor studies of Trypanosoma brucei trypanothione reductase with T. cruzi. Mol Biochem Parasitol. 169, 12-19
doi; 10.1016/j.molbiopara.2009.09.002
PMID;2789240  PMC19747949

Jones, D. C., Hallyburton, I., Stojanovski, L., Read, K. D., Frearson, J. A. and Fairlamb, A. H. (2010) Identification of a kappa-opioid agonist as a potent and selective lead for drug development against human African trypanosomiasis. Biochem Pharmacol. 80, 1478-1486
doi; 10.1016/j.bcp.2010.07.038
PMID;3025325  PMC20696141

Kalinichev, M., Bradford, A., Bison, S., Lucas, A., Sartori, I., Garbati, N., Andreetta, F., Bate, S., Austin, N. E., Jones, D. N., Read, K. D., Alvaro, G. and Large, C. H. (2010) Potentiation of the anticonvulsant efficacy of sodium channel inhibitors by an NK1-receptor antagonist in the rat. Epilepsia. 51, 1543-1551
doi; 10.1111/j.1528-1167.2009.02482.x

Kalinowska-Tluscik, J., Miallau, L., Gabrielsen, M., Leonard, G. A., McSweeney, S. M. and Hunter, W. N. (2010) A triclinic crystal form of Escherichia coli 4-diphosphocytidyl-2C-methyl-D-erythritol kinase and reassessment of the quaternary structure. Acta crystallographica. Section F, Structural biology and crystallization communications. 66, 237-241
doi; 10.1107/S1744309109054591
PMID;2833027  PMC20208151

Klee, N., Wong, P. E., Baragana, B., Mazouni, F. E., Phillips, M. A., Barrett, M. P. and Gilbert, I. H. (2010) Selective delivery of 2-hydroxy APA to Trypanosoma brucei using the melamine motif. Bioorg Med Chem Lett. 20, 4364-4366
doi; 10.1016/j.bmcl.2010.06.070
PMID;2935964  PMC20615694

Ma, J., Benz, C., Grimaldi, R., Stockdale, C., Wyatt, P., Frearson, J. and Hammarton, T. C. (2010) Nuclear DBF-2-related kinases are essential regulators of cytokinesis in bloodstream stage Trypanosoma brucei. J Biol Chem. 285, 15356-15368
doi; 10.1074/jbc.M109.074591
PMID;2865264  PMC20231285

Marino, K., Guther, M. L., Wernimont, A. K., Amani, M., Hui, R. and Ferguson, M. A. (2010) Identification, subcellular localization, biochemical properties, and high-resolution crystal structure of Trypanosoma brucei UDP-glucose pyrophosphorylase. Glycobiology. 20, 1619-1630
doi; 10.1093/glycob/cwq115
PMID;3270307  PMC20724435

Martin, D. M., Nett, I. R., Vandermoere, F., Barber, J. D., Morrice, N. A. and Ferguson, M. A. (2010) Prophossi: automating expert validation of phosphopeptide-spectrum matches from tandem mass spectrometry. Bioinformatics. 26, 2153-2159
doi; 10.1093/bioinformatics/btq341
PMID;2922888  PMC20651112

Mehlert, A., Sullivan, L. and Ferguson, M. A. (2010) Glycotyping of Trypanosoma brucei variant surface glycoprotein MITat1.8. Mol Biochem Parasitol. 174, 74-77
doi; 10.1016/j.molbiopara.2010.06.007
PMID;2935967  PMC20558211

Micheli, F., Cavanni, P., Andreotti, D., Arban, R., Benedetti, R., Bertani, B., Bettati, M., Bettelini, L., Bonanomi, G., Braggio, S., Carletti, R., Checchia, A., Corsi, M., Fazzolari, E., Fontana, S., Marchioro, C., Merlo-Pich, E., Negri, M., Oliosi, B., Ratti, E., Read, K. D., Roscic, M., Sartori, I., Spada, S., Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A., Zonzini, L. and Di Fabio, R. (2010) 6-(3,4-dichlorophenyl)-1-[(methyloxy)methyl]-3-azabicyclo[4.1.0]heptane: a new potent and selective triple reuptake inhibitor. J Med Chem. 53, 4989-5001
doi; 10.1021/jm100481d

Micheli, F., Cavanni, P., Arban, R., Benedetti, R., Bertani, B., Bettati, M., Bettelini, L., Bonanomi, G., Braggio, S., Checchia, A., Davalli, S., Di Fabio, R., Fazzolari, E., Fontana, S., Marchioro, C., Minick, D., Negri, M., Oliosi, B., Read, K. D., Sartori, I., Tedesco, G., Tarsi, L., Terreni, S., Visentini, F., Zocchi, A. and Zonzini, L. (2010) 1-(Aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes and 6-(aryl)-6-[alkoxyalkyl]-3-azabicyclo[3.1.0]hexanes: a new series of potent and selective triple reuptake inhibitors. J Med Chem. 53, 2534-2551
doi; 10.1021/jm901818u

Nett, I. R., Mehlert, A., Lamont, D. and Ferguson, M. A. (2010) Application of electrospray mass spectrometry to the structural determination of glycosylphosphatidylinositol membrane anchors. Glycobiology. 20, 576-585
doi; 10.1093/glycob/cwq007
PMID;2850939  PMC20100693

Nicoletti, S., Seifert, K. and Gilbert, I. H. (2010) Water-soluble polymer-drug conjugates for combination chemotherapy against visceral leishmaniasis. Bioorg Med Chem. 18, 2559-2565
doi; 10.1016/j.bmc.2010.02.043
PMID;2862900  PMC20338769

Oke, M., Carter, L. G., Johnson, K. A., Liu, H., McMahon, S. A., Yan, X., Kerou, M., Weikart, N. D., Kadi, N., Sheikh, M. A., Schmelz, S., Dorward, M., Zawadzki, M., Cozens, C., Falconer, H., Powers, H., Overton, I. M., van Niekerk, C. A., Peng, X., Patel, P., Garrett, R. A., Prangishvili, D., Botting, C. H., Coote, P. J., Dryden, D. T., Barton, G. J., Schwarz-Linek, U., Challis, G. L., Taylor, G. L., White, M. F. and Naismith, J. H. (2010) The Scottish Structural Proteomics Facility: targets, methods and outputs. J Struct Funct Genomics. 11, 167-180
doi; 10.1007/s10969-010-9090-y
PMID;2883930  PMC20419351

Ono, M., Yamada, K., Avolio, F., Scott, M. S., van Koningsbruggen, S., Barton, G. J. and Lamond, A. I. (2010) Analysis of human small nucleolar RNAs (snoRNA) and the development of snoRNA modulator of gene expression vectors. Mol Biol Cell. 21, 1569-1584
doi; 10.1091/mbc.E10-01-0078
PMID;2861615  PMC20219969

Patterson, S. M., Hughes, C. M., Crealey, G., Cardwell, C. and Lapane, K. L. (2010) An evaluation of an adapted U.S. model of pharmaceutical care to improve psychoactive prescribing for nursing home residents in northern ireland (fleetwood northern ireland study). J Am Geriatr Soc. 58, 44-53
doi; 10.1111/j.1532-5415.2009.02617.x

Price, H. P., Guther, M. L., Ferguson, M. A. and Smith, D. F. (2010) Myristoyl-CoA:protein N-myristoyltransferase depletion in trypanosomes causes avirulence and endocytic defects. Mol Biochem Parasitol. 169, 55-58
doi; 10.1016/j.molbiopara.2009.09.006
PMID;2789243  PMC19782106

Procter, J. B., Thompson, J., Letunic, I., Creevey, C., Jossinet, F. and Barton, G. J. (2010) Visualization of multiple alignments, phylogenies and gene family evolution. Nat Methods. 7, S16-25
doi; 10.1038/nmeth.1434

Read, K. D. and Braggio, S. (2010) Assessing brain free fraction in early drug discovery. Expert Opin Drug Metab Toxicol. 6, 337-344
doi; 10.1517/17425250903559873

Remenyi, J., Hunter, C. J., Cole, C., Ando, H., Impey, S., Monk, C. E., Martin, K. J., Barton, G. J., Hutvagner, G. and Arthur, J. S. (2010) Regulation of the miR-212/132 locus by MSK1 and CREB in response to neurotrophins. Biochem J. 428, 281-291
doi; 10.1042/BJ20100024

Rimland, J., Dunne, A., Hunjan, S. S., Sasse, R., Uings, I., Montanari, D., Caivano, M., Shah, P., Standing, D., Gray, D., Brown, D., Cairns, W., Trump, R., Smith, P. W., Bertheleme, N., D'Alessandro, P., Gul, S., Vimal, M., Smith, D. N. and Watson, S. P. (2010) The identification a novel, selective, non-steroidal, functional glucocorticoid receptor antagonist. Bioorg Med Chem Lett. 20, 2340-2343
doi; 10.1016/j.bmcl.2010.01.133

Robinson, M. A., Barton, G. J., Lees, A. and Sett, P. (2010) Analysis of tetraplegic reaching in their 3D workspace following posterior deltoid-triceps tendon transfer. Spinal Cord. 48, 619-627
doi; 10.1038/sc.2009.193

Ruda, G. F., Campbell, G., Alibu, V. P., Barrett, M. P., Brenk, R. and Gilbert, I. H. (2010) Virtual fragment screening for novel inhibitors of 6-phosphogluconate dehydrogenase. Bioorg Med Chem. 18, 5056-5062
doi; 10.1016/j.bmc.2010.05.077
PMID;2939770  PMC20598892

Ruda, G. F., Wong, P. E., Alibu, V. P., Norval, S., Read, K. D., Barrett, M. P. and Gilbert, I. H. (2010) Aryl phosphoramidates of 5-phospho erythronohydroxamic acid, a new class of potent trypanocidal compounds. J Med Chem. 53, 6071-6078
doi; 10.1021/jm1004754
PMID;2923871  PMC20666371

Rush, C. L., Schuttelkopf, A. W., Hurtado-Guerrero, R., Blair, D. E., Ibrahim, A. F., Desvergnes, S., Eggleston, I. M. and van Aalten, D. M. (2010) Natural product-guided discovery of a fungal chitinase inhibitor. Chem Biol. 17, 1275-1281
doi; 10.1016/j.chembiol.2010.07.018
PMID;3518266  PMC21168763

Schimpl, M., Schuttelkopf, A. W., Borodkin, V. S. and van Aalten, D. M. (2010) Human OGA binds substrates in a conserved peptide recognition groove. Biochem J. 432, 1-7
doi; 10.1042/BJ20101338
PMID;2973230  PMC20863279

Schuttelkopf, A. W., Gros, L., Blair, D. E., Frearson, J. A., van Aalten, D. M. and Gilbert, I. H. (2010) Acetazolamide-based fungal chitinase inhibitors. Bioorg Med Chem. 18, 8334-8340
doi; 10.1016/j.bmc.2010.09.062
PMID;2997425  PMC21044846

Scott, M. S., Boisvert, F. M., McDowall, M. D., Lamond, A. I. and Barton, G. J. (2010) Characterization and prediction of protein nucleolar localization sequences. Nucleic Acids Res. 38, 7388-7399
doi; 10.1093/nar/gkq653
PMID;2995072  PMC20663773

Shanks, E. J., Ong, H. B., Robinson, D. A., Thompson, S., Sienkiewicz, N., Fairlamb, A. H. and Frearson, J. A. (2010) Development and validation of a cytochrome c-coupled assay for pteridine reductase 1 and dihydrofolate reductase. Anal Biochem. 396, 194-203
doi; 10.1016/j.ab.2009.09.003
PMID;2789237  PMC19748480

Sienkiewicz, N., Ong, H. B. and Fairlamb, A. H. (2010) Trypanosoma brucei pteridine reductase 1 is essential for survival in vitro and for virulence in mice. Molecular microbiology. 77, 658-671
doi; 10.1111/j.1365-2958.2010.07236.x
PMID;2916222  PMC20545846

Sledz, P., Silvestre, H. L., Hung, A. W., Ciulli, A., Blundell, T. L. and Abell, C. (2010) Optimization of the interligand Overhauser effect for fragment linking: application to inhibitor discovery against Mycobacterium tuberculosis pantothenate synthetase. J Am Chem Soc. 132, 4544-4545
doi; 10.1021/ja100595u

Sokolova, A. Y., Wyllie, S., Patterson, S., Oza, S. L., Read, K. D. and Fairlamb, A. H. (2010) Cross-resistance to nitro drugs and implications for treatment of human African trypanosomiasis. Antimicrob Agents Chemother. 54, 2893-2900
doi; 10.1128/AAC.00332-10
PMID;2897277  PMC20439607

Tulloch, L. B., Martini, V. P., Iulek, J., Huggan, J. K., Lee, J. H., Gibson, C. L., Smith, T. K., Suckling, C. J. and Hunter, W. N. (2010) Structure-based design of pteridine reductase inhibitors targeting African sleeping sickness and the leishmaniases. J Med Chem. 53, 221-229
doi; 10.1021/jm901059x
PMID;2804273  PMC19916554

van Koningsbruggen, S., Gierlinski, M., Schofield, P., Martin, D., Barton, G. J., Ariyurek, Y., den Dunnen, J. T. and Lamond, A. I. (2010) High-resolution whole-genome sequencing reveals that specific chromatin domains from most human chromosomes associate with nucleoli. Mol Biol Cell. 21, 3735-3748
doi; 10.1091/mbc.E10-06-0508
PMID;2965689  PMC20826608

Wang, Y. N., Wang, M. and Field, M. C. (2010) Trypanosoma brucei: trypanosome-specific endoplasmic reticulum proteins involved in variant surface glycoprotein expression. Exp Parasitol. 125, 208-221
doi; 10.1016/j.exppara.2010.01.015
PMID;2877885  PMC20109450

Whittingham, J. L., Carrero-Lerida, J., Brannigan, J. A., Ruiz-Perez, L. M., Silva, A. P., Fogg, M. J., Wilkinson, A. J., Gilbert, I. H., Wilson, K. S. and Gonzalez-Pacanowska, D. (2010) Structural basis for the efficient phosphorylation of AZT-MP (3'-azido-3'-deoxythymidine monophosphate) and dGMP by Plasmodium falciparum type I thymidylate kinase. Biochem J. 428, 499-509
doi; 10.1042/BJ20091880

Wyllie, S., Mandal, G., Singh, N., Sundar, S., Fairlamb, A. H. and Chatterjee, M. (2010) Elevated levels of tryparedoxin peroxidase in antimony unresponsive Leishmania donovani field isolates. Mol Biochem Parasitol. 173, 162-164
doi; 10.1016/j.molbiopara.2010.05.015
PMID;3428625  PMC20553768