University of Dundee

2021

Aguado ME, González-Matos M, Izquierdo M, Quintana J, Field MC, González-Bacerio J. 2021. Expression in Escherichia coli, purification and kinetic characterization of LAPLm, a Leishmania major M17-aminopeptidase. Protein Expression and Purification. 183:Article 105877. https://doi.org/10.1016/j.pep.2021.105877

Arendse LB, Wyllie S, Chibale K, Gilbert IH. 2021. Plasmodium Kinases as Potential Drug Targets for Malaria: Challenges and Opportunities. ACS Infectious Diseases. 7(3):518-534. https://doi.org/10.1021/acsinfecdis.0c00724

Barker S, Harding SV, Gray D, Richards MI, Atkins HS, Harmer NJ. 2021. Drug screening to identify compounds to act as co-therapies for the treatment of Burkholderia species. PLoS ONE. 16(3):Article e0248119. https://doi.org/10.1371/journal.pone.0248119

Brandon AM, Antonides LH, Riley J, Epemolu O, McKeown DA, Read KD, McKenzie C. 2021. A Systematic Study of the In Vitro Pharmacokinetics and Estimated Human In Vivo Clearance of Indole and Indazole-3-Carboxamide Synthetic Cannabinoid Receptor Agonists Detected on the Illicit Drug Market. Molecules. 26(5):Article 1396. https://doi.org/10.3390/molecules26051396

Butenko A, Hammond M, Field MC, Ginger ML, Yurchenko V, Lukeš J. 2021. Reductionist Pathways for Parasitism in Euglenozoans? Expanded Datasets Provide New Insights. Trends in Parasitology. 37(2):100-116. https://doi.org/10.1016/j.pt.2020.10.001

Faria J, Luzak V, Müller LSM, Brink BG, Hutchinson S, Glover L, Horn D, Siegel TN. 2021. Spatial integration of transcription and splicing in a dedicated compartment sustains monogenic antigen expression in African trypanosomes. Nature Microbiology. 6:289-300. https://doi.org/10.1038/s41564-020-00833-4

Farnaby W, Koegl M, McConnell DB, Ciulli A. 2021. Transforming targeted cancer therapy with PROTACs: A forward-looking perspective. Current Opinion in Pharmacology. 57:175-183. https://doi.org/10.1016/j.coph.2021.02.009

Hickerson R, Conneely M, Tsutsumi SKH, Wood K, Jackson D, Ibbotson S, Eadie E. 2021. Minimal, superficial DNA damage in human skin from filtered far-ultraviolet C. British Journal of Dermatology. https://doi.org/10.1111/bjd.19816

Ji Z, Tinti M, Ferguson MAJ. 2021. Proteomic identification of the UDP-GlcNAc: PI α1-6 GlcNAc-transferase subunits of the glycosylphosphatidylinositol biosynthetic pathway of Trypanosoma brucei. PLoS ONE. 16(3):Article e0244699. https://doi.org/10.1371/journal.pone.0244699

Libardo MDJ, Duncombe CJ, Green SR, Wyatt PG, Thompson S, Ray PC, Ioerger TR, Oh S, Goodwin MB, Boshoff HIM, Barry III CE. 2021. Resistance of Mycobacterium tuberculosis to indole 4-carboxamides occurs through alterations in drug metabolism and tryptophan biosynthesis. Cell Chemical Biology. 28:1–12.e1–e20. https://doi.org/10.1016/j.chembiol.2021.02.023

Makukhin N, Ciulli A. 2021. Recent advances in synthetic and medicinal chemistry of phosphotyrosine and phosphonate-based phosphotyrosine analogues. RSC Medicinal Chemistry. 12(1):8-23. https://doi.org/10.1039/D0MD00272K

Marrs T, Jo JH, Perkin MR, Rivett DW, Witney AA, Bruce KD, Logan K, Craven J, Radulovic S, Versteeg SA, van Ree R, McLean WHI, Strachan DP, Lack G, Kong HH, Flohr C. 2021. Gut microbiota development during infancy: Impact of introducing allergenic foods. Journal of Allergy and Clinical Immunology. 147(2):613-621.e9. https://doi.org/10.1016/j.jaci.2020.09.042

Mendes V, Green SR, Evans JC, Hess J, Blaszczyk M, Spry C, Bryant O, Cory-Wright J, Chan DS-H, Torres PHM, Wang Z, Nahiyaan N, O'Neill S, Damerow S, Post J, Bayliss T, Lynch SL, Coyne AG, Ray PC, Abell C, Rhee KY, Boshoff HIM, Barry CE, Mizrahi V, Wyatt PG, Blundell TL. 2021. Inhibiting Mycobacterium tuberculosis CoaBC by targeting an allosteric site. Nature Communications. 12:Article 143. https://doi.org/10.1038/s41467-020-20224-x

Michalska K, Jedrzejczak R, Wower J, Chang C, Baragaña B, Gilbert IH, Forte B, Joachimiak A. 2021. Mycobacterium tuberculosis Phe-tRNA synthetase: structural insights into tRNA recognition and aminoacylation. Nucleic Acids Research. https://doi.org/10.1093/nar/gkab272

Moitra S, Basu S, Pawlowic M, Hsu FF, Zhang K. 2021. De Novo Synthesis of Phosphatidylcholine Is Essential for the Promastigote But Not Amastigote Stage in Leishmania major. Frontiers in Cellular and Infection Microbiology. 11:Article 647870. https://doi.org/10.3389/fcimb.2021.647870

Oh S, Libardo MDJ, Azeeza S, Pauly GT, Roma JSO, Sajid A, Tateishi Y, Duncombe C, Goodwin M, Ioerger TR, Wyatt PG, Ray PC, Gray DW, Boshoff HIM, Barry CE. 2021. Structure-Activity Relationships of Pyrazolo[1,5-a]pyrimidin-7(4H)-ones as Antitubercular Agents. ACS Infectious Diseases. 7(2):479-492. https://doi.org/10.1021/acsinfecdis.0c00851

Padilla-Mejia NE, Makarov AA, Barlow LD, Butterfield ER, Field MC. 2021. Evolution and diversification of the nuclear envelope. Nucleus. 12(1):21-41. https://doi.org/10.1080/19491034.2021.1874135

Pearson L-A, Green C, Lin D, Petit A-P, Gray D, Cowling V, Fordyce E. 2021. Development of a High-Throughput Screening Assay to Identify Inhibitors of the SARS-CoV-2 Guanine-N7 Methyltransferase Using RapidFire Mass Spectrometry. SLAS Discovery. https://doi.org/10.1177/24725552211000652

Quintana JF, Field MC. 2021. Evolution, function and roles in drug sensitivity of trypanosome aquaglyceroporins. Parasitology. https://doi.org/10.1017/S0031182021000354

Ramachandran S, Ciulli A. 2021. Building ubiquitination machineries: E3 ligase multi-subunit assembly and substrate targeting by PROTACs and molecular glues. Current Opinion in Structural Biology. 67:110-119. https://doi.org/10.1016/j.sbi.2020.10.009

Ray PC, Huggett M, Turner PA, Taylor M, Cleghorn LAT, Early J, Kumar A, Bonnett SA, Flint L, Joerss D, Johnson J, Korkegian A, Mullen S, Moure AL, Davis SH, Murugesan D, Mathieson M, Caldwell N, Engelhart CA, Schnappinger D, Epemolu O, Zuccotto F, Riley J, Scullion P, Stojanovski L, Massoudi L, Robertson GT, Lenaerts AJ, Freiberg G, Kempf DJ, Masquelin T, Hipskind PA, Odingo J, Read KD, Green SR, Wyatt PG, Parish T. 2021. Spirocycle MmpL3 Inhibitors with Improved hERG and Cytotoxicity Profiles as Inhibitors of Mycobacterium tuberculosis Growth. ACS Omega. 6(3):2284-2311. https://doi.org/10.1021/acsomega.0c05589

Rihn SJ, Merits A, Bakshi S, Turnbull ML, Wickenhagen A, Alexander AJT, Baillie C, Brennan B, Brown F, Brunker K, Bryden SR, Burness KA, Carmichael S, Cole SJ, Cowton VM, Davies P, Davis C, De Lorenzo G, Donald CL, Dorward M, Dunlop JI, Elliott M, Fares M, da Silva Filipe A, Freitas JR, Furnon W, Gestuveo RJ, Geyer A, Giesel D, Goldfarb DM, Goodman N, Gunson R, Hastie CJ, Herder V, Hughes J, Johnson C, Johnson N, Kohl A, Kerr K, Leech H, Lello LS, Li K, Lieber G, Liu X, Lingala R, Loney C, Mair D, McElwee MJ, McFarlane S, Nichols J, Nomikou K, Orr A, Orton RJ, Palmarini M, Parr YA, Pinto RM, Raggett S, Reid E, Robertson DL, Royle J, Cameron-Ruiz N, Shepherd JG, Smollett K, Stewart DG, Stewart M, Sugrue E, Szemiel AM, Taggart A, Thomson EC, Tong L, Torrie LS, Toth R, Varjak M, Wang S, Wilkinson SG, Wyatt PG, Zusinaite E, Alessi DR, Patel AH, Zaid A, Wilson SJ, Mahalingam S. 2021. A plasmid DNA-launched SARS-CoV-2 reverse genetics system and coronavirus toolkit for COVID-19 research. PLoS Biology. 19(2):Article e3001091. https://doi.org/10.1371/journal.pbio.3001091

Sampaio Guther ML, Prescott AR, Kuettel S, Tinti M, Ferguson MAJ. 2021. Nucleotide sugar biosynthesis occurs in the glycosomes of procyclic and bloodstream form Trypanosoma brucei. PLoS Neglected Tropical Diseases. 15(2):Article e0009132. https://doi.org/10.1371/journal.pntd.0009132

Soares de Melo C, Singh V, Myrick A, Simelane SB, Taylor D, Brunschwig C, Lawrence N, Schnappinger D, Engelhart CA, Kumar A, Parish T, Su Q, Myers TG, Boshoff HIM, Barry CE, Sirgel FA, van Helden PD, Buchanan KI, Bayliss T, Green SR, Ray PC, Wyatt PG, Basarab GS, Eyermann CJ, Chibale K, Ghorpade SR. 2021. Antitubercular 2-Pyrazolylpyrimidinones: Structure-Activity Relationship and Mode-of-Action Studies. Journal of Medicinal Chemistry. 64(1):719-740. https://doi.org/10.1021/acs.jmedchem.0c01727

S. Paradela L, Wall RJ, Carvalho S, Chemi G, Corpas-Lopez V, Moynihan E, Bello D, Patterson S, S. Guther ML, Fairlamb AH, Ferguson MAJ, Zuccotto F, Martin J, Gilbert IH, Wyllie S. 2021. Multiple unbiased approaches identify oxidosqualene cyclase as the molecular target of a promising anti-leishmanial. Cell Chemical Biology. 28. https://doi.org/10.1016/j.chembiol.2021.02.008

Thomas M, Brand S, De Rycker M, Zuccotto F, Lukac I, Dodd P, Ko E-J, Manthri S, McGonagle K, Osuna-Cabello M, Riley J, Pont C, Simeons F, Stojanovski L, Thomas J, Thompson S, Viayna E, Fiandor JM, Martín J, Wyatt PG, Miles TJ, Read KD, Marco M, Gilbert IH. 2021. A scaffold-hopping strategy on a series of proteasome inhibitors which led to a preclinical candidate for the treatment of visceral leishmaniasis. Journal of Medicinal Chemistry. https://doi.org/10.1021/acs.jmedchem.1c00047

Yang T, Ottilie S, Istvan ES, Godinez-Macias KP, Lukens AK, Baragaña B, Campo B, Walpole C, Niles JC, Chibale K, Dechering KJ, Llinás M, Lee MCS, Kato N, Wyllie S, McNamara CW, Gamo FJ, Burrows J, Fidock DA, Goldberg DE, Gilbert IH, Wirth DF, Winzeler EA, Malaria Drug Accelerator Consortium. 2021. MalDA, Accelerating Malaria Drug Discovery. Trends in Parasitology. https://doi.org/10.1016/j.pt.2021.01.009